| frentizole, a novel immunosuppressive, and azathioprine: their comparative effects on host resistance to pseudomonas aeruginosa, candida albicans, herpes simplex virus, and influenza (ann arbor) virus. | frentizole, 1-(6-methoxy-2-benzothiazolyl)-3-phenyl urea, a new immunosuppressive agent, and azathioprine were administered subcutaneously at predetermined immunosuppressive dose levels of azathioprine and up to 50 times an immunosuppressive dose level of frentizole. after 10 days of treatment at these dose levels, the experimental groups were inoculated intraperitoneally with pseudomonas aeruginosa or herpes simplex virus, inoculated intraveneously with candida albicans, or infected by aerosol ... | 1977 | 188761 |
| characteristics of bacterial endocarditis in heroin addicts in detroit. | over 24 months (january 1972-december 1973) 48 intravenous heroin users were admitted to detroit general hospital with 50 episodes of bacterial endocarditis (b.e.). staphylococcus aureus (25 cases), enterococci (13 cases), and pseudomonas aeruginosa (5 cases) were the usual pathogens, accounting for 86 per cent of these illnesses. occasional episodes were due to other streptococci or diphtheroids which were susceptible to penicillin g. staphylococcal and pseudomonas endocarditis usually involved ... | 1976 | 1266890 |
| comparison of susceptibility to beta-lactam antimicrobial agents among bacteria isolated from intensive care units. | evaluating microbial isolation and susceptibility patterns from institutional settings is a well-established component of ongoing infection control activities. at the university of michigan hospitals, susceptibility profiles for selected bacteria tested from 1984 to 1989 were analyzed for major changes in the percentage of organisms susceptible to beta-lactam antimicrobials. data on bacteria isolated from respiratory specimens obtained from 1433 patients in intensive care units (icus) during a 1 ... | 1992 | 1737439 |
| major trends in the microbial etiology of nosocomial infection. | to determine trends in the microbial etiology of nosocomial infections in the 1980s, surveillance data on the microbiology of documented nosocomial infection reported to the national nosocomial infections surveillance system and from the university of michigan hospital were analyzed. antimicrobial susceptibility data on selected pathogens from both sources were also reviewed. overall, escherichia coli decreased from 23% of infections in 1980 to 16% in 1986-1989, klebsiella pneumoniae dropped fro ... | 1991 | 1928195 |
| characteristics of left-sided endocarditis due to pseudomonas aeruginosa in the detroit medical center. | mortality due to left-sided endocarditis caused by pseudomonas aeruginosa remains high despite the therapeutic regimen of high doses of an aminoglycoside plus a beta-lactam antibiotic. in this series, left-sided pseudomonal endocarditis presented as an acute illness refractory to optimal antibiotic therapy. complications associated with active valvular infection, such as neurologic sequelae, ring and annular abscesses, congestive heart failure, and splenic abscesses, are frequent. the overall mo ... | 1990 | 2385771 |
| nosocomial infection among patients in different types of intensive care units at a city hospital. | available data on the characteristics of infections in different types of icus are limited. between may and july 1984, overall infection rates of patients in the icus and in the general wards at the detroit receiving hospital were 19.2% and 9.8%, respectively (p less than .001). specific infection rates (number of infections/100 admissions in each unit) were 35.2% for surgical unit, 29.8% for burn unit, 13.9% for medical unit, and 6.6% for coronary unit. of the total number of patients admitted, ... | 1986 | 3698616 |
| bacteremia in narcotic addicts at the detroit medical center. ii. infectious endocarditis: a prospective comparative study. | for one year all narcotic addicts admitted to the detroit medical center with infectious endocarditis (74 cases) were compared with a control group of bacteremic addicts who had other infections (106 cases). endocarditis was caused by staphylococcus aureus (60.8% of cases), streptococci (16.2%), pseudomonas aeruginosa (13.5%), mixed bacteria (8.1%), and corynebacterium jk (1.4%). s. aureus endocarditis most frequently involved the tricuspid valve; streptococci infected left-sided valves signific ... | 1986 | 3755255 |
| retrospective evaluation of piperacillin use in a university hospital. | a retrospective review was conducted to evaluate the appropriateness of empiric and definitive piperacillin use and to determine if less expensive, more appropriate antibiotics could have been used. the criteria were approved by the chief of infectious diseases and the drug utilization review committee at this institution. one hundred courses of piperacillin use in adult patients were reviewed. therapy was categorized as appropriate in 78 of the 100 courses: 21 were appropriate empiric, 32 were ... | 1989 | 10292190 |
| evaluation of clinical practice guidelines on outcome of infection in patients in the surgical intensive care unit. | in this study, clinical practice guidelines were developed by a multidisciplinary team for patients with infections admitted to a surgical intensive care unit (icu). | 1999 | 10548192 |
| genetic diversity and multihost pathogenicity of clinical and environmental strains of burkholderia cenocepacia. | a collection of 54 clinical and agricultural isolates of burkholderia cenocepacia was analyzed for genetic relatedness by using multilocus sequence typing (mlst), pathogenicity by using onion and nematode infection models, antifungal activity, and the distribution of three marker genes associated with virulence. the majority of clinical isolates were obtained from cystic fibrosis (cf) patients in michigan, and the agricultural isolates were predominantly from michigan onion fields. mlst analysis ... | 2009 | 19542323 |
| resurgence of pseudomonas endocarditis in detroit, 2006-2008. | a resurgence of endocarditis due to pseudomonas aeruginosa was seen in 10 injection drug users (idus) in detroit between 2006 and 2008 (6 men, 4 women; mean age, 48.1 yr). all patients tested negative for the human immunodeficiency virus (hiv). five patients had left-sided endocarditis of the mitral valve and/or the aortic valve; 3 of 5 patients had prosthetic valve endocarditis. four of 10 patients had right-sided endocarditis of the tricuspid valve alone. one patient had bilateral involvement ... | 2009 | 19745688 |
| pseudomonas endocarditis in the detroit medical center. 1969-1972. | | 1973 | 20407410 |
| outcomes and genetic relatedness of carbapenem-resistant enterobacteriaceae at detroit medical center. | background.ôçâcarbapenem-resistant enterobacteriaceae (cre) are rapidly emerging in hospitals in the united states and are posing a significant threat. to better understand the transmission dynamics and the acquisition of resistant strains, a thorough analysis of epidemiologic and molecular characteristics was performed. methods.ôçâcre isolated at detroit medical center were analyzed from september 2008 to september 2009. bla(kpc) genes were investigated by polymerase chain reaction (pcr), and r ... | 2011 | 21828966 |
| pseudomonas aeruginosa respiratory tract infections associated with contaminated ultrasound gel used for transesophageal echocardiography—michigan, december 2011–january 2012. | | 2012 | 22912968 |
| pseudomonas aeruginosa respiratory tract infections associated with contaminated ultrasound gel used for transesophageal echocardiography - michigan, december 2011-january 2012. | in late december 2011, the department of epidemiology at beaumont health system (bhs) in royal oak, michigan, noted an increase in the number of positive respiratory cultures in one surgical intensive-care unit (icu), prompting further investigation. the increase in positive cultures was attributed entirely to pseudomonas aeruginosa. investigation by bhs staff members found that all of these positive cultures were related to use of ultrasound transmission gel from a single manufacturer during tr ... | 2012 | 22513528 |