placebo-controlled clinical trial of sodium stibogluconate (pentostam) versus ketoconazole for treating cutaneous leishmaniasis in determine the relative efficacy and toxicity of stibogluconate and ketoconazole for the treatment of cutaneous leishmaniasis, a comparative trial was conducted in which 120 guatemalan men with parasitologically proven cutaneous leishmaniasis were randomly divided into three treatment groups: sodium stibogluconate (20 mg of antimony per kilogram per day intravenously for 20 days), ketoconazole (600 mg per day orally for 28 days), and placebo. treatment outcome was influenced by species. among ...19921311351
the natural history of cutaneous leishmaniasis in guatemala.the natural history of american cutaneous leishmaniasis was studied in guatemala by analyzing the characteristics of 355 untreated leishmanial lesions, observing the evolution of 57 lesions on persons who received a placebo in treatment trials, and analyzing data from a population-based survey concerning the duration of 82 untreated lesions. of 25 lesions caused by leishmania mexicana that were followed prospectively, 22 (88%) completely reepithelialized by a median lesion age of 14 weeks, and 1 ...19921538157
isolation of leishmania braziliensis from lutzomyia ovallesi (diptera:psychodidae) in guatemala.leishmania braziliensis is endemic in guatemala and belize in central america. to help identify the vector(s) of this parasite in guatemala, phlebotomine sand flies that were aspirated from the clothing of collectors at tikal national park in the department of the peten were examined for flagellates. lutzomyia ovallesi was found infected with flagellates that were identified as l. braziliensis by isoenzyme electrophoresis. the isoenzyme profile of this isolate matched those from humans from the ...19921575293
vectors of leishmania braziliensis in the petén, guatemala.during a 1-year study, 13 species of sand fly were collected in bite-landing collections on human attractants in tikal, guatemala. using isoenzyme analysis, leishmania braziliensis was identified among isolates from lutzomyia ovallesi, lu. panamensis, and lu. ylephiletor. lutzomyia ovallesi, lu. shannoni, and lu. cruciata were found with flagellates whose isoenzyme patterns matched unidentified flagellates isolated from a patient with mucosal lesions.19911841251
placebo-controlled clinical trial of meglumine antimonate (glucantime) vs. localized controlled heat in the treatment of cutaneous leishmaniasis in guatemala.sixty-six guatemalans with parasitologically proven cutaneous leishmaniasis were randomly and equally divided into 3 treatment groups: those receiving meglumine antimonate (glucantime), 850 mg antimony/day im for 15 days; those receiving localized controlled heat from a radio-frequency generator, 50 degrees c for 30 sec, 3 treatments at 7 day intervals; and those receiving treatment with a placebo. of 53 isolates identified, 40 were leishmania braziliensis braziliensis and 13 were l. mexicana me ...19902405727
cutaneous leishmaniasis from guatemala or yucatan due to leishmania braziliensis braziliensis. 19883235257
cutaneous leishmaniasis in guatemala: isoenzyme characterization of isolates from humans.leishmania organisms cultivated from cutaneous lesions of humans in guatemala were characterized by cellulose acetate electrophoresis. six isolates had electrophoretic enzyme patterns identical to world health organization reference strains of leishmania braziliensis braziliensis, and 5 had patterns identical to reference strains of leishmania mexicana mexicana.19883341522
efficacy of a short course (10 days) of high-dose meglumine antimonate with or without interferon-gamma in treating cutaneous leishmaniasis in guatemala.sixty-six guatemalan men with parasitologically confirmed cutaneous leishmaniasis, due most commonly to leishmania braziliensis, were randomly assigned to receive one of three treatment regimens: meglumine antimonate (meglumine) for 20 days; meglumine for 10 days; and meglumine for 10 days plus alternate-day injections of interferon-gamma. in each group, meglumine was given intravenously as 20 mg of antimony/(kg of body weight.d). all treatment regimens were associated with similar response rate ...19948011819
treatment of new world cutaneous and mucosal leishmaniases.the most extensive investigations of treatment of new world cutaneous leishmaniasis have been performed against l. panamensis disease in colombia, and the relative value of regimens shown there may be instructive for disease from other areas. in colombia, a 90-95% cure rate was achieved with three different drug regimens: the standard regimen of pentavalent antimony (20 mg/ kg/day for 20 days parenterally) a short course of pentamidine (3 mg/kg every other day for four injections intramuscularly ...19968889330
the domestic dog, a potential reservoir for leishmania in the peten region of the present study, domestic dogs in a leishmania endemic area in the peten region of guatemala were sampled to determine if they are a potential reservoir for leishmania parasites. blood from 100 dogs from six villages was tested with two different antibody-capture assays for leishmania-specific antibodies and a 28% seroprevalence was determined. tissue scrapings from six dogs presenting with chronic lesions characteristic of leishmania infection were sampled and four dogs were positive by a ...200312860062
[american cutaneous leishmaniasis: special features in diagnosis and therapy].three weeks after returning from a trip to guatemala, a 33-year-old man developed two ulcers with indurated edges on his right leg and painful lymph nodes in the right groin. his general condition was not impaired.200314523685
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