Publications

bacterial meningitis--a four year survey in a paediatrics unit.	the aim of this prospective survey was to study the clinical profile, the incidence among the various age groups, the bacteriology, sequelae and mortality in patients, with bacterial meningitis. patients included in the study were 36 cases of bacterial meningitis admitted to the paediatric unit, tan tock seng hospital, singapore, between the period january 1984 to december 1987. of the total number of patients, 36% were in the neonatal age group. positive bacterial cultures were obtained in 45% ...	1989	2696418
necrotising fasciitis: an entity revisited.	necrotising fasciitis is a disease that still carries a high morbidity and mortality despite our better understanding and advances in treatment since 1924 when meleney first studied it. in our department of orthopaedics, this condition appears to be on the increase, and we therefore felt this entity deserved a restudy. since 1985, 15 cases were seen, of which 10 were encountered in 1989. there were no recorded case prior to 1985. our initial results show that the background and outcome parallel ...	1992	1365518
group b streptococcus: maternal carriage rate and early neonatal septicaemia.	between january 1984 and december 1994, 30 cases of early neonatal group b streptococcus (gbs) septicaemia were managed in the neonatal unit, university hospital, kuala lumpur. two neonates were outborn and 28 were inborn, giving an average annual incidence of neonatal gbs septicaemia of 0.4/1000 livebirths among inborn babies. in a separate survey over a three-month period, gbs genital carriage rate among 196 parturients was found to be 9.7%. of the infants with gbs septicaemia, the mean gestat ...	1997	9395802
group b streptococcal septicaemia/meningitis in neonates in a singapore teaching hospital.	our aims were to establish the incidence and clinical characteristics of early and late onset group b streptococcal (gbs) septicaemia in neonates in our hospital over a period of 1 year. routine screening for maternal gbs was not standard practice in the hospital. gbs was isolated from high vaginal swabs (hvs) obtained antenatally or postnatally for risk factors as determined by the obstetrician or neonatologist in charge. data obtained were analyzed separately and these did not form part of the ...	1998	9890223
group b streptococcal meningitis in adults: recent increase in southeast asia.	meningitis caused by streptococcus agalactiae (group b streptococcus) is rare in adults and usually affects patients with predisposing conditions.	2000	10985511
adult community acquired bacterial meningitis in a singaporean teaching hospital. a seven-year overview (1993-2000).	the objective of this study is to describe the bacteriological, clinical and laboratory features of community acquired bacterial meningitis in adults admitted to a singapore tertiary-care hospital.	2002	12693768
epidemiology of beta-haemolytic group g streptococcal bacteraemia in singapore (1996 to 1998).	group g streptococcus (ggs) accounted for 8% to 44% of all bacteraemias due to beta-haemolytic streptococci according to various reports. the aims of this study were 1) to describe the epidemiology of ggs bacteraemia in singapore for which local data are lacking and 2) to compare its frequency of isolation to the other lancefield groups.	2002	11885504
group b streptococcus necrotizing fasciitis: an emerging disease?		2004	15205992
group b streptococcus serotype iii sequence type 283 bacteremia associated with consumption of raw fish, singapore.	we conducted a retrospective study of 40 case-patients and 58 controls as part of a nationwide investigation of a group b streptococcus outbreak in singapore in 2015. eating a chinese-style raw fish dish (yusheng) was a major risk factor for bacteremia, particularly caused by serotype iii sequence type 283.	2016	27767904
group b streptococcus sequence type 283 disease linked to consumption of raw fish, singapore.	an outbreak of invasive group b streptococcus (gbs) disease occurred in singapore in mid-2015. we conducted a case-control study of 22 adults with invasive gbs infections during june 21-november 21, 2015. consumption of raw fish was strongly associated with invasive sequence type 283 infections, but not with non-sequence type 283 infections.	2016	27767905
diffusion-weighted mri abnormalities in an outbreak of streptococcus agalactiae serotype iii, multilocus sequence type 283 meningitis.	in 2015, an outbreak of group b streptococcal (gbs) infection caused by streptococcus agalactiae serotype iii, multilocus sequence type 283, related to consuming infected raw freshwater fish, affected more than 200 patients in singapore. we describe the clinical, laboratory, and neuroimaging features of a subgroup of adults with central nervous system (cns) infections caused by gbs.	2017	27469307
2015 epidemic of severe streptococcus agalactiae sequence type 283 infections in singapore associated with the consumption of raw freshwater fish: a detailed analysis of clinical, epidemiological, and bacterial sequencing data.	streptococcus agalactiae (group b streptococcus [gbs]) has not been described as a foodborne pathogen. however, in 2015, a large outbreak of severe invasive sequence type (st) 283 gbs infections in adults epidemiologically linked to the consumption of raw freshwater fish occurred in singapore. we attempted to determine the scale of the outbreak, define the clinical spectrum of disease, and link the outbreak to contaminated fish.	2017	28475781