| preliminary studies on the response of plasmodium falciparum to chloroquine in the philippines, with the in vitro technique. | previous investigations had shown that resistance to standard regimens of chloroquine occurred in some cases of falciparum infection in the philippines. more extensive investigations into this phenomenon were planned by the malaria eradication service, by means of the in vitro technique developed by rieckmann, in order to determine both the distribution of resistant strains throughout the country and their local incidence. before these studies were undertaken, a series of observations were made ... | 1976 | 791531 |
| in vitro drug response of plasmodium falciparum in the philippines: increased resistance to amodiaquine. | a long term study was carried out at san lazaro hospital, manila, philippines, monitoring the in vitro response of plasmodium falciparum to chloroquine, amodiaquine, mefloquine, and quinine. the in vitro effective dose giving 50% inhibition of schizogony was: 0.68 x 10(-6) m/liter blood for chloroquine; 0.18 x 10(-6) for amodiaquine; 0.2 x 10(-6) for mefloquine; and 1.12 x 10(-6) for quinine. the percent of isolates determined to be resistant in vitro was 85.2% for chloroquine, and 1.2% for both ... | 1987 | 3313737 |
| hla antigens and malaria at san lazaro hospital manila, philippines. | human leucocyte antigens (hla) were used as genetic markers in an attempt to determine possible host genetic susceptibility or resistance to malarial infections. hla-a and b typing on lymphocytes from 68 confirmed p. falciparum and 77 p. vivax cases was compared with that found in 66 control subjects with no known history of malaria. a significant deviation was observed in the distribution of hla-b27. this phenotype was absent in the p. falciparum group although found present in the p. vivax gro ... | 1984 | 6377512 |
| cerebral malaria at san lazaro hospital, manila, philippines. | forty cases of cerebral plasmodium falciparum malaria seen at san lazaro hospital, manila, philippines from 1979-1981 were reviewed. these cases represented 7% of all plasmodium falciparum cases seen during this period. all of the patients had fever and headache, 73% confusion, 70% chills, 68% jaundice or abdominal pain, 60% sweats. findings more frequent in the fatal compared to the non-fatal cases were: the presence of schizonts in the peripheral smear, oliguria, coma, convulsions, urinary inc ... | 1982 | 7170637 |
| malaria at san lazaro hospital, manila, philippines, 1979-1981. | results are presented from the 1,000 slide-confirmed malaria cases seen during the period august 1979-september 1981 at san lazaro hospital, in manila, philippines; 56% were caused by plasmodium falciparum, 38% by p. vivax, 6% were mixed infections, and 0.1% by p. malariae. the overall case fatality rate was 1%, all due to p. falciparum. cerebral involvement occurred in 7% and the case fatality rate was 20% compared to a case fatality rate of 0.2% among p. falciparum cases without cerebral invol ... | 1983 | 6340537 |
| studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among philippine strains of plasmodium falciparum. | one hundred cases of slide-confirmed plasmodium falciparum malaria admitted to the san lazaro hospital, manila, philippines were screened for in vitro resistance to chloroquine, quinine, amodiaquine and mefloquine using the microtechnique. 59 of the 100 primary parasite isolates produced schizonts, whereas the remaining 41 isolates did not. 51 of the 59 isolates tested were resistant in vitro to chloroquine and eight were sensitive. in contrast, three of the primary isolates were resistant to qu ... | 1985 | 3887681 |