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the overdiagnosis of lyme disease in children residing in an endemic area.the medical records of 227 children ages 1 to 19 years referred to the lyme disease pediatric clinic over a 32-month period since may 1990 were reviewed. clinico-serologic criteria for a positive diagnosis were applied. one hundred thirty-eight of 227 referred children did not fulfill those criteria and became the study population. four subsets of patients emerged: (1) 54 patients with predominantly subjective symptoms; (2) 52 patients with objective evidence for an alternative diagnosis; (3) ei ...19947859425
serological responses in lyme disease: the influence of sex, age, and environment.in the laboratory, the serodiagnosis of lyme disease is a difficult decision, especially in early disease. the variability in the immune response to the borrelia burgdorferi spirochete and the lack of specificity and sensitivity of commercial assays for the detection of antibodies in early disease have contributed to the difficulty of serodiagnosis. this study examines the serological data of over 20,000 serum specimens submitted for enzyme linked immunosorbent assay (elisa) and/or western blot ...19938323257
borrelia burgdorferi and the causative agent of human granulocytic ehrlichiosis in deer ticks, delaware.during the 1998 hunting season in delaware, 1,480 ticks were collected from 252 white- tailed deer; 98% were ixodes scapularis, a significant increase from the 85% reported in 1988. ticks were tested for borrelia burgdorferi and the causative agent of human granulocytic ehrlichiosis. infection rates remained stable in new castle and kent counties, but increased from <1% to 8% in sussex county.200010905979
lyme disease--united states, 2003-2005.lyme disease is caused by the spirochete borrelia burgdorferi and is transmitted to humans by the bite of infected blacklegged ticks (ixodes spp.). early manifestations of infection include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. left untreated, late manifestations involving the joints, heart, and nervous system can occur. a healthy people 2010 objective (14-8) is to reduce the annual incidence of lyme disease to 9.7 new cases per 100,000 population in 1 ...200717568368
effect of electronic laboratory reporting on the burden of lyme disease surveillance--new jersey, 2001-2006.lyme disease (ld) is a vector-borne illness caused by the spirochete borrelia burgdorferi and transmitted in the united states by blacklegged ticks (ixodes spp.). ld is most commonly found in the northeastern, mid-atlantic, and north-central regions of the united states. in 2005, new jersey reported 38.6 ld cases per 100,000 population, the third-highest incidence in the united states after delaware and connecticut. since 1980, new jersey has mandated that health-care providers and clinical labo ...200818199968
surveillance for lyme disease--united states, 1992-2006.lyme disease is a multisystem disease that occurs in north america, europe, and asia. in the united states, the etiologic agent is borrelia burgdorferi sensu stricto, a spirochete transmitted to humans by infected ixodes scapularis and i. pacificus ticks. the majority of patients with lyme disease develop a characteristic rash, erythema migrans (em), accompanied by symptoms of fever, malaise, fatigue, headache, myalgia, or arthralgia. other manifestations of infection can include arthritis, card ...200818830214
lyme disease: a new tick-transmitted illness now recognized in delaware. 19807202773
the epidemiology of lyme disease in delaware 1989-1992.the study was conducted to describe the temporal, geographic, demographic and treatment characteristics of lyme disease in delaware and to assist health planners in developing and implementing control strategies.19948001695
serologic survey for borrelia burgdorferi antibody in horses referred to a mid-atlantic veterinary teaching hospital.blood samples obtained from 13 of 100 (13%) and 6 of 91 (7%) horses at the george d. widener hospital for large animals in the months of june and october, respectively, had antibody to borrelia burgdorferi as determined by elisa. horses from the states of new york, maryland, delaware, new jersey, and pennsylvania were seropositive for b burgdorferi. the frequency of antibody response in horses from new jersey was greater (p less than 0.05) than the frequency of antibody response in horses from p ...19902332371
three sudden cardiac deaths associated with lyme carditis - united states, november 2012-july 2013.lyme disease is a multisystem illness caused by borrelia burgdorferi, a spirochete transmitted by certain species of ixodes ticks. approximately 30,000 confirmed and probable cases of lyme disease were reported in the united states in 2012, primarily from high-incidence states in the northeast (connecticut, delaware, maine, maryland, massachusetts, new hampshire, new jersey, new york, pennsylvania, rhode island, and vermont) and upper midwest (minnesota and wisconsin). common manifestations incl ...201324336130
lyme disease trends: delaware, 2000 - 2004.lyme disease is the most common vector-borne disease in the united states, with 19,804 cases reported in 2004. during 1992-1998, delaware was among the top 10 states with the highest incidence rates in the united states. we analyzed delaware lyme disease surveillance data for the reporting period of 2000-2004 to characterize trends, identify populations at high risk, examine the frequency of the major clinical features of disease, and report antibiotic usage patterns among reporting clinicians.200717393940
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