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prevalence and epidemiological traits of hiv infections in populations with high-risk behaviours as revealed by genetic analysis of hbv.the prevalence and epidemiological traits of human immunodeficiency virus (hiv)/hepatitis b virus (hbv) infections in high-risk populations (hrps) remained unclarified in japan. we determined the prevalence of hiv, hbv and treponema pallidum (tp) and the viral genotypes in hrps who attended primary sexually transmitted infection (sti) clinics in osaka province during 2006-2011. of 7898 specimens, 133 (1·7%) were hiv positive, which was significantly higher than the figures reported by japanese r ...201323347648
identification of novel recombinant forms of hepatitis b virus generated from genotypes ae and g in hiv-1-positive japanese men who have sex with men.the rare hepatitis b virus (hbv) genotype g (hbv/g) coinfects hiv-1-positive individuals along with hbv/a and generates recombinants. however, the circulation of hbv a/g recombinants remains poorly understood. this molecular epidemiologic study examined hbv a/g recombinants in japanese hiv-1-positive men who have sex with men (msm). initially, blood specimens submitted for confirmatory tests of hiv infection in osaka and tokyo, japan, from 2006 to 2013 were examined for hiv-1, and hiv-1-positive ...201525825936
prospective study on the risk of hepatocellular carcinoma among hepatitis c virus-positive blood donors focusing on demographic factors, alanine aminotransferase level at donation and interaction with hepatitis b virus.the risk for hepatocellular carcinoma (hcc) among asymptomatic hepatitis c virus (hcv) carriers is not well understood. a community-based prospective study was conducted for over 8 years by record linkage to the osaka cancer registry. the subjects were 1,927 individuals who were positive for anti-hcv through screening for second-generation hcv antibody (passive hemagglutination assay: >or= 2(12)) in voluntary blood donation. the risk factors for hcc and interaction between hcv and hepatitis b vi ...200415386355
homeless patients with hepatocellular carcinoma in osaka city, japan.although the number of homeless persons is increasing worldwide, studies delineating the health status of these persons according to various medical perspectives, including hepatology, are limited. however, such studies are important for understanding the pathogenesis of diseases and their prevention.199910370675
case-control study of hepatocellular carcinoma among koreans living in osaka, japan.mortality rates from liver cancer among koreans living in osaka are 2-3 times higher than those among japanese. our previous study revealed that chronic hepatitis b virus (hbv) infection and excessive alcohol drinking are two major risk factors for hepatocellular carcinoma (hcc) among koreans in osaka, although more than 70% of the hcc cases were negative for hepatitis b surface antigen (hbsag). using a recently developed immunoassay for detecting serum hepatitis c virus antibody (hcv-ab), the r ...19948071108
hepatitis b virus and alcoholic liver damage in the airin district. (osaka's skid row area).healthy adults and non-liver disease patients in the airin district gave a positivity rate for hbs antigen of approximately 2%, which is not so much different from the average of the entire japanese population. in this district, the positive rate of hbs antigen 5% (11 out of 244) in chronic liver disease is much lower than that (31%) of control group patients at osaka city university hospital (o.c.u.h.). however the positive rate of anti-hbs antibody in this district is 46% which is extremely hi ...19806155305
time trends of the prevalences of hepatitis b e antigen positives among hepatitis b virus carriers in japan.in order to examine time trends of the prevalences of hbeag positives among hbv carriers in japan, we analysed data on hbeag of hbsag positive voluntary blood donors (23,560 males, and 8659 females) at the osaka red cross blood centre between january 1977 and march 1984. age-specific prevalences of hbeag positives decreased year by year for both sexes, especially for those in their teens and twenties. the prevalences of hbeag positives decreased with age, but at any given age it was lower for th ...19873440668
[a serological survey and histopathological comparison of hbv-associated liver diseases in southern part of korea and west japan].a high mortality rate due to hepatocellular carcinoma (hcc) associated with a high prevalence of hepatitis b virus (hbv) infection is a big problem in all asian countries, including korea and japan. in this study, a serological survey and a histopathological comparison of hbv-associated liver diseases in korea and in the western part of japan were performed. in- and outpatients of kosin university hospital (kuh) and of uoeh hospital were analysed serologically, and the hbsag-positive rate among ...19892549603
a case-control study of hepatocellular carcinoma in osaka, japan.a case-control study was undertaken to evaluate the roles of hepatitis b virus (hbv), blood transfusion, alcohol drinking and cigarette smoking in the etiology of hepatocellular carcinoma (hcc) in osaka, japan. a total of 229 cases and 266 hospital controls were included in our study. the relative risks of hcc obtained after adjustment for age, sex and other important variables were 14.3 (95% confidence interval (ci): 5.7-36.3) for hbsag positives, 4.3 (95% ci: 1.9-9.6) for blood recipients and ...19902154409
mass protection program of perinatal hepatitis b virus infection in japan and impact of an optional booster vaccination on its efficacy.we assessed the efficacy of a government-sponsored mass protection program in osaka, japan, for perinatal hbv infection in infants born to hbeag positive hbv carrier mothers. we also evaluated the impact of optional follow-up procedures in such infants, including an evaluation of anti-hbs response and a booster dose of hbv vaccine for poor responders. the results demonstrated that this mass protection program protected 94.4% of the infants from perinatal hbv infection in the osaka area. however, ...19911785327
risk factors for intrahepatic cholangiocarcinoma: a possible role of hepatitis b virus.there are several established risk factors for intrahepatic cholangiocarcinoma (icc), namely primary sclerosing cholangitis, fibropolycystic liver disease, parasitic infection, intrahepatic biliary stones and chemical carcinogen exposure. however, the majority of patients with icc do not have any of these risk factors. therefore, identification of other risk factors is warranted for the prevention and early detection of icc. we evaluated the risk factors for icc in a large-scale cohort study in ...201020002305
primary liver cancer incidence-rates related to hepatitis-c virus infection: a correlational study in osaka, japan.osaka, japan, has one of the highest, primary liver cancer (plc) incidence-rates in the world, although hepatitis-b virus (hbv) is not endemic. this paper addresses the question of whether the plc-incidence variation within osaka prefecture is due to differences in the prevalence of hepatitis-c virus (hcv) infection. the screening data of antibody to hcv (anti-hcv) and of hepatitis-b virus antigen (hbsag) in 111,069 male blood-donors, and the incidence data of male plc obtained from the osaka ca ...19947510133
[liver cancer and life style--drinking habits and smoking habits].japan is one of the endemic area of liver cancer in the world with its incidence rate of more than 30 per 100,000 population for males in osaka. it is well known that hepatitis b virus is closely related with hepatocellular carcinoma, however, its prevalence is moderately high (2-3%) in japan. the relationship between drinking and liver cancer is examined by 3 different type of studies. first, more than 13,000 male alcoholics were followed for 9.9 years in average. their incidence rate of liver ...19902313879
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