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a field study of household attack rates and the effectiveness of macrolide antibiotics in reducing household transmission of pertussis.bordetella pertussis (whooping cough) is an endemic, highly contagious bacterial respiratory infection, which is notifiable to australian state and territory health departments. between 2008 and 2011 there was a substantial outbreak in new south wales with an initial increase in cases occurring in north coast new south wales from late 2007. during september and october 2011 the north coast public health unit conducted a household study of secondary attack rates to assess the effectiveness of per ...201526063095
shift in the epidemiology of pertussis infection: an indication for pertussis vaccine boosters for adults?pertussis vaccination of young children has been effective in reducing the overall disease burden due to bordetella pertussis in many countries. however, the disease has not been eliminated, although humans are the only known host of this pathogen. in fact, in some countries, the number of reported cases has increased dramatically from their nadir and epidemics routinely occur. in areas where >80% of children <2 years of age have been vaccinated, the burden of disease has shifted from elementary ...200616706548
national study of infants hospitalized with pertussis in the acellular vaccine era.in australia in 1999 acellular pertussis vaccine (dtpa) replaced locally manufactured whole cell vaccine given at 2, 4 and 6 months of age with coverage of about 95% by 12 months of age. few data are available on pertussis hospitalizations or sources of infection in countries exclusively using dtpa.200415014301
A Prospective Evaluation of an Australian Pertussis Toxin IgG and IgA Enzyme Immunoassay.Background:Serological diagnosis of recent pertussis infection is an important part of both clinical assessment and epidemiological documentation of this disease. Standardisation of serological testing and interpretation remains challenging despite international efforts to improve this. Currently, IgG-anti-Pertussis Toxin (PT) is recommended as the most accurate serological test in Europe and USA, while Australia predominantly relies on measurement of IgA Bordetella pertussis antibody responses. ...201122131356
bordetella pertussis pcr positivity, following onset of illness in children under 5 years of age.bordetella pertussis is a significant cause of respiratory illness and an ongoing public health problem. pertussis polymerase chain reaction (pcr) testing has been widely utilised since 2001, especially in infants. uncertainty exists as to how long pcr remains positive following symptom onset. further information on the time frame for pertussis pcr testing would assist diagnosis, epidemiological research and disease control. the brisbane southside population health unit (bsphu) conducted a retro ...200717724996
pertussis epidemiology in australia over the decade 1995-2005--trends by region and age group.important changes have occurred in the national immunisation program for pertussis during the decade 1995-2005, including the introduction of acellular pertussis vaccine for all doses, removal from the schedule of the booster dose at 18 months, and the introduction of a booster dose for adolescents. in addition, the coverage of pertussis vaccine at 12 and 24 months has substantially increased as recorded by australian bureau of statistics surveys and the australian childhood immunisation registe ...200717724997
survey of pertussis morbidity in adults in western sydney.to estimate morbidity due to bordetella pertussis infection in a representative population of australian adults.200010937031
The impact of adolescent pertussis immunization, 2004-2009: lessons from Australia.To compare the impact of three strategies for delivering a booster dose of adult-formulated tetanus-diphtheria-pertussis (Tdap) vaccine to adolescents in Australia. These comprise: (i) administering Tdap to: a one-year age cohort; (ii) administering Tdap to the entire high school and to subsequent entrant cohorts; and (iii) administering Tdap to the entire high school but without continuing to immunize entrant cohorts.201121897487
the outbreak that had to happen: bordetella pertussis in north-west western australia in 1999.in late 1999, an outbreak of bordetella pertussis occurred in a small town in north-west western australia. we undertook an investigation to describe the outbreak and to identify strategies to minimise the impact of future pertussis outbreaks in australia. in november, people with respiratory symptoms were reviewed in an emergency pertussis clinic, which provided antibiotic treatment or prophylaxis. we conducted a school survey to enhance case ascertainment and followed up those attending the cl ...200011225380
the re-emergence of pertussis: implications for diagnosis and surveillance.pertussis, or whooping cough, a highly contagious disease caused by bordetella pertussis, is making a comeback globally and nationally in spite of reasonable vaccination coverage. this paper provides an update on laboratory testing methods that assist the confirmation of clinical disease and investigation of outbreaks. laboratory confirmation of the diagnosis by polymerase chain reaction or serology should be attempted, especially when atypical pertussis is suspected clinically. genetic and anti ...200819007547
immunogenicity of specific bordetella pertussis surface antigens in diphtheria-tetanus-pertussis (dtp) vaccines.the predominant causative organism of whooping cough in australia is of a serotype which has normally been associated overseas with unvaccinated communities. australian dtp vaccines pass the statutory mouse test for bordetella pertussis potency but this test is now believed to be relatively insensitive to certain factors, especially the major type-specific agglutinogens, which are presumably also important in the human host-parasite relationship. because endemic b. bronchiseptica infections make ...19882897927
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