the diversity of vaca and caga genes of helicobacter pylori in east has been reported that helicobacter pylori infection with the type i strain, which expresses the vaca and caga antigens, is associated with duodenal ulcer. we examined the diversity of vaca and caga genes in 143 isolates obtained from patients with duodenal ulcer or chronic gastritis in east asia (two different areas of japan, fukui and okinawa, and also in hangzhou, china) by polymerase chain reaction (pcr) and sequence analysis. diversities of caga and vaca genes were detected in east asia. ...200414734191
clinical relevance of cage gene from helicobacter pylori strains in has been reported that h. pylori-containing cage was associated with duodenal ulcer. the aims of the present study were to clarify the association between the cage gene and clinical outcome and to analyze the relationship between the cage gene and two other virulence factors--caga and vaca--in two areas in japan (fukui and okinawa) where the prevalence of duodenal ulcer and gastric cancer risk are quite different. eighty of 81 isolates possessed the cage gene, and all isolates possessed the c ...200211911357
sequence analysis and clinical significance of the icea gene from helicobacter pylori strains in japan.the helicobacter pylori icea gene was recently identified as a genetic marker for the development of peptic ulcer in a western population. to assess the significance of icea subtypes of h. pylori in relation to peptic ulcer, 140 japanese clinical isolates (88 from fukui and 52 from okinawa) were characterized. sequence analysis of the icea1 gene from 25 representative japanese strains was also carried out to identify the differences in icea between the ulcer group and the gastritis group. the ic ...200010655332
an updated report on the trends in cancer incidence and mortality in japan, 1958-2013.the analysis of cancer trends in japan requires periodic updating. herein, we present a comprehensive report on the trends in cancer incidence and mortality in japan using recent population-based data. national cancer mortality data between 1958 and 2013 were obtained from published vital statistics. cancer incidence data between 1985 and 2010 were obtained from high-quality population-based cancer registries of three prefectures (yamagata, fukui and nagasaki). joinpoint regression analysis was ...201525637502
profile of helicobacter pylori cytotoxin derived from two areas of japan with different prevalence of atrophic clarify the roles of helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in fukui and okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied.19969038660
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