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differences in clinical profiles of patients with protobothrops mucrosquamatus and viridovipera stejnegeri envenoming in taiwan.envenoming by protobothrops mucrosquamatus and viridovipera stejnegeri accounts for the majority of venomous snakebites in taiwan. we conducted a retrospective study to systematically examine the clinical manifestations and responses to antivenom therapy after p. mucrosquamatus and v. stejnegeri envenoming. information on demographic characteristics, treatments, and systemic/local complications were abstracted from medical charts between 1991 and 2006. one hundred forty-nine patients with p. muc ...200919141835
molecular cloning and deduced primary structures of acidic and basic phospholipases a2 from the venom of deinagkistrodon acutus.this paper presents the nucleotide sequences of the cdnas encoding three acidic phospholipases a2 and one basic phospholipase a2 from deinagkistrodon acutus venom. the deduced primary structure of the basic enzyme is closest to that of the basic neurotoxic enzyme from trimeresurus mucrosquamatus venom, while the acidic phospholipases from d. acutus have highest sequence similarity to that from agkistrodon halys pallas. the phylogeny of this monotypic species is discussed.19968931260
antivenom therapy for crotaline snakebites: has the poison control center provided effective guidelines?crotaline snakebites (protobothrops mucrosquamatus and trimeresurus stejnegeri) are a common medical emergency in taiwan that can be effectively treated by a bivalent f(ab)2 antivenom. we investigated the differences in the clinical outcomes of patients who received different therapeutic regimens of antivenom in a medical center where clinical toxicologists followed the poison control center (pcc) guidelines (medical group) and surgeons did not (surgical group). the medical records of inpatients ...200718194914
taiwan's venomous snakebite: epidemiological, evolution and geographic differences.located at the juncture of tropical and subtropical regions, taiwan has a warm and humid climate with abundant precipitation and food, which coupled with the island's diverse vegetation and landscape, makes it a suitable environment for many snake species. among these, naja atra, bungarus multicinctus, deinagkistrodon acutus, trimeresurus mucrosquamatus, trimeresurus stejnegeri, daboia russelii siamensis are the 6 principal venomous species, and have caused significant injuries and death over th ...200414964809
differential expression and geographic variation of the venom phospholipases a2 of calloselasma rhodostoma and trimeresurus mucrosquamatus.to investigate the geographic variations in venoms of two medically important pitvipers, we have purified and characterized the phospholipases a2 (pla2s) from the pooled venoms of calloselasma rhodostoma from malaysia, thailand, indonesia, and vietnam, as well as the individual venom of trimeresurus mucrosquamatus collected from both north and south taiwan. enzymatic and pharmacological activities of the purified pla2s were also investigated. the complete amino acid sequences of the purified pla ...200111370849
the relationship between the dose of taiwan cobra (naja atra) and taiwan habu (trimeresurus mucrosquamatus) venom and time of death in mice. 195613357745
management of poisonous snake bites in southern taiwan.snake bite envenomation is not uncommon in taiwan. this study focuses on the pattern of poisonous snake bites and their management in southern taiwan over a 5-year period. the case histories of 37 patients with poisonous snake bites admitted to the kaohsiung medical university hospital between june 2001 and july 2005 were analyzed retrospectively. three patients, bitten by unknown species of venomous snakes, were excluded from this study. the frequency of snakebites from each species of snake, t ...200718055297
isolation of a venom factor devoid of proteolytic activity from taiwan habu (trimeresurus mucrosquamatus): n-terminal sequence homology and no functional similarity to factors ix/x-binding proteins and botrocetin.one novel venom factor was isolated and purified from the venom of taiwan habu (trimeresurus mucrosquamatus) using two consecutive anion-exchange and gel-filtration chromatographies followed by cation-exchange hplc. further characterization of the purified protein indicated that it lacks the proteolytic activity toward fibrinogen molecules, suggesting that this protein factor does not belong to the familes of metalloproteinases and thrombin-like serine proteases commonly found in the crude venom ...19968968958
bacterial infection in association with snakebite: a-á10-year experience in a northern taiwan medical center.background: microbiological data of secondary wound infections following snakebites is rarely reported in taiwan. the objective of this study was to assess the secondary wound infection after venomous snakebites. methods: we conducted a 10-year retrospective survey on patients admitted for venomous snakebites and microbiological data of wound cultures at a medical center in northern taiwan. results: between april 2001 and april 2010, 231 patients who experienced snakebites were included. male pr ...201121700517
snake venomics and antivenomics of protobothrops mucrosquamatus and viridovipera stejnegeri from taiwan: keys to understand the variable immune response in horses.the proteomes of the venoms of the snakes viridovipera stejnegeri and protobothrops mucrosquamatus from taiwan were characterized by n-terminal sequencing, maldi-tof mass fingerprinting, and collision-induced dissociation tandem mass spectrometry of in-gel generated tryptic peptides. proteins belonging to the following toxin classes were identified: metalloproteinase, phospholipase a(2) (pla(2)), serine proteinase, c-type lectin-like, crisp, l-amino acid oxidase, disintegrin, and peptides (vasoa ...201222906718
treatment of poisonous snakebites in northern taiwan.we evaluated the epidemiology and outcomes of snakebites in northern taiwan, and the effect of local antivenom injection to speed neutralization and reduce the spread of venom.200010770028
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