Publications

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distribution of p53, gst, and mthfr polymorphisms and risk of cervical intraepithelial lesions in sicily.host factors, including genetic polymorphisms, may explain some of the individual differences in cervical cancer occurrence, and susceptibility information may be useful to address effective and specific preventive strategies for different countries. the purpose of the present study was to investigate the role of p53 codon 72, glutathione s-transferase class mu (gstm1), glutathione s-transferase class theta (gstt1), and methylenetetrahydrofolate reductase (mthfr) c677t polymorphisms on the risk ...201020130515
detection and genotyping of human papillomavirus in gynaecologic outpatients of messina, eastern sicily, italy.in order to determine the prevalence of human papillomavirus (hpv) infection in sexually active female population in messina, we tested cervical scrapes of women referred to university clinics for routine gynaecologic care. between march and december 2008, a total of 680 cervical samples of 598 patients (573 italian from province of messina and 25 resident aliens) were examined consecutively from laboratory of molecular biology at the department of human pathology. for each sample, cervical cell ...201020127015
human papillomavirus infection: low-risk and high-risk genotypes in women in catania, sicily.human papillomavirus (hpv) infection has been strongly and consistently associated with cervical carcinoma and its cytologic precursors, such as squamous intraepithelial lesions. a cross-sectional survey was conducted with the aim of estimating the prevalence of cervical hpv infection in women attending a service of colposcopy in catania, eastern sicily, italy.200919820375
prevalence of cervical human papillomavirus infection and types among women immigrated to sicily, italy.we determined the prevalence of human papillomavirus (hpv) cervical infection and hpv genotypes among 115 women immigrating to sicily (italy), with regard to abnormal cytology and socio-behavioral characteristics in a cross-sectional, observational study. information was collected with the help of cultural mediators/translators. hpv-dna was assayed by the innolipa hpv assay and a nested pcr/sequencing method. sixty (52.2%) women came from sub-saharan africa and 55 (47.8%) from eastern europe. hp ...200919412805
human papillomavirus types distribution in eastern sicilian females with cervical lesions. a correlation with colposcopic and histological findings.to determine human papillomavirus (hpv) types distribution in cervical lesions in a southern italian female population in messina and their relationship between hpv type and grade of colposcopic and histopathological abnormality, a total of 253 women aged 17-68 years, with previous cytological abnormalities, were included in this study. hpv-dna testing, colposcopy and biopsy were performed. for each sample, cervical cells were collected by centrifugation and dna was extracted, followed by a pcr- ...201323420303
facilitators and barriers hpv unvaccinated girls after 5 years of program implementation.understanding perceptions and characteristics of human papillomavirus (hpv) vaccinated and non-vaccinated girls can inform communication activities and vaccine delivery strategies. the purpose of this study was to evaluate knowledge and factors associated with hpv unvaccinated girls after five years of vaccination program implementation in sicily, an italian region with low vaccination coverage (<50.0%). a cross-sectional study was conducted through a questionnaire designed to assess knowledge a ...201525483543
comparison of clinical performance of abbott realtime high risk hpv test with that of hybrid capture 2 assay in a screening setting.randomized trials have produced sound evidence about the efficacy of screening with human papillomavirus (hpv) dna tests in reducing cervical cancer incidence and mortality. we evaluated the clinical performance and reproducibility of the abbott realtime high risk (hr) hpv test compared with that of the hr hybrid capture 2 (hc2) assay as assessed by a noninferiority score test. a random sample of 998 cervical specimens (914 specimens of cervical intraepithelial neoplasia less severe than grade 2 ...201121325553
prevalence of genital human papilloma virus infection and genotypes among young women in sicily, south italy.infection with oncogenic human papilloma virus (hpv) types is a necessary cause of cervical cancer. this study assessed the prevalence of hpv infection and genotypes among 1,006 randomly selected women, ages 18 to 24 years, living in sicily (south italy). the overall hpv rate was 24.1% (95% confidence interval, 21.5-26.9). the most frequent types were hpv-16 (4.5%), hpv-53 (2.7%), and hpv-84 (2.6%). the prevalence of vaccine types hpv-6, hpv-11, and hpv-18 was 1.4%, 0.1%, and 1.3%, respectively. ...200818708390
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