evaluation of fas2-elisa for the serological detection of fasciola hepatica infection in humans.the performance of fas2-elisa for the diagnosis of fasciola hepatica infection in children living in areas of high endemicity for fascioliasis in the peruvian andes is analyzed. fas2-elisa is based on the detection of circulating igg antibodies elicited in infected individuals against a f. hepatica antigen termed fas2. the study was conducted in three andean localities, huertas-julcan in junin, asillo in puno, and cajamarca, with a total population of 634 children in an age range 1 to 16 years o ...200717488926
molecular characterisation of galba truncatula, lymnaea neotropica and l. schirazensis from cajamarca, peru and their potential role in transmission of human and animal fascioliasis.human and animal fascioliasis is emerging in many world regions, among which andean countries constitute the largest regional hot spot and peru the country presenting more human endemic areas. a survey was undertaken on the lymnaeid snails inhabiting the hyperendemic area of cajamarca, where human prevalences are the highest known among the areas presenting a "valley transmission pattern", to establish which species are present, genetically characterise their populations by comparison with other ...201222894178
a one-health integrated approach to control fascioliasis in the cajamarca valley of peru.fasciola hepatica infection is reported from many latin american countries, with very high prevalence rates in both humans and livestock in the andean countries. due to its environmental characteristics, particularly suitable for liver fluke infection, the cajamarca valley of peru has often been chosen as a model to study the epidemiology of liver fluke infection in the andes. in this paper we describe the profile of a project aimed at a multidisciplinary and integrated approach for the control ...201223032285
resistance of fasciola hepatica against triclabendazole in cattle in cajamarca (peru): a clinical trial and an in vivo efficacy test in sheep.fasciolosis caused by fasciola hepatica, is the most prevalent parasitic disease in dairy cattle from the northern region of cajamarca, peru. the control of this parasite is based on the use of triclabendazole (tcbz), a drug that has been used for more than fifteen years in this area. recent studies, however, have reported a lack of clinical efficacy after treating dairy cattle. this research was aimed to determine the efficacy of tcbz in a clinical trial. eleven dairy cows all positive to f. he ...201323352107
[fasciolasis in cajamarca].this study is descriptive and retrospective. it is based on the review of clinical and surgery records at the hospital regional de cajamarca from april 1996 to march 2001. 101 cases, positive for fasciolasis in feaces, were analyzed, 62% were under 19 years of age; the male/female ratio was 1:2. the most frequent symptom was abdominal pain (84,5%). the duration of the disease was of less than three months (43,5%). 48% of the patients had eosinophilia. after rewiewing 162 postcholecystectomy pati ...200211961567
human fascioliasis in cajamarca/peru. i. diagnostic methods and treatment with a prospective study 34 peruvian fascioliasis patients were followed up for three months after treatment with praziquantel. the rapid sedimentation of faeces was demonstrated to be the most appropriate parasitological technique for the diagnosis of fasciola hepatica infections in man compared to the mif concentration or the examination of duodenal fluid by enterotest. after therapy with different doses of praziquantel only 21% of the patients stopped to excrete worm eggs although 17 patients h ...19854023557
[knowledge, attitudes and practices about fascioliasis among mothers from an andean rural area of north peru].a survey to determine knowledge, attitudes and practices about fascioliasis was administered to 62 mothers from a rural endemic zone of cajamarca's andean region, peru. only 37.0% recognized the alicuya (local name for fasciola hepatica) as the parasite responsible for the disease; 56.5% knows that the disease affects the liver in the humans and 85.5% knows affects also animals; 98.4% have a positive predisposition to attend informative talks about the disease and 75.8% to support their authorit ...201021072451
fluke egg characteristics for the diagnosis of human and animal fascioliasis by fasciola hepatica and f. trematodiases, shape and size of the fluke eggs shed with faeces are crucial diagnostic features because of their typically reduced intraspecific variability. in fascioliasis, the usual diagnosis during the biliary stage of infection is based on the classification of eggs found in stools, duodenal contents or bile. the aim of the present study is to validate the identification of fasciola species based on the shape and size of eggs shed by humans, characterizing their morphometric traits usin ...200919375410
hyperendemic human fascioliasis in andean valleys: an altitudinal transect analysis in children of cajamarca province, peru.a coprological survey including 476 2-18 year old school children from six rural localities between 2627 and 3061m altitude was performed in cajamarca province, peru. prevalences of fascioliasis ranging from 6.7 to 47.7% (mean 24.4%) proved to be the highest so far recorded in that human hyperendemic area. higher prevalences in females and in the 2-5 year old group were not significant. intensities ranged from 24 to 864 eggs per gram (arithmetic mean: 113; geometric mean: 68), the majority shedd ...201121767521
strategic control of fasciolosis in the inter-andean valley of cajamarca, peru.fasciolosis is recognised as a major problem in dairy cattle in cajamarca, peru. the infection has an annual cycle, with the major period of infection from january to march. a control programme, involving two doses of the fasciolicide triclabendazole aimed at reducing the passage of fasciola hepatica eggs on to the pasture, together with the use of the molluscicide, niclosamide, was evaluated against traditional treatment programmes. the double treatment regimen did not significantly reduce the ...19989699251
[evaluation of an elisa test with fasciola hepatica metabolic antigen for diagnosis of human fascioliasis in cajamarca, peru].metabolic (excretion/secretion) antigen was obtained from sheep infected with fasciola hepatica, with a 1005 μg/μl of protein concentration, composed principally by proteins of molecular weight between 1.2 and 170 kda. bands of 170, 150, 31, 24, 18-14 and 10 kda were detected. with this antigen an elisa test was developed and the cut off was determined in 0.140. we evaluated 33 serums of patient with fascioliasis confirmed by visualization of eggs in feces, 177 serums of persons without fascioli ...201021308197
fasciola hepatica phenotypic characterization in andean human endemic areas: valley versus altiplanic patterns analysed in liver flukes from sheep from cajamarca and mantaro, peru.fascioliasis is a zoonotic parasitic disease caused by fasciola hepatica and fasciola gigantica. of both species, f. hepatica is the only one described in the americas, mainly transmitted by lymnaeid snail vectors of the galba/fossaria group. human fascioliasis endemic areas are mainly located in high altitude areas of andean countries. given the necessity to characterize f. hepatica populations involved, the phenotypic features of fasciolid adults infecting sheep present in human fascioliasis e ...201222285769
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