| plasmodium falciparum population structure in sudan post artemisinin-based combination therapy. | over the past decade, sudan has stepped up malaria control backed by who, and this has resulted in significant reduction in parasite rate, malaria morbidity and mortality. the present study analyzed plasmodium falciparum parasites in four geographical separated areas, to examine whether the success in malaria control following the use of artemisinin-based combination therapy (act) has disrupted the population structure and evolution of the parasite. we examined 319 p. falciparum isolates collect ... | 2015 | 25913735 |
| a perspective of the epidemiology of malaria and anaemia and their impact on maternal and perinatal outcomes in sudan. | both malaria and anaemia have adverse effects on maternal and perinatal outcomes. thus there is an urgent need to investigate the co-epidemiology of malaria and anaemia and their combined impact on maternal and perinatal outcomes in the different regions of sudan. | 2011 | 21389586 |
| identifying residual foci of plasmodium falciparum infections for malaria elimination: the urban context of khartoum, sudan. | identifying the location and size of residual foci of infections is critical where malaria elimination is the primary goal. here the spatial heterogeneity of plasmodium falciparum infections within the urban extent of khartoum state in sudan is investigated using data from cross-sectional surveys undertaken from 1999 to 2008 to inform the khartoum malaria free initiative (kmfi). | 2011 | 21373202 |
| fulminant hepatic failure in an african setting: etiology, clinical course, and predictors of mortality. | this is prospective cross-sectional study on 37 patients presenting to different hospitals in khartoum state, sudan, sought to determine the etiology, clinical course, and predictors of mortality in patients presenting with fulminant hepatic failure (fhf). patients were subclassified into hyperacute, acute, and subacute fhf; all sera were tested for hepatitis a, b, c, and e; negative samples were tested for antinuclear antibodies and anti-smooth muscle antibodies. the commonest etiologic factors ... | 2007 | 17436091 |
| in vitro processing of donors' blood with quinine for elimination of malaria parasites. | to eliminate malaria parasites in donors' blood in vitro for eradication of transfusion-induced malaria. | 2006 | 16830016 |
| high frequency of plasmodium falciparum pfcrt k76t and pfpghn86y in patients clearing infection after chloroquine treatment in the sudan. | the clinical response following treatment with chloroquine, and the prevalence of two plasmodium falciparum dna polymorphisms known to associate with drug resistance, namely pfcrt k76t and pfpgh n86y were investigated in two sites in central and eastern sudan. patient's sensitivity to chloroquine was determined according to the standard in vivo test as recommended by the who protocol in days 0, 3, 7 and 14, respectively. clinical un-responsiveness was 75.9% in gadaref in eastern sudan and 32.1% ... | 2006 | 16171768 |
| local differentiation in plasmodium falciparum drug resistance genes in sudan. | studies of population genetic structure of parasites can be used to infer which parasite genes are under selection. here, the population structure of 4 genes associated with drug resistance of plasmodium falciparum (the chloroquine resistance transporter, pfcrt, dihydrofolate reductase, dhfr, dihydropteroate synthase, dhps, and multi-drug resistance, pfmdr-1) were examined in parasite populations in 3 villages in eastern sudan and in an urban area of khartoum, the capital. in order to differenti ... | 2003 | 12793642 |
| a study of the urban malaria transmission problem in khartoum. | a study of malaria prevalence and transmission was carried out in khartoum, the capital of sudan. the sentinel sites were el manshia, an urban area on the blue nile and ed dekheinat, a lower-income peri-urban area bordering the white nile. anopheles arabiensis, the only malaria vector encountered, was present throughout the year although vector density varied seasonally. plasmodium falciparum was the only species found in el manshia. in ed dekheinat p. falciparum, plasmodium ovale and plasmodium ... | 2000 | 10708656 |
| evaluation of arthropod-borne viruses and other infectious disease pathogens as the causes of febrile illnesses in the khartoum province of sudan. | the relative importance of arthropod-borne and other disease pathogens as the cause of an outbreak of febrile illnesses was assessed during august 1988, following severe flooding in khartoum, sudan. a total of 200 patients with acute febrile illness and 100 afebrile controls were enrolled in the study during october and november 1988; at the omdurman military hospital, khartoum, sudan. sera were tested for igm and igg antibodies to six arthropod-borne viruses by an enzyme-linked immunoabsorbent ... | 1996 | 8835346 |
| induction of crisis forms in cultured plasmodium falciparum with human immune serum from sudan. | serums from 90 individuals from three areas in sudan were tested for inhibitory activity against cultures of plasmodium falciparum. in addition to inhibitory activity against merozoite invasion, all of the serums demonstrated, in varying degrees, the ability to retard intraerythrocyte development, leading to crisis forms and parasite deterioration. these retardation factors could be removed by absorption of immune serum with parasite-infected erythrocytes and were demonstrable in purified immuno ... | 1982 | 7043736 |
| response of falciparum malaria to a standard regimen of chloroquine in khartoum province, sudan. | | 1983 | 6368186 |
| association between human serum-induced crisis forms in cultured plasmodium falciparum and clinical immunity to malaria in sudan. | clinical histories with regard to falciparum malaria were collected from adults living in holo-, hyper-, and hypoendemic areas of sudan and matched to serum samples which were assayed for antiparasitic activity in cultures of plasmodium falciparum. the adult population of the endemic areas could be divided into three groups based on oral histories: those who never experience falciparum malaria; those with a childhood history of malaria, who experience only mild occasional malaria as adults; and ... | 1983 | 6350183 |
| clindamycin for the treatment of falciparum malaria in sudan. | clindamycin, 5 mg/kg twice a day for 5 days, was used to treat falciparum malaria after clinical and parasitological diagnosis at a health station in faki hashim, a suburb of khartoum, sudan. twenty out of twenty-six patients enrolled completed the study. giemsa-stained thick blood films were negative for asexual parasites by day 7 in 17 patients and by day 8 in the remaining 3. all were examined on days 14 or 28; 2 who had initially been cleared by day 6 had asymptomatic low density asexual par ... | 1985 | 3914844 |
| cell-mediated immune responses to plasmodium falciparum purified soluble antigens in sickle-cell trait subjects. | to determine the possible differences in the immune response to plasmodium falciparum between sickle-cell trait (hb as) and normal haemoglobin (hb aa) individuals, we examined 35 hb as and 24 hb aa subjects matched for age and microenvironment. their age was 2-55 years and all lived in a malaria endemic area 300 km south of khartoum. antibodies to ring-infected erythrocyte surface antigen (pf155/resa) and to circumsporozoite (cs) protein (anti-nanp40) indicated equal exposure to falciparum malar ... | 1990 | 2283154 |
| chloroquine-resistant plasmodium falciparum isolates from the sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance. | isolates of plasmodium falciparum from 3 areas of the sudan were recovered from cryopreservation in london and their chloroquine sensitivity was determined in vitro. chloroquine resistance was detected in 6/6 isolates from khartoum, 1/4 from sennar and 3/3 from gadarif, indicating that resistance is spreading. all the isolates were sensitive to mefloquine. studies using blood spots on glass fibre discs and the polymerase chain reaction did not detect two mutations in the pfmdr1 gene, thought to ... | 1992 | 1287907 |