Publications

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entomologic investigations of a chikungunya virus epidemic in the union of the comoros, 2005.from january to april 2005, an epidemic of chikungunya virus (chikv) illness occurred in the union of comoros. entomological studies were undertaken during the peak of the outbreak, from march 11 to march 31, aimed at identifying the primary vector(s) involved in transmission so that appropriate public health measures could be implemented. adult mosquitoes were collected by backpack aspiration and human landing collection in homes and neighborhoods of clinically ill patients. water-holding conta ...200818187788
chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?since 2004, several million indigenous cases of chikungunya virus disease occurred in africa, the indian ocean, india, asia and, recently, europe. the virus, usually transmitted by aedes aegypti mosquitoes, has now repeatedly been associated with a new vector, ae. albopictus. analysis of full-length viral sequences reveals three independent events of virus exposure to ae. albopictus, each followed by the acquisition of a single adaptive mutation providing selective advantage for transmission by ...200818304328
tracking epidemic chikungunya virus into the indian ocean from east africa.the largest documented outbreak of chikungunya virus (chikv) disease occurred in the indian ocean islands and india during 2004-2007. the magnitude of this outbreak led to speculation that a new variant of the virus had emerged that was either more virulent or more easily transmitted by mosquito vectors. to study this assertion, it is important to know the origin of the virus and how the particular strain circulating during the outbreak is related to other known strains. this study genetically c ...200818931072
aedes (diptera: culicidae) vectors of arboviruses in mayotte (indian ocean): distribution area and larval habitats.biological invasions generally induce profound effects on the structure of resident communities. in mayotte, where aedes aegypti and ae. lilii were already present, the recent introduction of ae. albopictus raises public health concerns because it may affect the risk of arbovirus transmission. entomological surveys were carried out in six locations on the island following a transect defined by a gradient from urban to rural habitats during a dry and a wet season. a total of 438 larval habitats c ...200919351070
chikungunya antibodies detected in non-human primates and rats in three indian ocean islands after the 2006 chikv outbreak.the role of terrestrial vertebrates in the epidemiology of chikungunya disease is poorly understood. we evaluated their exposure and amplification role during the 2006 chikungunya outbreak in the indian ocean. blood samples were collected from 18 mammalian and reptile species from reunion island, mauritius and mayotte. among the 1051 samples serologically tested for chikungunya virus (chikv), two crab-eating macaques (macaca fascicularis) and two ship rats (rattus rattus) proved to be exposed to ...201424885529
seroprevalence and risk factors of chikungunya virus infection in mayotte, indian ocean, 2005-2006: a population-based survey.background: since 2006, chikungunya virus (chikv) has re-emerged as an important pathogen of global concern. however, individual and household factors associated with the acquisition and the magnitude of clinically silent chikv infections remain poorly understood. in this present study, we aimed to investigate the seroprevalence, estimate the proportion of symptomatic illness and identify the risk factors for chikv infection in the primo-exposed population of mayotte. methods/ principal findings ...200818725980
[marseilles, the indian ocean and chikungunya virus].in recent decades marseilles, through immigration, has become the largest comorian city outside the archipelago. it is also home to a faculty of medicine that has made infectious diseases one of its fields of excellence. during the last two years, marseilles has spearheaded the metropolitan french response to the chikungunya crisis in the indian ocean region, and especially in the reunion island and mayotte. laveran military teaching hospital (hôpital d'instruction des armées, hia) has managed o ...200718225433
[chikungunya, la réunion and mayotte, 2005-2006: an epidemic without a story?].many triggering factors for onset of emerging infectious diseases are now recognised, such as: globalisation, demographic increase, population movements, international trade, urbanisation, forest destruction, climate changes, loss in biodiversity, and extreme life conditions such as poverty, famine and war. epidemic burden is often leading to disasters, in terms of human losses, as well as economic, political or social consequences. these outbreaks may jeopardize within a few weeks or months, in ...200717929405
outbreak of chikungunya in the french territories, 2006: lessons learned. 200717900426
seroprevalence of chikungunya virus infection on grande comore island, union of the comoros, 2005.an outbreak of chikungunya virus (chikv) illness associated with high fever combined with prolonged and severe arthralgias occurred on grande comore island from january through may 2005; 5,202 cases were reported. a seroprevalence study was conducted to define the extent of transmission on the island. we conducted a cross-sectional survey using a multistage sampling technique. a total of 481 households were sampled. in each household, one resident was selected randomly for interview and blood co ...200717556634
imported cases of chikungunya in metropolitan france, april 2005 - february 2006. 200616809828
[the unexpected chikungunya outbreak]. 200616697081
outbreak news. chikungunya and dengue, south-west indian ocean. 200616673456
epidemiology of chikungunya infection on reunion island, mayotte, and neighboring countries.since 2004, the frequency of chikungunya virus infections has been increasing in africa, indian ocean islands, and asia. the epidemic began on the kenyan coast, and reached the comoros at the end of 2004 before spreading to the south-western indian ocean islands (swioi) in 2005 and especially in 2006. the epidemic then spread to asia where epidemic foci are still active today. this increase also affected temperate zone countries where imported cases were reported, and indigenous transmission was ...201222280563
vector competence of aedes albopictus from virginia and georgia for chikungunya virus isolated in the comoros islands, 2005.we evaluated recently colonized samples from virginia and georgia (usa) of aedes albopictus, an important vector of chikungunya virus (chikv), to determine whether they became infected with and transmitted com125, a chikv isolate from the comoros islands. seven days after imbibing an infective blood meal containing a minimum of 8.5×10(4) plaque-forming units (pfu)/ml, 31-86% of a. albopictus from the counties of fairfax, loudon, rockingham, and suffolk, virginia, and fulton, georgia were infecte ...201222897347
genetic divergence of chikungunya virus plaque variants from the comoros island (2005).chikungunya virus (chikv) from a human sample collected during the 2005 chikungunya outbreak in the comoros island, showed distinct and reproducible large (l2) and small (s7) plaques which were characterized in this study. the parent strain and plaque variants were analysed by in vitro growth kinetics in different cell lines and their genetic similarity assessed by whole genome sequencing, comparative sequence alignment and phylogenetic analysis. in vitro growth kinetic assays showed similar gro ...201526347221
[the future of vector-borne infections in france]. 201121658555
field evaluation of clinical features during chikungunya outbreak in mayotte, 2005-2006.to record and assess the clinical features of chikungunya fever (chikf), with a view to enable diagnosis based on clinical criteria rather than costly laboratory procedures in field conditions.201020214759
the role of environmental and individual factors in the social epidemiology of chikungunya disease on mayotte island.this article examines the role of environmental and individual factors in the social epidemiology of chikungunya disease on the island of mayotte (south-western indian ocean). in an epidemic setting, an interdisciplinary study combining interviews, observations, and serological tests was conducted to: (1) estimate the frequency and social distribution of chikungunya disease and (2) identify its principal cognitive, behavioral, and environmental determinants within a stratified random sample of t ...200919121600
[confirmed chikungunya in children in mayotte. description of 50 patients hospitalized from february to june 2006].the french indian ocean island mayotte was hit by an outbreak of chikungunya in january 2005. the purpose of this retrospective study is to report data recorded over a five-month period (february - june 2006) in the pediatric-neonatal department of the hospital center in mayotte. the study cohort includes a total of 50 children in whom chikungunya was confirmed by molecular tools. mean age was 9.3 years and the male-to-female sex ratio was 1:5. the main symptoms were intense pain (88%), high fev ...200819068981
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