Publications

epidemiological studies on cystic echinococcosis in china--a review.	in the four decades from 1951 to 1990, the six provinces or autonomous regions (xinjiang, gansu, qinghai, ningxia, xizang and nei monggol) reported a total of 26,065 surgical cases of hydatid disease, most of which were reported in the recent decade. about one third of the patients was children and adolescents under 15 years old. so far, cystic hydatid infections of local origin have been confirmed in 22 provinces, autonomous regions and municipalities in the whole nation. findings of x-ray exam ...	1995	7546341
an epidemiological survey of cystic echinococcosis among tibetan school pupils in west china.	human cystic echinococcosis (ce) caused by infection with a larval stage of echinococcus granulosus is a serious public health problem in west china. because ce is a zoonosis, dogs and livestock are important hosts in transmission. tibetans, especially teenagers, have a natural relationship with these definitive and intermediate hosts in west china and although some areas of tibet are therefore ce-endemic, few, if any, detailed community studies have been reported. a total of 451 tibetan school ...	2001	11579862
short report: identification of echinococcus species from a yak in the qinghai-tibet plateau region of china.	the species identification of an echinococcal lesion in the liver of a yak in the qinghai-tibet plateau region of china, where both echinococcus granulosus and e. multilocularis are present, was difficult to determine because of the atypical appearance of the lesion. polymerase chain reaction-based mitochondrial genotyping allowed us to discriminate the echinococcus species. nucleotide sequences of the cytochrome c oxidase subunit 1 (cox1) and cytochrome b (cytb) genes amplified from the echinoc ...	2003	14640506
echinococcosis on the tibetan plateau: prevalence and risk factors for cystic and alveolar echinococcosis in tibetan populations in qinghai province, china.	infections by larval stages of tapeworms of the genus echinococcus (echinococcosis or hydatid disease) are zoonotic infections of major public health importance throughout much of the world. humans become infected through accidental ingestion of eggs passed in faeces of canid definitive hosts. tibetan populations of china have some of the highest documented levels of infections by both echinococcus granulosus and e. multilocularis, the causes of cystic and alveolar echinococcosis, respectively. ...	2003	15027608
a canine purgation study and risk factor analysis for echinococcosis in a high endemic region of the tibetan plateau.	the tibetan plateau of western china has been shown to have a very high prevalence of human cystic echinococcosis (ce) caused by echinococcus granulosus and human alveolar echinococcosis (ae) caused by echinococcus multilocularis. the domestic dog is suspected to be the primary definitive host for the transmission of both e. granulosus and e. multilocularis to humans in this locality. a purgation study of 371 dogs in shiqu county, sichuan province during 2002-2003 resulted in an e. multiloculari ...	2005	15619374
echinococcus shiquicus, a new species from the qinghai-tibet plateau region of china: discovery and epidemiological implications.	in shiqu county of the qinghai-tibet plateau, many wild and domestic mammals are involved in the transmission cycles of echinococcus spp. echinococcus multilocularis and echinococcus granulosus genotype g1 (sheep strain) are sympatrically distributed in the plateau. in 1995, we identified a unique strobilate stage of echinococcus from the tibetan fox, vulpes ferrilata, but considered it to be a variant of e. multilocularis. subsequent molecular genetic studies revealed that a hydatid cyst from t ...	2006	16337180
control of hydatidosis.	control of hydatidosis is less effective without the support of dog-owners, and this support can only be obtained if the people have a clear understanding of the life-cycle of the hydatid parasite(s) and what risk factors contribute to human infections. dissemination of this information is the biggest challenge for hydatid control. participatory planning between dog-owners and community leaders should evaluate the possible control technologies, and should enable a choice of those aspects that su ...	2006	16387527
dual infection of animal hosts with different echinococcus species in the eastern qinghai-tibet plateau region of china.	the eastern qinghai-tibet plateau of china is a highly endemic region of echinococcosis where echinococcus granulosus sensu stricto (sheep strain), echinococcus multilocularis, and echinococcus shiquicus are distributed sympatrically. we developed a polymerase chain reaction-based restriction fragment length polymorphism (pcr-rflp) method for the identification of the three species in this region. the pcr-rflp showed the dual infection of animals with different echinococcus spp. the first case w ...	2006	16896135
cystic and alveolar echinococcosis: an epidemiological survey in a tibetan population in southeast qinghai, china.	an epidemiological investigation on echinococcosis was made in jiuzhi county of qinghai province, western china. ultrasonography and an indirect hemagglutination test revealed a morbidity of 8.0% (124/1,549) and a seroprevalence of 25.8% (287/1,113), respectively, in the tibetan population. the morbidity in herdsmen (16.6%) and buddhist priests (15%) was significantly higher than that in other occupation groups (3.2%), and it was higher in females (9.8%) than in males (6.2%). the ultrasound imag ...	2008	18503183
echinococcus granulosus infection and options for control of cystic echinococcosis in tibetan communities of western sichuan province, china.	human cystic echinococcosis (ce) is highly endemic in the tibetan regions of sichuan where most families keep guard dogs and where there are considerable numbers of ownerless/stray dogs. strong buddhist beliefs do not allow for elimination of stray dogs, and many strays are actually fed and adopted by households or monasteries. on account of the high altitude (3900-5000 m), pasturage is the major agricultural activity in this area. the harsh mountainous climate often leads to many grazing animal ...	2009	19399162
[investigation on echinococcosis in animals in gannan tibetan autonomous prefecture].	to make an investigation on echinococcosis among animals in gannan tibetan autonomous prefecture.	2009	19459495
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China.	Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province. Antiparasitic treatment with albendazole remains the primary choice for the great majority of patients in this resource-poor remote area, though surgery is the most common approach for CE therapy that has the potential to remove cysts and lead to complete cure. The current ...	2011	22039558
development of three pcr assays for the differentiation between echinococcus shiquicus, e. granulosus (g1 genotype), and e. multilocularis dna in the co-endemic region of qinghai-tibet plateau, china.	to investigate echinococcosis in co-endemic regions, three polymerase chain reaction (pcr) assays based on the amplification of a fragment within the nadh dehydrogenase subunit 1 (nd1) mitochondrial gene were optimized for the detection of echinococcus shiquicus, echinococcus granulosus g1, and echinococcus multilocularis dna derived from parasite tissue or canid fecal samples. specificity using parasite tissue-derived dna was found to be 100% except for e. shiquicus primers that faintly detecte ...	2013	23438764
surveillance of echinococcus isolates from qinghai, china.	echinococcosis is highly endemic over large parts of the qinghai-tibet plateau (qtp), china. based on a large number of samples, we present data on the current presence, host distribution, and genetic diversity of echinococcus in the qinghai province, located in the northeastern corner of the qtp and constituting >25% of the area of the plateau. we used 521 samples (including 451 newly collected samples and 70 samples from our previous study) from humans, yaks, sheep, goats, dogs, fox, plateau p ...	2015	25480467
discrimination between e. granulosus sensu stricto, e. multilocularis and e. shiquicus using a multiplex pcr assay.	infections of echinococcus granulosus sensu stricto (s.s), e. multilocularis and e. shiquicus are commonly found co-endemic on the qinghai-tibet plateau, china, and an efficient tool is needed to facilitate the detection of infected hosts and for species identification.	2015	26393793