| sensitivity of neisseria meningitidis to sulfonamides and antibiotics. in vitro trials on 302 strains isolated during the brazilian epidemic of 1974. | during the recent epidemic of meningitis in brazil, 1974, bacteriological and antibiotic sensitivity investigations were performed on 302 strains of neisseria meningitidis, isolated from meningitis patients from the são paulo and rio de janeiro districts in the first half of 1974. the experiments have shown that 58% of the strains belong to the serological type a, 25% belong to type c and the remaining 17% to a group designated 'untypable' in that they did not react with the diagnostic antisera ... | 1977 | 401724 |
| epidemic disease due to serogroup c neisseria meningitidis in saõ paulo, brazil. | | 1974 | 4207309 |
| maternal and infant antibody response to meningococcal vaccination in pregnancy. | the antigenic capacity of a mixed vaccine prepared with polysaccharides of meningococcus groups a and c, the placental transfer of antibodies, and the persistence of positive titres in the infant were evaluated in 21 pregnant women and their offspring during an epidemic of meningitis in são paulo, brazil; and antibody response was assessed in 29 infants vaccinated at less than 6 months of age. antibodies were detected by passive haemagglutination; the high titres found and the high frequency of ... | 1977 | 71611 |
| protective efficacy of a serogroup b meningococcal vaccine in sao paulo, brazil. | serogroup b neisseria meningitidis is the most common cause of epidemic meningococcal disease in developed countries. until recently no vaccine has been available for prevention of infection with this organism. in an attempt to control epidemic serogroup b meningococcal disease in greater sao paulo, brazil, during 1989 and 1990, a cuban-produced outer-membrane-protein-based serogroup b meningococcal vaccine was given to about 2.4 million children aged from 3 months to 6 years. we have done a cas ... | 1992 | 1357461 |
| use of cerebrospinal fluid and serum samples impregnated on ftatm elute filter paper for the diagnosis of infections caused by neisseria meningitidis, streptococcus pneumoniae and haemophilus influenzae. | the lack of information regarding the burden of acute bacterial meningitis in latin america leads to a reduction in the estimated incidence rates of the disease, and impairs public health decisions on the use and follow-up of preventive interventions, particularly, the evaluation of existing vaccination policies. the use of the real-time pcr in diagnostic routine procedures has resulted in a substantial increase in confirmed bacterial meningitis cases. however, in resource-poor countries, these ... | 2017 | 28235065 |
| incorporation of real-time pcr into routine public health surveillance of culture negative bacterial meningitis in s+úo paulo, brazil. | real-time (rt)-pcr increases diagnostic yield for bacterial meningitis and is ideal for incorporation into routine surveillance in a developing country. we validated a multiplex rt-pcr assay for streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae in brazil. risk factors for being culture-negative, rt-pcr positive were determined. the sensitivity of rt-pcr in cerebrospinal fluid (csf) was 100% (95% confidence limits, 96.0%-100%) for n. meningitidis, 97.8% (85.5%-99.9%) fo ... | 2011 | 21731621 |
| antimicrobial susceptibility of neisseria meningitidis strains isolated from meningitis cases in brazil from 2006 to 2008. | to analyze the profile of antimicrobial susceptibility of meningococcal disease isolates collected throughout brazil from 2006 to 2008 and forwarded to the national reference laboratory for meningitis, institute adolfo lutz - são paulo. | 2011 | 21345528 |
| production of monoclonal antibodies against neisseria meningitidis using popliteal lymph nodes and in vivo/in vitro immunization: prevalence study of new monoclonal antibodies in greater são paulo, brazil. | a rapid and efficient method for preparing monoclonal antibody (mab) serotypes using neisseria meningitidis outer membrane were used in balb/c mouse footpads for the immunization. the popliteal lymph nodes were isolated 19 days later for mab-producing hybridomas, from which the mabs against the 37 kda protein were screened. variations in class 2/3 (porb) proteins form the basis for meningococcal serotyping. this is the first report on the preparation of mabs against n. meningitidis that is speci ... | 2007 | 17979546 |
| clonal distribution of invasive neisseria meningitidis serogroup c strains circulating from 1976 to 2005 in greater sao paulo, brazil. | meningococcal disease is characterized by cyclic fluctuations in incidence, serogroup distribution, and antigenic profiles. in greater são paulo, brazil, there has been a constant increase in the incidence of serogroup c meningococcal disease since the late 1980s. to gain an understanding of changes in serogroup c meningococcal disease over three decades in greater são paulo, brazil, 1,059 invasive neisseria meningitidis serogroup c isolates from 1976 and 2005 were analyzed. three major clone co ... | 2007 | 17314227 |
| meningococcal conjugate vaccines: efficacy and new combinations. | meningococcal disease continues to be a serious public health concern, being associated with high morbidity and mortality rates worldwide, particularly in brazil. in addition to discussing recent changes in the global epidemiology of meningococcal disease, we also analyze the development and impact of new conjugate vaccines on the prevention of meningococcal disease, with emphasis on the different immunization strategies implemented with these vaccines. | 2006 | 16826310 |
| [mass vaccination campaign against serogroup c meningococcal disease, municipality of itapeva, sao paulo]. | | 2005 | 15654472 |
| [meningococcal disease diagnostic criteria in greater metropolitan campinas, são paulo state, brazil]. | the aim of this article is to evaluate confirmatory criteria: culture, latex agglutination, counter immunoelectrophoresis, microscopic examination, and clinical/epidemiological criteria for cases of meningococcal disease reported in greater metropolitan campinas, são paulo state, brazil, from 1993 to 2002 (568 cases). the following variables were also studied: clinical features, gender, age, city, hospital, case fatality, seasonality, and neisseria meningitidis serogroup. culture as a confirmato ... | 2004 | 15608854 |
| [fatality rate in the epidemiology of meningococcal disease: study in the region of campinas, sp, brazil, 1993 to 1998]. | to analyze the trends of the meningococcal disease cumulative incidence and case-fatality rate in the region of campinas, brazil, an area that encircles five cities and 1.2 million inhabitants, from 1993 to 1998. | 2000 | 11175603 |
| meningococcal disease caused by neisseria meningitidis serogroup b serotype 4 in são paulo, brazil, 1990 to 1996. | a large epidemic of serogroup b meningococcal disease (md), has been occurring in greater são paulo, brazil, since 1988. a cuban-produced vaccine, based on outer-membrane-protein (omp) from serogroup b: serotype 4: serosubtype p1.15 (b:4:p1.15) neisseria meningitidis, was given to about 2.4 million children aged from 3 months to 6 years during 1989 and 1990. the administration of vaccine had little or no measurable effects on this outbreak. in order to detect clonal changes that could explain th ... | 1998 | 9755558 |
| genetic structure of neisseria meningitidis serogroup c epidemic strains in south brazil. | in the present study we report the results of an analysis, based on serotyping, multilocus enzyme electrophoresis (mee), and ribotyping of n. meningitidis serogroup c strains isolated from patients with meningococcal disease (md) in rio grande do sul (rs) and santa catarina (sc) states, brazil, as the center of epidemiology control of ministry of health detected an increasing of md cases due to this serogroup in the last two years (1992-1993). we have demonstrated that the md due to n.meningitid ... | 1995 | 8599055 |
| characterization of epidemic neisseria meningitidis serogroup c strains in several brazilian states. | epidemic strains of the neisseria meningitidis c:2b:p1.3 electrophoretic type 11 complex were responsible for an outbreak in curitiba, parana state, brazil, from 1990 to 1991. strains of this complex were also isolated in other brazilian states and were responsible for a meningococcal disease epidemic in são paulo state in 1990. serotyping both with monoclonal antibodies and by multilocus enzyme electrophoresis was useful for typing these epidemic strains related to the increased incidence of me ... | 1994 | 7929775 |
| [meningitis. 6,957 cases confined at the "emilio ribas" hospital (são paulo) during the 1958-1967 decade. occurrence, etiology and mortality]. | | 1970 | 4393708 |
| [meningococcal meningitis in sao paulo, brazil]. | | 1974 | 4216584 |
| ongoing group b neisseria meningitidis epidemic in são paulo, brazil, due to increased prevalence of a single clone of the et-5 complex. | beginning in 1988, the incidence of meningococcal disease in the area of greater são paulo began to surpass the upper confidence limit of an 8-year average incidence (from 1979 to 1986), thus characterizing a new epidemic in the region of greater são paulo. this epidemic, which extended to 1990, was different from previous epidemics in that it was caused by serogroup b. the increased incidence of meningococcal disease was paralleled by an increased prevalence of a single group b clone, b:4:p1.15 ... | 1992 | 1629328 |
| emergence of a new clone of serogroup c neisseria meningitidis in são paulo, brazil. | serogroup c isolates of neisseria meningitidis recovered from 121 patients with meningitis or septicemia in greater são paulo, brazil, between 1976 and 1990 were analyzed with respect to serotype and multilocus enzyme genotype. the distribution of serotypes has changed since 1989 when serotype 2b started to replace serotype 2a. there were 48 distinct multilocus genotypes (electrophoretic types [ets]) and 13 distinct complexes. among the 41 serotype c:2b:- strains analyzed, 38 (93%) were found in ... | 1992 | 1583132 |