| dengue virus type 4 phylogenetics in brazil 2011: looking beyond the veil. | dengue fever and dengue hemorrhagic fever are diseases affecting approximately 100 million people/year and are a major concern in developing countries. in the present study, the phylogenetic relationship of six strains of the first autochthonous cases of denv-4 infection occurred in sao paulo state, parana state and rio grande do sul state, brazil, 2011 were studied. nucleotide sequences of the envelope gene were determined and compared with sequences representative of the genotypes i, ii, iii a ... | 2011 | 22216365 |
| genetic variation in the 3' untranslated region of dengue virus serotype 3 strains isolated from mosquitoes and humans in brazil. | dengue, a mosquito-borne viral infection caused by one of the four dengue virus (denv) serotypes (denv-1 to 4), replicate alternately on the mosquito vector and human host and are responsible for infections throughout tropical and subtropical regions of the world. in brazil, the disease has become a major public health problem and the introduction of denv-3 in 2000 in rio de janeiro (rj) was associated with severe dengue epidemics. the potential emergence of strains associated with severe diseas ... | 2013 | 23282086 |
| phylogeography of dengue virus serotype 4, brazil, 2010-2011. | dengue virus serotype 4 (denv-4) reemerged in roraima state, brazil, 28 years after it was last detected in the country in 1982. to study the origin and evolution of this reemergence, full-length sequences were obtained for 16 denv-4 isolates from northern (roraima, amazonas, pará states) and northeastern (bahia state) brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in roraima. spatiotemporal dynamics of denv-4 introductions in brazil were applied t ... | 0 | 23092706 |
| investigation into an outbreak of dengue-like illness in pernambuco, brazil, revealed a cocirculation of zika, chikungunya, and dengue virus type 1. | in april 2015, an outbreak of dengue-like illness occurred in tuparetama, a small city in the northeast region of brazil; this outbreak was characterized by its fast expansion. an investigation was initiated to identify the viral etiologies and advise the health authorities on implementing control measures to contain the outbreak. this is the first report of this outbreak in the northeast, even though a few cases were documented earlier in a neighboring city.plasma samples were obtained from 77 ... | 0 | 27015222 |
| occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in aedes aegypti and aedes albopictus in fortaleza, ceará, brazil. | aedes aegypti and aedes albopictus perform an important role in the transmission of the dengue virus to human populations, particularly in the tropical and subtropical regions of the world. despite a lack of understanding in relation to the maintenance of the dengue virus in nature during interepidemic periods, the vertical transmission of the dengue virus in populations of a. aegypti and a. albopictus appears to be of significance in relation to the urban scenario of fortaleza. | 2012 | 22848479 |
| clinical and virological descriptive study in the 2011 outbreak of dengue in the amazonas, brazil. | dengue is a vector-borne disease in the tropical and subtropical region of the world and is transmitted by the mosquito aedes aegypti. in the state of amazonas, brazil during the 2011 outbreak of dengue all the four dengue virus (denv) serotypes circulating simultaneously were observed. the aim of the study was to describe the clinical epidemiology of dengue in manaus, the capital city of the state of the amazonas, where all the four denv serotypes were co-circulating simultaneously. | 2014 | 24978469 |
| emerging arboviruses and public health challenges in brazil. | environmental modification by anthropogenic actions, disordered urban growth, globalization of international exchange and climate change are some factors that help the emergence and dissemination of human infectious diseases transmitted by vectors. this review discusses the recent entry of three arboviruses in brazil: chikungunya, west nile, and zika virus, focusing on the challenges for the country's public health. the brazilian population is exposed to infections caused by these three arboviru ... | 0 | 27355468 |
| isolation and characterization of mayaro virus from a human in acre, brazil. | mayaro virus (mayv) is widely distributed throughout south america and is the etiologic agent of mayaro fever, an acute febrile illness often presenting with arthralgic manifestations. the true incidence of mayv infection is likely grossly underestimated because the symptomatic presentation is very similar to that of dengue fever and other acute febrile tropical diseases. we report the complete genome sequence of a mayv isolate detected from an acrelândia patient presenting with fever, chills, a ... | 2014 | 25510721 |
| diversity and localization of bacterial endosymbionts from whitefly species collected in brazil. | whiteflies (hemiptera: aleyrodidae) are sap-sucking insect pests, and some cause serious damage in agricultural crops by direct feeding and by transmitting plant viruses. whiteflies maintain close associations with bacterial endosymbionts that can significantly influence their biology. all whitefly species harbor a primary endosymbiont, and a diverse array of secondary endosymbionts. in this study, we surveyed 34 whitefly populations collected from the states of sao paulo, bahia, minas gerais an ... | 2014 | 25259930 |
| dengue virus 2 american-asian genotype identified during the 2006/2007 outbreak in piauí, brazil reveals a caribbean route of introduction and dissemination of dengue virus in brazil. | dengue virus (denv) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. dengue is caused by denv-1, denv- 2, denv-3 and denv-4 which are genetically distant. the species has been subdivided into genotypes based on phylogenetic studies. denv-2, which was isolated from dengue fever patients during an outbreak in piaui, brazil in 2006/2007 was analyzed by sequencing the envelope (e) gene. the results indicated a high simi ... | 2014 | 25127366 |
| laboratory surveillance of dengue in rio grande do sul, brazil, from 2007 to 2013. | according to official records, dengue was introduced in brazil in the 80's; since then several epidemics have occurred. meanwhile, in rio grande do sul (rs, southern brazil) the first autochthonous case occurred only in 2007. | 2014 | 25116186 |
| density of aedes aegypti and aedes albopictus and its association with number of residents and meteorological variables in the home environment of dengue endemic area, são paulo, brazil. | measure the populations of ae. aegypti and ae. albopictus adults according to sex and location inside or outside the residence, estimate ae. aegypti female density per house and per resident, and test the association with abiotic factors. | 2015 | 25890384 |
| maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management. | dengue fever (df) outbreaks present regionally specific epidemiological and clinical characteristics. in certain medium-sized cities (100 000-250 000 inhabitants) of são paulo state, brazil, and after reaching an incidence of 150 cases/100 000 inhabitants ("epidemiological threshold"), clinical diagnosis indicated dengue virus (denv) infection. during this period, other seasonally infectious diseases with symptoms and physical signs mimicking df can simultaneously occur, with the consequential o ... | 2016 | 27593529 |
| accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a denv-4 epidemic. | early diagnosis of dengue infection is important for decision-making and timely implementation of therapeutic measures. although rapid ns1 assays have been used for dengue diagnosis since 2008, their performance in denv-4 cases has not yet been fully assessed. | 2016 | 26822788 |
| fitness cost in field and laboratory aedes aegypti populations associated with resistance to the insecticide temephos. | the continued use of chemical insecticides in the context of the national program of dengue control in brazil has generated a high selective pressure on the natural populations of aedes aegypti, leading to their resistance to these compounds in the field. fitness costs have been described as adaptive consequences of resistance. this study evaluated the biological and reproductive performance of a. aegypti strains and a field population resistant to temephos, the main larvicide used for controlli ... | 2015 | 26715037 |
| assessing positivity and circulating levels of ns1 in samples from a 2012 dengue outbreak in rio de janeiro, brazil. | dengue virus (denv) represents a major threat to public health worldwide. early denv diagnosis should not only detect the infection but also identify patients with a higher likelihood to develop severe cases. previous studies have suggested the potential for ns1 to serve as a viral marker for dengue severity. however, further studies using different sera panels are required to confirm this hypothesis. in this context, we developed a lab-based elisa to detect and quantitate ns1 protein from the f ... | 2014 | 25412084 |
| circulation of different lineages of dengue virus 2, genotype american/asian in brazil: dynamics and molecular and phylogenetic characterization. | the american/asian genotype of dengue virus type 2 (denv-2) was introduced into the americas in the 80's. although there is no data showing when this genotype was first introduced into brazil, it was first detected in brazil in 1990. after which the virus spread throughout the country and major epidemics occurred in 1998, 2007/08 and 2010. in this study we sequenced 12 denv-2 genomes obtained from serum samples of patients with dengue fever residing in são josé do rio preto, são paulo (sjrp/sp), ... | 2013 | 23533624 |
| isolation of saint louis encephalitis virus from a horse with neurological disease in brazil. | st. louis encephalitis virus (slev) is a causative agent of encephalitis in humans in the western hemisphere. slev is a positive-sense rna virus that belongs to the flavivirus genus, which includes west nile encephalitis virus, japanese encephalitis virus, dengue virus and other medically important viruses. recently, we isolated a slev strain from the brain of a horse with neurological signs in the countryside of minas gerais, brazil. the slev isolation was confirmed by reverse-transcription rt- ... | 2013 | 24278489 |
| isolation of dengue virus serotype 4 genotype ii from a patient with high viral load and a mixed th1/th17 inflammatory cytokine profile in south brazil. | we report the isolation and characterization of dengue virus (denv) serotype 4 from a resident of santa fé, state of paraná, south brazil, in march 2013. this patient presented with hemorrhagic manifestations, high viral load and, interestingly, a mixed th1/th17 cytokine profile. | 2016 | 27267473 |
| microbial translocation is associated with extensive immune activation in dengue virus infected patients with severe disease. | severe dengue virus (denv) disease is associated with extensive immune activation, characterized by a cytokine storm. previously, elevated lipopolysaccharide (lps) levels in dengue were found to correlate with clinical disease severity. in the present cross-sectional study we identified markers of microbial translocation and immune activation, which are associated with severe manifestations of denv infection. | 2013 | 23717702 |
| complete genome sequence of a dengue virus serotype 4 strain isolated in roraima, brazil. | dengue is the most important arboviral disease worldwide. we report the complete genome sequence of a dengue virus serotype 4, genotype ii strain isolated in 2010 from a patient with classical dengue fever in boa vista, roraima, brazil. | 0 | 22247521 |