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the diversity of vaca and caga genes of helicobacter pylori in east asia.it has been reported that helicobacter pylori infection with the type i strain, which expresses the vaca and caga antigens, is associated with duodenal ulcer. we examined the diversity of vaca and caga genes in 143 isolates obtained from patients with duodenal ulcer or chronic gastritis in east asia (two different areas of japan, fukui and okinawa, and also in hangzhou, china) by polymerase chain reaction (pcr) and sequence analysis. diversities of caga and vaca genes were detected in east asia. ...200414734191
helicobacter pylori infection in two areas in japan with different risks for gastric cancer.we evaluated the relationship between helicobacter pylori and various factors associated with gastric cancer in two areas in japan with different risks for mortality due to gastric cancer.200415298598
clinical relevance of cage gene from helicobacter pylori strains in japan.it has been reported that h. pylori-containing cage was associated with duodenal ulcer. the aims of the present study were to clarify the association between the cage gene and clinical outcome and to analyze the relationship between the cage gene and two other virulence factors--caga and vaca--in two areas in japan (fukui and okinawa) where the prevalence of duodenal ulcer and gastric cancer risk are quite different. eighty of 81 isolates possessed the cage gene, and all isolates possessed the c ...200211911357
relationship between the diversity of the caga gene of helicobacter pylori and gastric cancer in okinawa, japan.helicobacter pylori caga protein is considered to be one of the virulence factors associated with gastric cancer. caga is injected into gastric epithelial cells, undergoes tyrosine phosphorylation, and binds to src homology 2 domain-containing protein-tyrosine phosphatase (shp-2). two major subtypes of caga have been observed in the shp-2-binding site, the western and east asian types. the east asian-type caga binds to shp-2 more strongly than the western-type caga. the diversity of caga, which ...200616933004
profile of helicobacter pylori cytotoxin derived from two areas of japan with different prevalence of atrophic gastritis.to clarify the roles of helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in fukui and okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied.19969038660
Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, southwestern island of Japan.The incidence of gastric cancer in Okinawa is the lowest in Japan. Some previous reports using small number of strains suggest that the high prevalence of Helicobacter pylori with Western-type cagA in Okinawa compared with other areas in Japan might contribute to the low incidence of gastric cancer. It has still not been confirmed why the prevalence of Western-type cagA strains is high in Okinawa. We examined the association between the virulence factors of H. pylori and gastroduodenal diseases ...201122189111
j-western forms of helicobacter pylori caga constitute a distinct phylogenetic group with a widespread geographic distribution.chronic infection with helicobacter pylori strains expressing the bacterial oncoprotein caga confers an increased risk of gastric cancer. while much is known about the ancestry and molecular evolution of western, east asian, and amerindian caga sequences, relatively little is understood about a fourth group, known as "j-western," which has been detected mainly in strains from okinawa, japan. we show here that j-western caga sequences have a more widespread global distribution than previously rec ...201222247512
helicobacter pylori caga 12-bp insertion can be a marker for duodenal ulcer in okinawa, japan.helicobacter pylori caga can be classified into mainly two types (east-asian-type and western-type caga) according to the repeat regions located in the 3' region. recent studies showed that the western-type caga in strains from okinawa, japan formed a different cluster (j-western-type caga subtype). it has also been reported that j-western-type caga possesses a 12-bp insertion located in the 5' region of caga sequence.201323190390
helicobacter pylori infection in japan.the prevalence of helicobacter pylori infection is gradually decreasing in japan. on the main island of japan, nearly all h. pylori isolates possess caga and vaca with strong virulence. however, less virulent h. pylori strains are frequently found in okinawa where cases of gastric cancer are the lowest in japan. eradication therapy for peptic ulcer, idiopathic thrombocytopenic purpura, gastric mucosa-associated lymphoid tissue lymphoma and early gastric cancer after endoscopic resection has been ...201323265147
sequence analysis and clinical significance of the icea gene from helicobacter pylori strains in japan.the helicobacter pylori icea gene was recently identified as a genetic marker for the development of peptic ulcer in a western population. to assess the significance of icea subtypes of h. pylori in relation to peptic ulcer, 140 japanese clinical isolates (88 from fukui and 52 from okinawa) were characterized. sequence analysis of the icea1 gene from 25 representative japanese strains was also carried out to identify the differences in icea between the ulcer group and the gastritis group. the ic ...200010655332
[detection of prehistoric human migration by helicobacter pylori].helicobacter pylori is not only a well known gastroduodenal pathogen but also a useful marker for tracing prehistoric footprints of human populations. because h. pylori transmits mainly through vertical infection and has been carried in our stomach from generation to generation, its geneology well reflects that of human. we investigated genes of h. pylori from a wide variety of ethnicity and predicted the journey of ancient people after the departure from the african continent in 100 to 50 thous ...201323967665
the association between objective tongue color and endoscopic findings: results from the kyushu and okinawa population study (kops).the relation between tongue color and gastroesophageal disease is unclear. this study was done to investigate the associations between tongue color (tc), endoscopic findings, helicobacter.pylori infection status, and serological atrophic gastritis (sag).201526474972
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