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is nausea associated with chronic hepatitis c infection?hepatitis c virus is a common chronic infection that is widely associated with symptoms of fatigue and pain in the right upper quadrant. nausea may be an underrecognized symptom. this study was designed to study the frequency of nausea in patients with hepatitis c virus infection compared to controls.200111774949
hepatitis c virus infection among firefighters, emergency medical technicians, and paramedics--selected locations, united states, 1991-2000. 200010943253
functional restoration of hcv-specific cd8 t cells by pd-1 blockade is defined by pd-1 expression and compartmentalization.the immunoinhibitory receptor programmed death-1 (pd-1) is up-regulated on dysfunctional virus-specific cd8 t cells during chronic viral infections, and blockade of pd-1/pd-ligand (pd-l) interactions can restore their function. as hepatitis c virus (hcv) persists in the liver with immune-mediated disease pathogenesis, we examined the role of pd-1/pd-l pathway in antigen-specific cd8 t-cell dysfunction in the liver and blood of hcv-infected patients.200818549878
effect of race and hiv co-infection upon treatment prescription for hepatitis c virus.treatment rates for hepatitis c virus (hcv) have not been compared directly between hcv mono-infected and hcv-hiv co-infected patients in academic center settings.200918993100
potential transmission of viral hepatitis through use of stored blood vessels as conduits in organ transplantation--pennsylvania, 2009.solid organ transplantation sometimes requires the use of blood vessels from a deceased donor as conduits to connect transplanted organ vessels to recipient vessels. vessels not immediately used are sometimes stored for later use, including vessels collected from hepatitis b virus (hbv) and hepatitis c virus (hcv) seropositive donors; hbv and hcv seropositive vessels can be stored for use in seropositive recipients. in may 2009, hcv was transmitted when a transplant facility inadvertently used a ...201121330966
epidemiology of hepatitis c virus in pennsylvania state prisons, 2004-2012: limitations of 1945-1965 birth cohort screening in correctional settings.we described hepatitis c virus antibody (anti-hcv) prevalence in a state prison system and retrospectively evaluated the case-finding performance of targeted testing of the 1945 to 1965 birth cohort in this population.201424825235
integrating routine hcv testing in primary care: lessons learned from five federally qualified health centers in philadelphia, pennsylvania, 2012-2014.an estimated 2.7-3.9 million americans are infected with hepatitis c virus (hcv). despite being the most common blood-borne virus in the united states, routine hcv testing is not commonly practiced. to address this gap, we measured the impact of integrated routine hcv testing on patient care.201727168664
atherosclerotic heart disease: prevalence and risk factors in hospitalized men with haemophilia a.atherosclerotic heart disease (ashd) is a common cause of morbidity and mortality in western society. few studies have determined prevalence and predictors of ashd in haemophilia (ha), a population whose survival is improving with safer blood products and effective treatments for aids and hepatitis c. the purpose of this study was to determine prevalence and factors associated with ashd in haemophilia a patients in pennsylvania. the prevalence of ashd (myocardial infarction, angina and coronary ...201121371197
long-term disease and economic outcomes of prior authorization criteria for hepatitis c treatment in pennsylvania medicaid.several highly effective but costly therapies for hepatitis c virus (hcv) are available. as a consequence of their high price, 36 state medicaid programs limited treatment coverage to patients with more advanced hcv stages. states have only limited information available to predict the long-term impact of these decisions.201627932263
risk of hip fracture associated with hepatitis c virus infection and hepatitis c/human immunodeficiency virus coinfection.hepatitis c virus (hcv) infection has been associated with reduced bone mineral density, but its association with fracture rates is unknown, particularly in the setting of human immunodeficiency virus (hiv) coinfection. our aims were to determine whether persons with hcv infection alone are at increased risk for hip fracture, compared to uninfected individuals, and to examine whether the risk of hip fracture is higher among hcv/hiv-coinfected persons, compared to those with hcv alone, those with ...201222619086
infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil.mycophenolate mofetil (mmf) is a new immunosuppressive agent that is gaining widespread use in solid organ transplantation recipients. a comprehensive assessment of infectious complications after its use after liver transplantation has never been assessed.19989753337
aggressive use of ribavirin and prolonged course of peginterferon to improve the rate of viral response in liver transplant patients with recurrent hepatitis c viral infection.there are different approaches for treating recurrent hepatitis c viral infection after a liver transplant. however, sustained virologic response is achieved in < 40% of infected allografts. we examined sustained virologic response improvement using a prolonged course of peginterferon and aggressive use of ribavirin.201020716039
the oklahoma-pittsburgh experience with interferon alpha in the treatment of hcv disease.interferon alpha (ifn) is the only food and drug administration (fda)-approved therapy available for the treatment of chronic hepatitis c. the ideal dose and frequency of ifn administration that produces the greatest number of patient responders with the least number of relapses following drug withdrawal remains unclear. methods. one hundred seventeen patients recruited over a five-year period with chronic hepatitis c were divided into four groups and treated with progressively larger doses. the ...19957782963
the clinical and morphologic spectrum of renal cryoglobulinemia.we review the clinical and histologic features of 17 patients with cryoglobulinemia and renal disease. most cases were associated with evidence of hepatitis c virus (hcv), although a significant minority had no evidence of hcv. the most common histologic pattern for renal involvement was membranoproliferative glomerulonephritis, which was seen in both hcv-positive and hvc-negative patients. clinical presentation was variable, including nephrotic syndrome, unexplained elevations of serum creatini ...200212352634
characterizing the burden of hepatitis c infection among entrants to pennsylvania state prisons, 2004 to 2012.although hepatitis c (hcv) infection is common among prisoners, relatively few undergo evaluation for treatment. this study reports the prevalence of chronic infection and the genotype distribution among an incarcerated population. hcv antibody testing was provided to adults entering pennsylvania prisons; confirmatory and genotype testing were offered to those eligible for treatment. antibody prevalence among 101,727 individuals was 18.1%. among 7,633 individuals who underwent confirmatory testi ...201626672118
liver transplantation for hepatitis b in the united states.to evaluate the impact of hepatitis b virus (hbv) on us health care system, we reviewed the organ procurement and transplantation (optn, formerly unos) hbv database.200516387118
an assessment of hiv-infected patients dying in care for deceased organ donation in a united states urban center.organ transplantation is an acceptable option for human immunodeficiency virus (hiv)-infected patients with end-stage kidney or liver disease. with worse outcomes on the waitlist, hiv-infected patients may actually be disproportionately affected by the organ shortage in the united states. one potential solution is the use of hiv-infected deceased donors (hivdd), recently legalized by the hiv organ policy equity (hope) act. this is the first analysis of patient-specific data from potential hivdd, ...201525976241
identification and linkage to care of hcv-infected persons in five health centers - philadelphia, pennsylvania, 2012-2014.approximately three million persons in the united states are infected with hepatitis c virus (hcv), a blood-borne pathogen that is an increasing cause of liver disease and mortality in the united states. treatments for hcv are curative, of short duration, and have few associated side effects, increasing the importance of identifying hcv-infected persons. many persons with hcv infection were infected decades ago, before implementation of prevention measures and most are unaware of their infection ...201525950252
dual-routine hcv/hiv testing: seroprevalence and linkage to care in four community health centers in philadelphia, pennsylvania.despite common risk factors, screening for hepatitis c virus (hcv) and hiv at the same time as part of routine medical care (dual-routine hcv/hiv testing) is not commonly implemented in the united states. this study examined improvements in feasibility of implementation, screening increase, and linkage to care when a dual-routine hcv/hiv testing model was integrated into routine primary care.201726862229
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