Publications

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prevalence of extended spectrum beta lactamase producing gram negative bacteria in a tertiary care hospital.extended spectrum beta lactamase (esbl) producing gram negative bacteria are increasingly being associated with hospital infections thereby rendering all beta lactams, except carbapenems ineffective in the treatment of infections related to these organisms. a knowledge about their prevalence is essential to guide the appropriate antibiotic treatment of severe infections in hospitalized patients. the present work was carried out to study the prevalence of esbl producing gram negative bacteria in ...200212239838
characterization of pseudomonas aeruginosa isolated from chronically infected children with cystic fibrosis in india.pseudomonas aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (cf). with chronicity of infection, the organism resides as a biofilm, shows multi-drug resistance, diversifies its colony morphology and becomes auxotrophic. the patients have been found to be colonized with multiple genotypes. the present work was carried out to characterize p. aeruginosa isolated from children with cystic fibrosis using phenotypic and genotypic methods.200516033658
controlled trials of a polyvalent pseudomonas vaccine in burns.a polyvalent pseudomonas vaccine has been tested in controlled clinical trials at two burns units, in birmingham and new delhi, in children and adults with burns more than 15% full skin thickness. none of the vaccinated patients in either trial showed blood cultures containing pseudomonas aeruginosa, and vaccinees showed raised titres of protective antibody and increased phagocytic activity against ps. aeruginosa. in the new delhi unit, where death from ps. aeruginosa infection is common, the mo ...197991774
neonatal nosocomial infection: profile and risk factors.to determine the incidence and risk factors for neonatal nosocomial infections.19979332094
phenotypic & genotypic variants of pseudomonas aeruginosa isolated from children with cystic fibrosis in india.pseudomonas aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (cf). with increase in the chronicity of the disease, there is a diversification of the organism into different colony morphological types. the antimicrobial susceptibility of the organism varies with its colony morphology. the present work was carried out to study the different morphotypes of p. aeruginosa isolated from patients of cystic fibrosis.200212592994
pseudomonas aeruginosa carriage in semi-urban population of alipore village, delhi. 19826809609
detection of new delhi metallo beta lactamase-1 (ndm-1) carbapenemase in pseudomonas aeruginosa in a single centre in southern india.new delhi metallo β-lactamase-1 (ndm-1) producing pseudomonas aeruginosa isolates are potential threat to human health. this study was conducted to detect the presence of bla(ndm-1) in carbapenem resistant p. aeruginosa in a tertiary care center in southern india.201425488450
antimicrobial resistance in bacterial isolates from a delhi hospital: one year outcomes.antimicrobial resistance and hospital acquired infections have become an important public health issue. data on pathogen and antibiotic resistance is important for physicians, microbiologists and infection control officials but limited information on antibiotic resistance prevents pathogen specific therapy and propels antibiotic misuse. a retrospective review of bacterial isolation and antimicrobial susceptibility profiles in the in- and outpatients of a delhi hospital between january 2009-decem ...201425141553
trend analysis of antimicrobial consumption and development of resistance in non-fermenters in a tertiary care hospital in delhi, india.objectives multidrug-resistant pseudomonas aeruginosa and acinetobacter baumannii are becoming increasingly important nosocomial pathogens worldwide. to study the evolution of non-fermenters in a tertiary care hospital, we undertook a retrospective 10 year (1999-2008) trend analysis of antimicrobial consumption and resistance in non-fermenters causing bacteraemia. methods antibiotic consumption and resistance were analysed by linear regression. the pearson correlation coefficient was used for as ...201121586594
functional and structural characterization of the genetic environment of an extended-spectrum beta-lactamase blaveb gene from a pseudomonas aeruginosa isolate obtained in india.a pseudomonas aeruginosa clinical strain isolated from a patient hospitalized in a new delhi, india, hospital was resistant to expanded-spectrum cephalosporins, imipenem, and aztreonam. a bla(veb-1)-like gene named bla(veb-1a), which codes for the extended-spectrum beta-lactamase veb-1a, was identified. the genetic environment of bla(veb-1a) was peculiar: (i) no 5' conserved sequence (5'-cs) region was present upstream of the beta-lactamase gene, whereas bla(veb-1)-like genes are usually associa ...200415328086
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