long-term care facilities: a cornucopia of viral determine the frequency and types of respiratory viruses circulating in boston long-term care facilities (ltcfs) during a 3-year period.200818557966
predictors of respiratory failure among previously healthy children with respiratory syncytial virus infection.respiratory syncytial virus (rsv)-related disease is the leading cause of hospitalization among infants, with approximately 7% to 21% of these patients developing acute respiratory failure.201120825782
prevention of nosocomial transmission of respiratory syncytial virus in a newborn nursery.during three winter seasons prior to 1984-1985 the special care nursery at new england medical center experienced respiratory syncytial virus (rsv) epidemics that required closure of the unit. prior to and during the 1984-1985 winter season, several measures were taken to prevent recurrent nosocomial rsv transmission. in the winters of 1984-1985 and 1985-1986 there were 26 introductions of community-acquired rsv with no transmission of nosocomial cases during 1,688 patient days at risk as compar ...19883351266
prevalence of respiratory syncytial virus subgroups over six consecutive outbreaks: 1981-1987.indirect immunofluorescence with strain-specific monoclonal antibodies was used to determine the phenotype of respiratory syncytial virus (rsv) isolates obtained from infants hospitalized in greater boston over six successive outbreaks from 1981 to 1987. of 981 isolates, 591 (60%) were classified as subgroup a and 383 (39%) as subgroup b. the prevalence of subgroups varied both between and within yearly outbreaks. in 1983-84 and 1984-85, both subgroups circulated concurrently and in almost equal ...19892760479
concurrent circulation of antigenically distinct strains of respiratory syncytial virus during community outbreaks.respiratory syncytial virus (rsv) is considered to be of a single serotype. antigenic variants are detectable both by neutralization and monoclonal antibodies and have been divided into two broad categories, groups 1 and 2. group 2 isolates have been considered to be uncommon. we used indirect immunofluorescence with strain-specific monoclonal antibodies to study rsv isolates from hospitalized infants in the greater boston area. of 223 rsv isolates recovered over a five-month period in 1983-1984 ...19862418126
validation of syndromic surveillance for respiratory infections.a key public health question is whether syndromic surveillance data provide early warning of infectious outbreaks. one cause for skepticism is that biological correlates of the administrative and clinical data used in these systems have not been rigorously assessed. this study measures the value of respiratory data currently used in syndromic surveillance systems to detect respiratory infections by comparing it against criterion standard viral testing within a pediatric population.200616492494
human metapneumovirus in children tested at a tertiary-care hospital.respiratory infections are the leading cause of outpatient visits in the united states, but the etiology of many of these infections is unknown. human metapneumovirus (hmpv) is a recently discovered virus that causes respiratory infections.200415195239
reduced risk of neonatal respiratory infections among breastfed girls but not boys.the effect of breastfeeding on community-acquired neonatal infections has not been well studied, although the neonatal period is one of special vulnerability to infectious pathogens. respiratory tract infections are the neonatal infection most commonly diagnosed after nursery discharge. we therefore chose respiratory tract infections diagnosed after nursery discharge as representative of neonatal community-acquired infection and studied the impact of breastfeeding on this neonatal infection synd ...200314523216
a simultaneous outbreak of respiratory syncytial virus and parainfluenza virus type 3 in a newborn nursery.over a 3-week period, 20 of 34 (59%) infants in a newborn nursery developed nosocomial viral respiratory tract disease. either respiratory syncytial virus (seven infants) or parainfluenza virus type 3 (five) or both (two) were demonstrated in respiratory secretions from 14 of the 20 symptomatic patients. symptoms in the 20 infants included rhinitis (15 infants), cough (14), apnea (eight), pulmonary infiltrates (seven), and fever (six). there were no differences in symptoms between children infec ...19846325655
relative impact of influenza and respiratory syncytial virus in young children.we measured the relative impact of influenza and respiratory syncytial virus (rsv) infections in young children in terms of emergency department (ed) visits, clinical care requirements, and overall resource use.200919933730
influenza and other respiratory virus-related emergency department visits among young children.influenza and other winter respiratory viruses cause substantial morbidity among children. previous estimates of the burden of illness of these viruses have neglected to include the emergency department, where a large number of patients seek acute care for respiratory illnesses. this study provides city- and statewide population estimates of the burden of illness attributable to respiratory viruses for children receiving emergency department-based care for respiratory infections during the winte ...200616818524
hypertensive rats are susceptible to tlr4-mediated signaling following exposure to combustion source particulate matter.toll-like receptor 4 (tlr4) has been shown to play a role in cell signaling that results in neutrophilic inflammation in response to lipopolysaccharide and respiratory syncytial virus infection. tlr4 also interacts with cd14, which upon complex formation triggers tlr4-associated signaling pathways to produce a proinflammatory response. this mechanism results in the activation of nf-kappa b and subsequent inflammatory gene induction. in order to determine the effect of combustion source particle ...200415204789
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