[current aspects of endemic mucocutaneous leishmaniasis in brazil].mucocutaneous leishmaniasis has a large incidence in brazil. biochemical, immunological and biological studies have characterized three disease agents: leishmania mexicana amazonensis, leishmania brasiliensis guyanensis and leishmania brasiliensis brasiliensis; these have distinct geographical distributions. the last one is the most common and is the most difficult to treat. destructive mucosal lesions can occur days, months or years after the cutaneous lesions. the montenegro intradermal test, ...19854066323
american cutaneous leishmaniasis due to leishmania (viannia) guyanensis as an initial clinical presentation of human immunodeficiency virus infection.the authors present the first report of leishmania (viannia) guyanensis (l.(v.) guyanenesis) associated with human immunodeficiency virus (hiv) in a brazilian heterosexual man. it is also the first case of hiv infection associated with american cutaneous leishmaniasis in brazilian western amazonia. the patient had cutaneous and mucous lesions with a negative montenegro skin test. histopathology showed large numbers of amastigotes, even in a lesion which had clinically healed. l.(v.) guyanenesis ...19989643323
sensitivity of the polymerase chain reaction for the diagnosis of cutaneous leishmaniasis due to leishmania (viannia) guyanensis.the sensitivity of the polymerase chain reaction (pcr) in 35 consecutive outpatients with cutaneous leishmaniasis caused by leishmania (viannia) guyanensis was evaluated using, as gold standard, the in vitro isolation of the parasite through culture of aspirates of the cutaneous ulcers. all isolates were identified using electrophoretic enzyme analysis. patients were mainly young males with recent onset disease without prior specific treatment. pcr was performed using dna extracted from fresh fr ...200111412806
american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the t-helper 1 cell response.cutaneous leishmaniasis, leprosy, and tuberculosis are caused by intracellular pathogens whose development depends on impaired cell-mediated immunity. we report an exceptional triple association of american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis in a man with no recognized immunodeficiency. normal immunological assessment of the interferon-gamma pathway does not support the hypothesis of a genetic defect in any of the genes involved in the t helper (th)-1 cytoki ...200312942392
antibody response in patients with cutaneous leishmaniasis infected by leishmania (viannia) braziliensis or leishmania (viannia) guyanensis in brazil.the antibody response against leishmania (leishmania) amazonensis crude antigen was measured through the indirect immunofluorescent assay (ifa) and the immunoenzymatic assay (elisa) in 114 patients with cutaneous leishmaniasis (cl) in brazil. fifty-four patients were infected by leishmania (viannia) braziliensis, and 60 patients had l. (v.) guyanensis infection. patients were comparable by age, sex, disease duration and the montenegro skin test diameter. l. (v.) braziliensis-infected patients sh ...200515589797
delay in diagnosis: trauma- and coinfection-related cutaneous leishmaniasis because of leishmania guyanensis infection.trauma can trigger the onset of some lesions of cutaneous leishmaniasis (cl). in this study, we present the case of a 65-year-old man who developed persistent, ulcerative, nodular lymphangiitis at the site of elbow abrasions from a fall during a trip to northeastern brazil. skin and lymph node biopsy showed tuberculoid granulomatous inflammation and grocott-methamine silver-positive yeast forms consistent with sporothrix and staphylococcus lugdunensis was identified from tissue culture. antibact ...200918494815
leishmania (viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the brazilian amazon highland.cutaneous leishmaniasis caused by leishmania (viannia) guyanensis (cl-lguy) is endemic in the brazilian amazon, differing from l. braziliensis infection in clinical, diagnostic, and therapeutic aspects. t-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of cl-lguy was studied herein. variable lymphoproliferative responses (lprs) to leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. active disease ...200919270278
combining diagnostic procedures for the management of leishmaniasis in areas with high prevalence of leishmania guyanensis.the amazon region corresponds to approximately 40% of the cases of leishmaniasis in brazil. we report a prospective study with 180 patients conducted in a health care unit that diagnoses 10% of the cases of leishmaniasis in the brazilian amazon. the study addresses how a combination of procedures improves diagnosis in areas with high prevalence of leishmania guyanensis.201122281902
genetic diversity and population structure in the leishmania guyanensis vector lutzomyia anduzei (diptera, psychodidae) from the brazilian amazon.lutzomyia (nyssomyia) anduzei has been recognized as a secondary vector of leishmania guyanensis in the brazilian amazon region. since l. anduzei is anthropophilic, co-exists in areas of high leishmaniasis transmission and has been found infected with l. guyanensis, the understanding of the vector population structure and of the process responsible for it is paramount to the vector management and control efforts. in this study we analyzed 74 and 67 sequences of the coi and cytb loci, respectivel ...201525701124
molecular taxonomy of the two leishmania vectors lutzomyia umbratilis and lutzomyia anduzei (diptera: psychodidae) from the brazilian amazon.lutzomyia umbratilis (a probable species complex) is the main vector of leishmania guyanensis in the northern region of brazil. lutzomyia anduzei has been implicated as a secondary vector of this parasite. these species are closely related and exhibit high morphological similarity in the adult stage; therefore, they have been wrongly identified, both in the past and in the present. this shows the need for employing integrated taxonomy.201324021095
targeted gene expression profiling in leishmania braziliensis and leishmania guyanensis parasites isolated from brazilian patients with different antimonial treatment brazil, cutaneous leishmaniasis represents a serious public health problem, and chemotherapy is an important element of the clinical management of this disease. however, treatment efficacy is variable, a phenomenon that might be due to host and parasite (e.g., drug resistance) factors. to better understand the possible contribution of parasite factors to this phenomenon, we characterised 12 leishmania braziliensis (lb) and 25 leishmania guyanensis (lg) isolates collected from patients experie ...201020478409
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