| new delhi metallo-beta lactamase (ndm-1) in enterobacteriaceae: treatment options with carbapenems compromised. | carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase. however resistance to carbapenems occurs and is mediated by mechanisms like loss of outer membrane proteins and production of beta lactamase that is capable of hydrolyzing carbapenems. an alert issued in the uk in 2009 warned of an increasing number of carbapenem resistant enterobacteriaceae strains identified in uk hospital patients. many ... | 2010 | 20848811 |