Publications

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human metapneumovirus reinfection among children in thailand determined by elisa using purified soluble fusion protein.human metapneumovirus (hmpv) is a newly discovered paramyxovirus that causes acute respiratory illness. despite apparent near-universal exposure during early childhood, immunity is transient.200818680407
dengue infection in children in ratchaburi, thailand: a cohort study. i. epidemiology of symptomatic acute dengue infection in children, 2006-2009.there is an urgent need to field test dengue vaccines to determine their role in the control of the disease. our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial.201222860141
mesoniviruses are mosquito-specific viruses with extensive geographic distribution and host range.the family mesoniviridae (order nidovirales) comprises of a group of positive-sense, single-stranded rna ([+]ssrna) viruses isolated from mosquitoes.201424884700
plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in ratchaburi cohort, thailand.the plaque reduction neutralization test (prnt) is currently the best and most widely accepted approach to measuring virus-neutralizing and protective antibodies to dengue virus, and in assessing the immunogenicity of a dengue vaccine. however, the correlation between presence of dengue-neutralizing antibody and protection from infection is not absolute.201424620925
evidence to support karyotypic variation of the mosquito, anopheles peditaeniatus in thailand.eight isoline colonies of anopheles peditaeniatus leicester (diptera: culicidae) were established from wild-caught females collected from buffalo-baited traps at 8 localities in thailand. they showed 2 types of x (x(2), x(3)) and 4 types of y (y(2), y(3), y(4), y(5)) chromosomes based on the number and amount of major block(s) of heterochromatin present in the heterochromatic arm, and were tentatively designated as forms b (x(2), x(3), y(2)), c (x(3), y(3)), d (x(3), y(4)) and e (x(2), x(3), y(5 ...021521137
healthcare workers' knowledge and practices regarding expanded program on immunization in kalasin, thailand.primary vaccine failures can occur after high immunization coverage has been achieved. healthcare workers' knowledge and practices are influential factors in preventing vaccine failures. adequate knowledge and practices in the cold chain system are important to keep potency of vaccines and effectiveness of immunization. this cross-sectional study was performed to assess healthcare workers' knowledge and practices regarding an expanded program on immunization and the cold chain system in kalasin, ...021928699
recombinase polymerase amplification assay for rapid diagnostics of dengue infection.over 2.5 billion people are exposed to the risk of contracting dengue fever (df). early diagnosis of df helps to diminish its burden on public health. real-time reverse transcription polymerase amplification assays (rt-pcr) are the standard method for molecular detection of the dengue virus (denv). real-time rt-pcr analysis is not suitable for on-site screening since mobile devices are large, expensive, and complex. in this study, two rt-recombinase polymerase amplification (rt-rpa) assays were ...201526075598
improving dengue virus capture rates in humans and vectors in kamphaeng phet province, thailand, using an enhanced spatiotemporal surveillance strategy.dengue is of public health importance in tropical and sub-tropical regions. dengue virus (denv) transmission dynamics was studied in kamphaeng phet province, thailand, using an enhanced spatiotemporal surveillance of 93 hospitalized subjects with confirmed dengue (initiates) and associated cluster individuals (associates) with entomologic sampling. a total of 438 associates were enrolled from 208 houses with household members with a history of fever, located within a 200-m radius of an initiate ...201525986580
geographical structure of dengue transmission and its determinants in thailand.expansion of dengue has been attributed to urbanization. to test this concept, we examined dengue transmission intensities in thailand. we used the inverse of mean age of dengue haemorrhagic fever (dhf) cases as a surrogate of dengue transmission intensity (or force of infection). the transmission intensity in bangkok decreased rapidly since the mid-1990s, to levels that are currently lower than in other regions. regression analysis revealed that transmission intensity is highest in the northeas ...200717624231
identification of clinical factors associated with severe dengue among thai adults: a prospective study.dengue is the most common mosquito-borne viral disease in humans. recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. however, clinical factors associated with severe dengue in adults have varied widely between studies. we aimed to identify the clinical factors associated with the development of severe dengue according to the world health organization (who)'s 2009 definition.201526468084
dengue virus neutralizing antibody levels associated with protection from infection in thai cluster studies.long-term homologous and temporary heterologous protection from dengue virus (denv) infection may be mediated by neutralizing antibodies. however, neutralizing antibody titers (nts) have not been clearly associated with protection from infection.201425329173
maintaining vaccine delivery following the introduction of the rotavirus and pneumococcal vaccines in thailand.although the substantial burdens of rotavirus and pneumococcal disease have motivated many countries to consider introducing the rotavirus vaccine (rv) and heptavalent pneumococcal conjugate vaccine (pcv-7) to their national immunization programs (epis), these new vaccines could affect the countries' vaccine supply chains (i.e., the series of steps required to get a vaccine from their manufacturers to patients). we developed detailed computational models of the trang province, thailand, vaccine ...201121931805
serological response to the 2009 pandemic influenza a (h1n1) virus for disease diagnosis and estimating the infection rate in thai population.individuals infected with the 2009 pandemic virus a(h1n1) developed serological response which can be measured by hemagglutination-inhibition (hi) and microneutralization (micront) assays.201121283570
dengue hemorrhagic fever in infants: research opportunities ignored.the age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (dhf/dss) in infants under the age of 1 year are reported from bangkok, thailand, and for the first time for ho chi minh city, vietnam; yangon, myanmar; and surabaya, indonesia. the four dengue viruses were isolated from thai infants, all of whom were having a primary dengue infection. progress studying the immunologically distinct infant dhf/dss has been limited; most contemporary research has centered on dhf/ds ...200212498666
dengue hemorrhagic fever, uttaradit, thailand. 014626223
dengue infection in children in ratchaburi, thailand: a cohort study. ii. clinical manifestations.dengue infection is one of the most important mosquito-borne diseases. more data regarding the disease burden and the prevalence of each clinical spectrum among symptomatic infections and the clinical manifestations are needed. this study aims to describe the incidence and clinical manifestations of symptomatic dengue infection in thai children during 2006 through 2008.201222389735
how influenza vaccination policy may affect vaccine logistics.when policymakers make decision about the target populations and timing of influenza vaccination, they may not consider the impact on the vaccine supply chains, which may in turn affect vaccine availability.201222537993
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