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[acute febrile disease with splenomegaly and pancytopenia. a 66-year-old greek patient with a prosthetic mitral valve].we report on a 66-year-old patient originating from greece and living in germany with a prosthetic mitral valve because of a combined vitium following juvenile rheumatic fever. the patient fell ill with acute fever, splenomegaly, and pancytopenia. after unsuccessful antibiotic therapy because of presumed endocarditis or sepsis with unknown focus, visceral leishmaniasis was suspected because of recent travel to greece. subsequently, this diagnosis was confirmed by serology. considering thrombocyt ...200717541531
molecular detection of leishmania infantum in wild rodents (rattus norvegicus) in greece.leishmania infantum and leishmania tropica are the species responsible for visceral leishmaniasis and cutaneous leishmaniasis respectively. in greece, both diseases are endemic. the dog is considered the main reservoir of l. infantum, whereas the role of other animals for both l. infantun and l. tropica is unknown. spleens from wild rattus norvegicus, live trapped in greece, were examined for the presence of leishmania parasites by pcr. out of 16 samples examined, only one was found positive for ...201019912600
successful treatment of imported mucosal leishmania infantum leishmaniasis with miltefosine after severe hypokalemia under meglumine antimoniate treatment.old world mucosal leishmaniasis is a rare but regularly reported disease in southern europe. we report the case of a 64-year-old woman who developed severe hypokalemia under meglumine antimoniate treatment and was successfully treated under second line therapy with miltefosine.201122414039
the use of spatial analysis to estimate the prevalence of canine leishmaniasis in greece and cyprus to predict its future variation and relate it to human disease.climatic, environmental, and demographic changes favor the emergence of neglected vector-borne diseases like leishmaniasis, which is spreading through dogs, the principle host of the protozoan leishmania infantum. surveillance of the disease in dogs is important, because the number of infected animals in an area determines the local risk of human infection. however, dog epidemiological studies are costly. our aim was to evaluate the emerging diseases in a changing european environment (eden) vet ...201424957543
serological investigation for west nile virus, anaplasma ovis and leishmania infantum in greek cattle.this study investigates the seroprevalence of greek adult cattle against west nile virus, anaplasma ovis and lehismania infantum. in total, 156 serum samples were examined, drawn from cattle between 2-4 years old. all the examined cattle originated from slaughterhouses of 4 prefectures in northern greece (thessaloniki, pella, chalkidiki, kilkis), in 2 of which (thessaloniki, pella) human cases of west nile virus had been recorded some months before. thirty out of the 156 (18.6%) samples have tes ...201526455373
selection of appropriate serological tests to measure the incidence of natural leishmania infantum infection during dna/mva prime/boost canine vaccine trials.in response to the increasing need for field trials of experimental dna vaccines against zoonotic visceral leishmaniasis in dogs, our aim was to validate the use of elisa protocols which will be suitable for detection of natural infection in vaccinated dogs. we have previously demonstrated that dna/modified vaccinia virus ankara (mva) vaccine expressing tryparedoxin peroxidase (tryp) induced high titres of tryp antigen-specific igg in immunized dogs. here we report our findings that seroconversi ...200919386420
molecular diagnosis of leishmaniosis in dogs. comparative application of traditional diagnostic methods and the proposed assay on clinical samples.leishmaniosis is a zoonotic, parasitic disease caused by members of the genus leishmania. the disadvantages of the traditional methods have currently rendered the polymerase chain reaction (pcr), the most reliable alternative for the laboratory diagnosis of this disease. several relevant protocols have been described in the past but their application is in most cases limited to research use. the latter combined with the diagnostic problems that can be caused by the genetic variability of the dif ...200312695035
human and canine leishmaniasis in asymptomatic and symptomatic population in northwestern greece.the occurrence of human and canine mediterranean visceral leishmaniasis (mvl) in northwestern greece was investigated during an 8-year survey (1994-2001). a total of 1200 blood sera samples, collected from asymptomatic human population, and 1200 blood sera samples from asymptomatic dogs were screened for leishmania infantum antibodies using the indirect immunofluorescence test (ifa). also during the survey 111 human subjects and 350 canines were referred as clinically suspect cases for mvl. sign ...200515603841
water wells as a habitat of sand fly (diptera: psychodidae) vectors of visceral leishmaniasis in greece.overall, 37 of 79 water wells in 3 diverse geographic areas of greece were found to harbor sand flies. the predominant species were phlebotomus tobbi adler, theodor & lourie and p. neglectus tonnoir, species implicated in the transmission of leishmania infantum nicolle. three additional species of phlebotomus and 2 sergentomyia spp. also encountered. wells appear to be resting and possibly breeding habitat for sand flies in greece.19968742534
leishmaniasis in greece i. isolation and identification of the parasite causing human and canine visceral leishmaniasis.three human and 19 canine leishmanial stocks were typed according to their excreted factor serotype and the electrophoretic mobility of their mdh, gpi, g6pdh and 6pgdh and shown to be identical with regard to these characters and, thus with leishmania donovani infantum. this verifies the opinion of earlier researchers, who suggested that the parasites which cause human and canine visceral leishmaniasis in greece are the same organism and that dogs are the reservoir for the human infection. the c ...19846383236
isolation and typing of leishmania infantum from phlebotomus neglectus on the island of corfu, greece. 19883232178
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