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classic type of kaposi's sarcoma and human herpesvirus 8 infection in xinjiang, china.we report 17 cases of the classic type of kaposi's sarcoma in xinjiang, which is located in the north-western area of china surrounded by mongolia in the east, russia in the north and kazakhstan in the west. fifteen of the patients were of the uygur people. all patients were male and did not have acquired immunodeficiency syndrome. most of the lesions were found in the lower and/or upper extremities, with 16 patients showing multiple lesions. immunohistochemical examination of the lesions reveal ...200111844050
human herpesvirus 8: serovprevalence and correlates in tumor patients from xinjiang, china.human herpesvirus 8 (hhv-8), also known as kaposi's sarcoma-associated herpesvirus, is etiologically associated with kaposi's sarcoma and other lymphoproliferative diseases. although hhv-8 prevalence exhibits considerable variation in different geographic regions and populations, the incidence of kaposi's sarcoma appear to increase in areas with a high prevalence rate. in this study, an enzyme-linked immunosorbent assay based on mixed antigens of hhv-8 orf(73), orf(65), and k8.1 in the antigenic ...200717177299
[seroepidemiology of kaposi' s sarcoma-associated herpesvirus in drug users in xinjiang, china]. 200919731543
[research on co-infections of hiv and human herpesvirus-8 among the uygur high-risk groups in a city, xinjiang].to research the co-infections of hiv and human herpesvirus 8 (hhv8) in uygur high-risk groups of hiv infection in a city xinjiang.200920137516
human herpesvirus-8 in northwestern china: epidemiology and characterization among blood donors.human herpes virus 8 (hhv-8) is the etiologic agent associated with development of classical, aids-related, iatrogenic, and endemic kaposi's sarcoma (ks). several studies provide strong evidence that hhv-8 can be transmitted by blood transfusion. we evaluated the seroprevalence and potential risk factors of hhv-8 infection in blood donors in one region. we surveyed hhv-8 infection among 4461 blood donors in xinjiang, china, a unique endemic area for hhv-8 and ks.201020236530
seroprevalence of kaposi's sarcoma-associated herpesvirus and risk factors in xinjiang, china.xinjiang, china is an endemic area for kaposi's sarcoma (ks) but the seroprevalence of kaposi's sarcoma-associated herpesvirus (kshv) and risk factors remain undefined. in this study, antibodies to one kshv latent protein (orf73) and two kshv lytic proteins (orf65 and orf-k8.1) were examined in 2,228 subjects from the general population and 37 subjects infected with hiv-1 in xinjiang, and 560 subjects from the general population in hubei, a low ks incidence region. the serostatus of a serum samp ...200919551832
[antibody to human herpesvirus type-8 in the general populations of xinjiang autonomous region(a.r.)].kaposi 's sarcoma (ks) does not rarely occur in xinjiang a. r. much of the evidence show that human herpes virus-8 (hhv-8) is associated with ks, and the different incidence of classic ks among different countries reflects the different prevalence in general populations. the aim of this study was to know whether the prevalence of hhv-8 is higher in general populations of xinjiang than the other places of the country.200011503024
establishment of an elisa to detect kaposi's sarcoma-associated herpesvirus using recombinant orf73.kaposi's sarcoma-associated herpesvirus (kshv) is causally related to kaposi's sarcoma (ks), primary effusion lymphoma (pel) and a proportion of cases of multicentric castleman's disease (mcd). the orf73 protein was cloned into pqe80l-orf73 and expressed in e.coli and purified. the expressed recombinant orf73 was identified by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (sds-page). a protein of about 27 kda was expressed as expected. western blotting showed that the purified recombi ...201020960290
northwestern china: a place to learn more on oesophageal cancer. part one: behavioural and environmental risk factors.oesophageal squamous cell carcinoma (oscc) remains a public health problem in many countries, especially in emerging and developing countries. epidemiology of oscc is characterized by marked differences in prevalence between countries/regions/ethnical groups. the highest incidence in the world is reached by populations living in specific areas of northwestern xinjiang, china where age-adjusted mortality may reach 150 of 100 000. in fact, there are also marked differences among the various geogra ...201020520561
virological and molecular characterization of kaposi's sarcoma-associated herpesvirus strains from xinjiang, china.kaposi's sarcoma (ks) is a highly and abnormally vascularized tumor-like lesion affecting the skin. ks-associated herpesvirus (kshv/hhv-8) is etiologically linked to all epidemiological forms of ks. however, clinical phenotypes show considerable discrepancy, indicating the presence of virological and molecular characteristics of kshv that influence its pathogenesis. we investigated the molecular virological features of kshv strains from xinjiang, where kshv infection is endemic and there is a hi ...201121537910
Seroprevalence and risk factors of Kaposi's sarcoma-associated herpesvirus infection among the general Uygur population from south and north region of Xinjiang, China.ABSTRACT: BACKGROUND: Kaposi sarcoma (KS) is a complex multifocal neoplasm and is the major cause of death for about 50% of acquired immunodeficiency syndrome (AIDS) patients. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus with a causal role in the development of all types of KS. KS is prevalent among the Uygur people in Xinjiang, especially in south area. Here we carried out a cross-sectional study among 1534 general Uygur individuals from south and north region of Xinji ...201122168313
seroprevalence of kaposi's sarcoma-associated herpesvirus among hiv-infected uygurs in xinjiang, china.kaposi's sarcoma-associated herpesvirus (kshv) is the etiological agent of kaposi's sarcoma (ks), which primarily affects human immunodeficiency virus (hiv)-infected adults with advanced immunodeficiency. xinjiang province in china is an endemic area for kaposi's sarcoma (ks), however, currently, only limited prevalence data for kshv infection in hiv-infected individuals living in this endemic area is available. a cross-sectional study of 86 hiv positive participants was conducted in xinjiang, c ...201728252177
was kaposi's sarcoma-associated herpesvirus introduced into china via the ancient silk road? an evolutionary perspective.kaposi's sarcoma-associated herpesvirus (kshv) has become widely dispersed worldwide since it was first reported in 1994, but the seroprevalence of kshv varies geographically. kshv is relatively ubiquitous in mediterranean areas and the xinjiang uygur autonomous region, china. the origin of kshv has long been puzzling. in the present study, we collected and analysed 154 kshv orf-k1 sequences obtained from samples originating from xinjiang, italy, greece, iran and southern siberia using bayesian ...201728687922
genotypic analysis of kaposi's sarcoma-associated herpesvirus from patients with kaposi's sarcoma in xinjiang, china.kaposi's sarcoma-associated herpesvirus (kshv) is the causal agent of all forms of kaposi's sarcoma (ks), including aids-ks, endemic ks, classic ks and iatrogenic ks. based on open reading frame (orf) k1 sequence analysis, kshv has been classified into seven major molecular subtypes (a, b, c, d, e, f and z). the distribution of kshv strains varies according to geography and ethnicity. xinjiang is a unique region where the seroprevalence of kshv is significantly higher than other parts of china. ...201425431948
high prevalence of early childhood infection by kaposi's sarcoma-associated herpesvirus in a minority population in china.in china, kshv seroprevalence varies considerably among different regions and ethnicities. but in xinjiang province, located in the northwestern china, there is a very high seroprevalence of kshv in adults of kazak and ughur ethnicities. however, kshv prevalence in children and the risk factors associated with the acquisition of infection are currently not known. the aim of this study was to investigate the prevalence of kshv infection and identify associated socioeconomic or behavioural risk fa ...201423992104
prevalence of kaposi's sarcoma-associated herpesvirus in uygur and han populations from the urumqi and kashgar regions of xinjiang, china.kaposi's sarcoma-associated herpesvirus (kshv) is the infectious etiologic agent associated with kaposi's sarcoma (ks), primary effusion lymphoma, and multicentric castleman disease. it has been shown that high kshv prevalence and high incidence of both classic ks and aidsassociated ks are found mostly among people of uygur ethnicity in xinjiang, while people of han ethnicity in xinjiang have a higher kshv seroprevalence than those of other han populations in mainland china. however, it is still ...201729116591
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