| high prevalence of molecular markers for resistance to chloroquine and pyrimethamine in plasmodium falciparum from zimbabwe. | chloroquine has been the first line drug of treatment for malaria in zimbabwe until a recent adoption of an interim policy to treat using a combination of chloroquine (cq) and sulfadoxine/pyrimethamine (sp). we examined the prevalence of parasites with mutations associated with resistance to the drug combination in three areas that have been previously described to differ in malaria endemicity. our results show that the parasite population from the three areas had a high prevalence of molecular ... | 2007 | 17546463 |
| analysis of genetic polymorphism in select vaccine candidate antigens and microsatellite loci in plasmodium falciparum from endemic areas at varying altitudes. | plasmodium falciparum parasites obtained from symptomatic patients attending clinics in bindura (altitude 1100 m), chiredzi (600 m) and kariba (<600 m), previously reported to differ in malaria endemicity were genotyped on the msp-1, msp-2 and glurp loci to examine the extent of parasite genetic diversity. while the parasites were monomorphic for msp-1 allele ro33 from the three locations, the k1 allele was over-represented in kariba (p=0.02) and mad20 alleles occurred at a higher frequency in b ... | 2007 | 17568548 |
| antibody responses to plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude. | antibody levels against malaria antigens were measured among patients presenting with uncomplicated malaria at health centers from three locations in zimbabwe (bindura, chiredzi and kariba) that are distinct with regard to altitude and climatic conditions. antibody levels were determined by elisa using the antigens, apical membrane antigen 1 (ama-1), erythrocyte binding antigen 175 (eba-175), circumsporozoite surface protein (csp), merozoite surface protein 1 (msp-1) and pfg27. for all the antig ... | 2006 | 17113021 |