Publications

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[the ratios and kinds of clinical bacteria isolated in taiwan's large-size hospitals].the prevalence of clinical bacteria, as isolated from linko chang-gung memorial hospital (2,300 beds) in the period january 1985 to december 1986 and from taipei veterans general hospital (2,300 beds) during the period january 1986 to december 1986, was analyzed with the following findings: (i) the isolation ratio of anaerobic and aerobic or facultative bactria during the period of investigation were 7.8% (5,513/70,799) and 92.2% (65,286/70,799), respectively. (ii) of the total aerobic or facult ...19892791722
multicenter surveillance of antimicrobial resistance of major bacterial pathogens in intensive care units in 2000 in taiwan.a susceptibility surveillance study of 1,274 bacterial isolates recovered from various clinical specimens from patients in intensive care units (icus) of five major teaching hospitals was carried out from march, 2000, to june, 2000, in taiwan. this study demonstrated a high rate (66%) of oxacillin resistance in staphylococcus aureus (orsa), a high rate of nonsusceptibility to penicillin (intermediate, 50% and highly resistant, 8%), and high rates of cefotaxime nonsusceptibility for s. pneumoniae ...200111822777
antimicrobial susceptibilities among clinical isolates of extended-spectrum cephalosporin-resistant gram-negative bacteria in a taiwanese university hospital.infections caused by gram-negative bacteria with resistance to extended-spectrum cephalosporins require the identification of effective alternative antimicrobial therapy. to determine the role of other pre-existing or currently available antimicrobial agents in treating infections caused by these multidrug-resistant pathogens, we evaluated the in vitro susceptibilities of these agents in 411 non-duplicate isolates of extended-spectrum cephalosporin-resistant gram-negative bacteria recovered betw ...200211751769
metallo-beta-lactamase-producing enterobacteriaceae isolates in a university hospital in taiwan: prevalence of imp-8 in enterobacter cloacae and first identification of vim-2 in citrobacter freundii.a total of 9082 clinical isolates of enterobacteriaceae other than klebsiella spp. collected in 1999 and 2000 at a university hospital in taiwan were investigated for the production of metallo- beta-lactamases (mbls). thirty-six (2.9%) of the 1261 enterobacter cloacae isolates and one (0.3%) of the 340 citrobacter freundii isolates were found to carry bla(imp-8) and bla(vim-2), respectively, by colony hybridization, pcr and sequence analysis. the imp-8 producers were recovered from 20 patients a ...200212356794
cefotaxime-resistant citrobacter freundii in isolates from blood in a tertiary teaching hospital in northern taiwan.from january 2002 to december 2003, 12 patients in a tertiary teaching hospital in northern taiwan had bloodstream infections caused by citrobacter freundii. seven of the 12 isolates were resistant to cefotaxime. using polymerase chain reaction and dna sequencing, 3 of the 7 cefotaxime-resistant c. freundii isolates were found to carry extended-spectrum beta-lactamase (esbl). ampc beta-lactamase genes were also detected in all strains of c. freundii. all strains of c. freundii with mics >or=4 mg ...200717572502
in vitro activity of isepamicin and other aminoglycosides against clinical isolates of gram-negative bacteria causing nosocomial bloodstream infections.isepamicin is a newly introduced aminoglycoside in taiwan. since in vitro data for isepamicin against nosocomial gram-negative bloodstream infection from taiwan are limited, we compared the activity of isepamicin, amikacin, gentamicin and tobramycin against nosocomial gram-negative blood isolates.200718087627
in vitro susceptibilities of clinical isolates of ertapenem-non-susceptible enterobacteriaceae to cefotaxime, ceftazidime, cefepime and aztreonam.to investigate the in vitro susceptibility of ertapenem-non-susceptible enterobacteriaceae (ense) isolates to cefotaxime, ceftazidime, cefepime and aztreonam.201222345386
bloodstream infections caused by imp-8-producing enterobacteriaceae isolates: the need for clinical laboratory detection of metallo-β-lactamases?a retrospective study was conducted at a taiwanese medical center to characterize bloodstream infections caused by imp-8 metallo-β-lactamase (mbl)-producing enterobacteriaceae isolates and to assess the need for laboratory detection of imp producers. we analyzed 37 patients infected with imp-8 producers (two escherichia coli, nine klebsiella pneumoniae, 25 enterobacter cloacae, and one citrobacter freundii) and 107 patients infected with non-imp-8 producers (eight e. coli, 26 k. pneumoniae, 70 e ...201323001510
characterization of the modified hodge test-positive isolates of enterobacteriaceae in taiwan.the modified hodge test is a phenotypic test to detect kpc-type carbapenemase producers among enterobacteriaceae, as recommended by the clinical laboratory standards institute. however, false positive results were reported. in this study, we aimed to large-scale investigate the characterization of the modified hodge test-positive isolates of enterobacteriaceae collected between 2006 and 2010 in taiwan.201322578642
severe bacterial infection in patients with heterotaxy syndrome.to determine the incidence of sepsis in patients with heterotaxy syndrome.201424112867
carbapenem-nonsusceptible enterobacteriaceae in taiwan.a total of 1135 carbapenem-resistant (nonsusceptible) enterobacteriaceae (cre) isolates were recovered between november 2010 and july 2012 (517 from 2010-2011 and 618 from 2012) from 4 hospitals in taiwan. carbapenemase-producing enterobacteriaceae (cpe) comprised 5.0% (57 isolates), including 17 kpc-2 (16 klebsiella pneumoniae and 1 escherichia coli), 1 ndm-1 (k. oxytoca), 37 imp-8 (26 enterobacter cloacae, 4 citrobacter freundii, 4 raoultella planticola, 1 k. pneumoniae, 1 e. coli and 1 k. oxy ...201525794144
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