| hepatitis c virus rna in saliva of patients with posttransfusion hepatitis and low efficiency of transmission among spouses. | in a prospective study of posttransfusion hepatitis, 14 patients who were diagnosed with posttransfusion hepatitis c were enrolled randomly for the study of hepatitis c virus (hcv) rna in saliva. saliva and serum samples were collected on the same day. spouses of 11 married patients were also tested for anti-c100 and hcv rna. paired serum and saliva samples were tested for hcv rna by a nested polymerase chain reaction (pcr). two primer pairs specific for the non-coding region of hcv were used fo ... | 1992 | 1315367 |
| prevalence of antibodies to hepatitis c virus (anti-hcv) in different populations in taiwan. | the prevalence of antibodies to hepatitis c virus (anti-hcv) was investigated among different populations in taiwan, where anti-hcv was detected in 0.8% (24/2,994) of adult volunteer blood donors, 0.1% (1/1,305) of youngsters and children, 12.5% (8/64) of adult volunteer blood donors with elevated alanine aminotransferase (alt), 36.5% (23/63) of hemodialysis patients, 4.1% (13/318) of male homosexuals, 25.4% (16/63) of cases positive for antibodies to human immunodeficiency virus (anti-hiv), 82. ... | 1991 | 1657545 |
| seroprevalence of anti-hcv among voluntary blood donors in taiwan. | the epidemiologic characteristics of hepatitis c virus (hcv) infection among chinese voluntary blood donors in 18 cities and counties all over the taiwan island were studied. serum specimens of 1,135 randomly selected voluntary blood donors were tested for antibodies to hcv by ortho enzyme-linked immunosorbent assay. a total of 18 donors were found to be positive for anti-hcv with a prevalence of 1.6%. females had a higher prevalence (11/491 = 2.2%) than male (7/644 = 1.1%). the prevalence of an ... | 1991 | 1657546 |
| hepatitis c virus infection in an area hyperendemic for hepatitis b and chronic liver disease: the taiwan experience. | to assess the contribution of hepatitis c virus (hcv) in liver disease in taiwan, antibody to hcv (anti-hcv) was studied by radioimmunoassay in 392 patients with chronic liver disease and in 440 healthy adults and 444 subjects at risk. the anti-hcv prevalence was 0.95% in 420 volunteer blood donors, 90% in 100 hemophiliacs, and 81% in 58 parenteral drug abusers. anti-hcv was present in 6 (7.7%) of 78 hepatitis b surface antigen (hbsag)-positive and 28 (65%) of 43 hbsag-negative patients with chr ... | 1990 | 2169497 |
| molecular cloning of cdna of hepatitis c virus (hcv) genome from a healthy carrier in an aboriginal community in taiwan with high prevalence of hcv infection. | we analyzed hepatitis c virus (hcv) obtained from a healthy hcv carrier in an aboriginal community with high prevalence of hcv infection. by use of random primers and specific oligonucleotide primers, a cdna fragment of putative non-structural 3 (ns3) region of the hcv genome was cloned by reverse transcription-polymerase chain reaction (rt-pcr) using rna extracted from a serum sample of a healthy hcv carrier in taur-yuan village. the nucleotide and deduced amino acid sequences from the 583 nucl ... | 1991 | 1668238 |
| hepatitis c virus infection in pregnant women: detection by different anti-hcv immunoassays and serum hcv-rna. | to assess the seroepidemiology of hepatitis c virus (hcv) infection in pregnant women and explore the correlation between different anti-hcv immunoassays, we investigated 2 independent groups in taipei: 1,687 pregnant women without screening for serum alanine aminotransferase (alt) (group a) and 260 pregnant women with elevated alt activity (> 45 iu/l) screened from 15,978 cases (group b). in group a, 11 women (0.65%) were found to be anti-hcv-positive by first-generation tests and 21 (1.24%) by ... | 1994 | 7513510 |
| a prospective study of posttransfusion hepatitis in taiwan. | in a follow-up study of 6 months or more of two hundred and ninety-six patients who had received blood transfusion, 37 (12.5%) developed acute posttransfusion hepatitis. patients with posttransfusion hepatitis had significantly higher donor numbers and transfusion amounts than patients without hepatitis. frequency was not related to the age, sex or hepatitis b carriage of recipients. there were no cases of fulminant hepatitis. of 37 patients with hepatitis, 36 were diagnosed as non-a, non-b hepa ... | 1991 | 1655869 |
| association between hepatitis c virus antibodies and hepatocellular carcinoma in taiwan. | in order to assess the association between antibodies to hepatitis c virus (anti-hcv) and hepatocellular carcinoma (hcc), as well as the interaction of anti-hcv with other hcc risk factors in taiwan, a total of 127 pairs of newly diagnosed hcc patients and healthy community controls were studied. case-control pairs were individually matched for age (+/- 3 years), sex, residence, and ethnicity. serum samples from study subjects were examined for anti-hcv by enzyme immunoassays as well as hepatiti ... | 1991 | 1655259 |
| hepatitis c virus antibody in hepatocellular carcinoma in taiwan. | the prevalence of antibody to hepatitis c virus (anti-hcv) was investigated in patients with hepatocellular carcinoma (hcc), and correlated with the clinical features. anti-hcv was detected in 129 histology or aspiration cytology proven hcc patients and 54 healthy controls. anti-hcv was examined by the hcv eia (abbott laboratories). all healthy controls were anti-hcv-negative. nineteen of 81 (23.5%) hepatitis b surface antigen (hbsag)-positive hcc patients were positive for anti-hcv. anti-hcv wa ... | 1991 | 1653308 |
| isolation of a complementary dna fragment of hepatitis c virus in taiwan revealed significant sequence variations compared with other isolates. | to clone and characterize hepatitis c virus strains present in taiwan, rna was extracted from liver tissue collected from a patient during the acute phase of posttransfusion non-a, non-b hepatitis. rna was then subjected to complementary dna synthesis and the polymerase chain reaction, using primers derived from the original nucleotide sequence of the united states hepatitis c virus strain. a complementary dna clone, hcv-t3, containing 552 base pairs of hepatitis c virus complementary dna sequen ... | 1991 | 1648541 |
| epidemiology of hepatitis c--more lessons to be learnt. | | 1992 | 1385324 |
| relationship between fatty liver, alanine aminotransferase, hbsag and hepatitis c virus. | a community health survey of 923 residents aged 30 years or more was performed in putai township of taiwan. to elucidate the relationships between hepatitis c virus (hcv) and surrogate tests for non-a, non-b hepatitis in hyperendemic areas of hepatitis b virus (hbv) serum levels of alanine aminotransferase (alt), triglycerides, cholesterol, hepatitis b surface antigen (hbsag) and antibody to hcv (anti-hcv) were examined. glucose tolerance tests and the history of diabetes treatment were used to ... | 1992 | 1382655 |
| evaluation of serum alanine transaminase as a surrogate for hepatitis c virus screening. | | 1992 | 1318893 |
| anti-hcv antibody in chinese cirrhotic patients with or without hepatocellular carcinoma: relation to multitransfusion. | to investigate the positive rates of antibodies to hepatitis c virus (anti-hcv) in chinese cirrhotic patients with or without hepatocellular carcinoma and to evaluate the influence of blood transfusion on the prevalence of anti-hcv in such patients, a longitudinal study in 30 cirrhotic patients (17 combined with hepatocellular carcinoma) was carried out. five patients (16.7%) were anti-hcv positive before transfusion. the positive rate of anti-hcv in hbsag-positive patients and hbsag-negative pa ... | 1992 | 1315166 |
| quantitative branched dna assay and genotyping for hepatitis c virus rna in chinese patients with acute and chronic hepatitis c. | to determine the value of a quantitative branched dna (bdna) assay for detection of hepatitis c virus (hcv) rna, 309 serum specimens were collected from 100 patients with acute or chronic hepatitis c for detection of hcv rna by bdna assay and reverse transcription-polymerase chain reaction (rt-pcr) assay. there were 256 samples positive by rt-pcr; 199 (78%) were also positive by bdna assay. all but 1 of the remaining 53 samples negative by rt-pcr were also negative by bdna assay. combination of ... | 1995 | 7844386 |
| genotypes of hepatitis c virus in chronic liver disease in taiwan. | the genotypes of hepatitis c virus (hcv) infection in 81 patients with liver cirrhosis (lc) or hepatocellular carcinoma (hcc) were investigated by the polymerase chain reaction using type-specific primers. all the patients were positive for hcv rna in the serum. forty-two patients had lc with hcc, while the remaining 39 patients had lc without hcc. genotype ii was detected in 47 samples (58.0%), type iii in 6 samples (7.4%), and type iv in 4 (6.2%). no evidence of genotype i was found. mixed inf ... | 1994 | 7852966 |
| the taiwanese hepatitis c virus genome: sequence determination and mapping the 5' termini of viral genomic and antigenomic rna. | the complete nucleotide sequence of hepatitis c virus (hcv) cloned from the liver tissue of a taiwanese patient with post-transfusion type c hepatitis was determined. the 5' end of hcv genomic rna was located 341 nucleotides upstream from the initiation codon for the viral polyprotein open reading frame. the 5' end of the viral antigenomic rna was shown to have 13 consecutive as. thus the 3' terminus of the viral genome is a stretch of u which ends about 50 nucleotides downstream from the stop c ... | 1992 | 1314449 |
| the prevalence of hepatitis c virus antibodies in patients treated with continuous ambulatory peritoneal dialysis. | to assess the prevalence of anti-hcv (hepatitis c virus antibodies) in continuous ambulatory peritoneal dialysis (capd) patients and staff members. | 1992 | 1311963 |
| high prevalence of hepatitis c virus infection in aborigines in taiwan. | in taiwan, the epidemiological status of hcv infection is similar to those observed in other areas of the world, with 1.0% prevalence among adult volunteer blood donors and high prevalences among the high risk groups, by the detection of anti-hcv with synthetic peptide antigens. however, unusually high prevalences, 35.1%, 15.8% and 14.2%, were observed among adult populations in three of the five aboriginal communities. no difference in sex specificity was noted. in 37 (75.0%) of the 48 anti-hcv ... | 1992 | 1297002 |
| hepatitis c virus infection as a risk factor for non-alcoholic liver cirrhosis in taiwan. | to assess whether hepatitis c virus infection was a risk factor for the development of non-alcoholic liver cirrhosis, antibody to hepatitis c virus (anti-hcv; detected by a second generation hcv enzyme immunoassay), hepatitis b surface antigen (hbsag; detected by radioimmunoassay) were tested in 150 cirrhotics and 150 sex-matched and age-matched healthy controls. the prevalence of anti-hcv and hbsag in cirrhotics was higher than in controls (22.0%, 73.3% vs. 2%, 18.7%; p = 0.001). the prevalence ... | 1993 | 7508973 |
| intrafamilial transmission of hepatitis c virus: the important role of inapparent transmission. | to evaluate the intrafamilial transmission of hepatitis c virus (hcv) 104 index patients with type c chronic liver disease and their 307 family contacts were interviewed. after a questionnaire on the risk factors of parenteral exposure, blood samples were obtained and tested for liver biochemistry and anti-hcv antibody by enzyme-linked immunosorbent assay (abbott ii). overall, 52 family contacts (17%) were positive for anti-hcv, indicating a higher anti-hcv prevalence among family contacts than ... | 1994 | 7508492 |
| hepatitis c virus antibody and hepatitis c viremia in pediatric dialysis patients in taiwan. | | 1993 | 7508095 |
| low prevalences of hbv and hcv infection in patients with primary biliary cirrhosis in taiwan: a case control study. | to study the role of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection in patients with primary biliary cirrhosis (pbc) against the background of hbv and hcv infection in the general population, serum specimens from a consecutive series of 27 patients with pbc and 108 age/sex matched 'healthy subjects' as control group were submitted to assays for hepatitis b surface antigen (hbsag), antibody to hepatitis b core antigen (anti-hbc), antibody to hepatitis b surface antigen (anti-hbs) a ... | 1993 | 7506585 |
| hepatitis c virus in a prospective study of posttransfusion non-a, non-b hepatitis in taiwan. | using an enzyme-linked immunosorbant assay for antibody against hepatitis c virus (anti-hcv), serial serum samples from 26 non-a, non-b (nanb) posttransfusion hepatitis (pth) patients were studied in a prospective study in taiwan. sixteen (61.5%) of the 26 patients were positive for anti-hcv antibodies. two of the 16 patients were positive for anti-hcv before transfusion. the remaining 10 patients were negative for anti-hcv antibodies. the rate of anti-hcv seroconversion is, therefore, 58.5%. of ... | 1990 | 2177776 |
| hepatitis c virus infection in patients with chronic liver diseases in an endemic area for hepatitis b virus infection. | taiwan is an endemic area for hepatitis b virus (hbv) infection, which is responsible for up to 80% of chronic liver diseases there. in contrast to an hbv carrier rate of 15-20% in the general population, only 1% of its population are seropositive for anti-hcv. to evaluate the role of hcv infection in chronic liver diseases in taiwan, serum anti-hcv was studied using an enzyme immunoassay in 123 "healthy" administration staff of the hospital, 724 hepatitis b surface antigen (hbsag)-positive and ... | 1991 | 1909260 |
| hepatitis c virus infection in taiwan. | to investigate the epidemiology of hcv in taiwan, anti-hcv was studied by radioimmunoassay or enzyme immunoassay in patients with chronic liver disease, healthy adults, and subjects at risk. the anti-hcv prevalence was 0.95% in 420 volunteer blood donors, 90% in 100 hemophiliacs and 81% in 58 parenteral drug abusers. anti-hcv was present in 6 (7.7%) of 78 hbsag-positive and 28 (65%) of 43 hbsag-negative patients with chronic hepatitis, 3 (10%) of 31 hbsag-positive and 13 (43%) of 30 hbsag-negati ... | 1991 | 1909259 |
| hepatitis b and hepatitis c among institutionalized psychiatric patients in taiwan. | to investigate the seroprevalence of hepatitis b surface antigen (hbsag) and antibodies to hepatitis c virus (anti-hcv) in a psychiatric institution in taiwan, where hepatitis b virus (hbv) is hyperendemic, a total of 780 patients with psychiatric disorders were studied. enzyme-linked immunosorbent assays (elisa) were used for testing hbsag and anti-hcv. the prevalence of hbsag was higher than that of anti-hcv among these patients (18.1% vs. 6.8%, p < 0.0001). the hbsag carrier rate in these pat ... | 1993 | 8360635 |
| a prospective study of post-transfusion non-a, non-b (type c) hepatitis following cardiovascular surgery in taiwan. | in an attempt to investigate the incidence and clinical course of non-a, non-b (nanb) hepatitis following blood transfusion in taiwan, 288 patients who underwent cardiovascular surgery and received blood transfusion were followed prospectively with serum liver aminotransferase levels and viral hepatitis markers for at least six months. none had any past history of liver disease or drug abuse. all blood donors were tested for serum hepatitis b surface antigen and alanine aminotransferase (alt) (g ... | 1991 | 1908889 |
| seroepidemiology of hepatitis c virus infection in taiwan. | the prevalence of antibody to hepatitis c virus among chinese subjects in taiwan was evaluated using a commercially available enzyme immunoassay. the overall prevalence of antibody to hepatitis c virus was 0.28% among 1,419 healthy subjects, 0.8% among 500 unselected paid blood donors and 0.4% among 793 pregnant women. the three offspring of the mothers positive for antibody to hepatitis c virus were all found to be positive for antibody to hepatitis c virus at birth but all became negative by t ... | 1991 | 1851491 |
| antibodies to hepatitis c virus in uremic patients on continuous ambulatory peritoneal dialysis. | the prevalence of antibody to hepatitis c virus (anti-hcv) among 101 uremic patients receiving continuous ambulatory peritoneal dialysis (capd) was evaluated using a synthetic peptide-based hcv antibodies enzyme immunoassay. thirty (29.7%) were found anti-hcv positive. this is significantly higher than 500 unselected paid blood donors (4.2%, p less than 0.0001). among capd patients, anti-hcv positivity was found more frequently in patients who had received frequent and longer duration of hemodia ... | 1991 | 1724984 |
| low prevalence of hepatitis c virus and infrequent perinatal or spouse infections in pregnant women in taiwan. | to assess the prevalence of hepatitis c virus (hcv) infection in the pregnant women in taiwan, we investigated two groups of pregnant women, 944 women without serum alanine aminotransferase (alt) screening (group a) and 197 women with abnormal alt (greater than 45 iu/l) (group b). they were checked for anti-hcv (anti-c100-3) with hcv eia kit (abbott lab., north chicago, il). the results showed that 21 (2.2%) in group a and 5 (2.5%) in group b were anti-hcv-positive. however, 15 out of 21 in grou ... | 1991 | 1724982 |
| prevalence of antibody to hepatitis c virus in pregnant taiwanese. | to assess the prevalence of an antibody to hepatitis c virus (anti-hcv) in pregnant women in taiwan, and elucidate whether or not there is superinfection of the hepatitis b virus (hbv) in such cases, we investigated two independent groups of pregnant women. group a included 294 without serum alanine aminotranferase (alt) screening, and group b included 171 pregnant women with an abnormal alt level (greater than 45 iu/l) who were recruited from 9,523 pregnant women screened for alt. blood samplin ... | 1991 | 1680986 |
| minimal role of hepatitis b virus in posttransfusion non-a, non-b hepatitis in taiwan: a study by polymerase chain reaction. | using the polymerase chain reaction (pcr) for hepatitis b virus (hbv) dna and an enzyme linked immunosorbant assay for the antibody to the hepatitis c virus (anti-hcv), we studied the serum samples of 18 patients with posttransfusion non-a, non-b (nanb) hepatitis in a prospective study. they were all negative for both the hepatitis b surface antigen (hbsag) and the igm antibody to the hepatitis b core antigen (igm anti-hbc) by radioimmunoassay and were all negative for hepatitis b virus (hbv) dn ... | 1991 | 1680985 |
| a nested case-control study on association between hepatitis c virus antibodies and primary liver cancer in a cohort of 9,775 men in taiwan. | most studies on the association between antibodies against hepatitis c virus (anti-hcv) and primary liver cancer (plc) were limited to case-series, or cross-sectional case-control studies leaving a controversy on causal temporality. a nested case-control study on 38 newly-developed plc patients and 152 matched controls selected from a cohort of 9,775 men in taiwan recruited from september, 1984, to february, 1986, was carried out to examine the relation between hcv infection and plc. case-contro ... | 1994 | 7523582 |
| antibodies to hepatitis e virus among chinese patients with acute hepatitis in taiwan. | the prevalence of antibodies to hepatitis e virus (anti-hev) was investigated in patients with acute hepatitis, and correlated with the clinical features. sera from 110 patients with acute hepatitis and 60 healthy controls were tested for anti-hev, antibody to hepatitis c virus (anti-hcv), and hepatitis b surface antigen (hbsag). there were significant differences in the prevalence of anti-hev, anti-hcv, and hbsag between patients and controls (21.8% vs. 0%, 16.3% vs. 1.6% and 58.1% vs. 18.0%, r ... | 1994 | 7525864 |
| genotypes of hepatitis c virus in taiwan and the progression of liver disease. | the existence of four genotypes of hepatitis c virus (hcv)--types 1a, 1b, 2a, and 2b--has been suggested based on variations in nucleotide sequences of the core region. the aim of this study was to investigate the prevalence of hcv genotypes in chronic type c liver disease in taiwan and correlate distinct genotypes to severity of liver disease. the genotypes of 175 patients with chronic type c liver disease were determined by a polymerase chain reaction with type-specific primers. the prevalence ... | 1995 | 8648060 |
| intrafamilial transmission of hepatitis c virus in hemodialysis patients. | the prevalence of hepatitis c virus (hcv) infection in chronic hemodialysis patients ranges from 20 to 50% and these patients may serve as a reservoir of infection for their household contacts. the aim of this study was to investigate the prevalence of anti-hcv in hemodialysis patients and their families, and to evaluate possible routes of infection. one hundred eighty-six family members of 84 hemodialysis patients and 529 healthy adults were enrolled. the family members consisted of 50 spouses, ... | 1995 | 7545208 |
| injection with nondisposable needles as an important route for transmission of acute community-acquired hepatitis c virus infection in taiwan. | a prospective case-controlled study was conducted in order to determine the transmission route of community-acquired hepatitis c virus (hcv) infection in taiwan. thirty-eight consecutive patients (25 men and 13 women) with acute community-acquired hcv infection and 76 age (within 3 years)- and sex-matched healthy control subjects without hcv infection were enrolled. serum anti-hcv was tested by second generation immunoassay. the sera of 26 family members from 12 families of index patients were a ... | 1995 | 7561798 |
| low prevalence of hepatitis c virus infection among dentists in taiwan. | to evaluate whether hepatitis c virus (hcv) infection is an occupational hazard in the dental environment, serum samples collected in 1990-1991 from 461 dentists were tested for the antibody to hcv (anti-hcv) with first- and second-generation hcv enzyme-linked immunoassays (eias). five of the 363 (1.38%) serum samples were reactive by the first-generation (c100-3) hcv eia. of the same 363 samples and the other 98 samples, 3 (0.65%) were reactive by the second-generation test. of the 5 first-gene ... | 1993 | 7685807 |
| the role of hepatitis c virus in chronic hepatitis b virus infection. | to investigate the influence of hepatitis c virus (hcv) infection on patients with chronic hepatitis b virus (hbv), the presence of antibody against c100-3 antigen of hcv (anti-hcv) was examined in 420 patients with chronic hbv infection and 275 healthy subjects. it was found that the prevalence of hcv infection increased in parallel with the severity of liver damage. the positive rates of anti-hcv were as follows: healthy subjects, 2.9% (8/275); asymptomatic carriers, 2.6% (5/193); chronic hepa ... | 1993 | 7689504 |
| liver disease after bone marrow transplantation--the taiwan experience. | to investigate the causes of impaired liver function (lf)* after bmt, 88 patients were included for analysis of hepatitis b virus (hbv) and hepatitis c virus (hcv) infections, transplant methods, preconditioning regimens, and graft-versus-host disease (gvhd). fifty of them (56.8%) developed abnormal lf after bmt and among them, 29 (32.9%) developed chronic hepatitis (ch). by univariate analysis, hcv infection, pretransplant abnormal lf, allogeneic bmt, and preconditioning regimen with total body ... | 1995 | 7732560 |
| genotype distribution of hepatitis c virus infection in taiwan. | to investigate the prevalence of genotype distribution of hepatitis c virus (hcv) infection in taiwan, genotypes were identified in 122 (36 anti-hcv-positive blood donors, 44 anti-hcv-positive aborigines, 28 hemodialysis patients, and 14 patients with chronic liver diseases) of 280 subjects, using polymerase chain reaction by okamoto's type-specific primer method. type ii was the dominant (66.7%) type among anti-hcv-positive blood donors, followed by type iii and type iv with the same percentage ... | 1994 | 7798889 |
| sequence determination of hepatitis c virus genome isolated from taiwan. | the partial genome sequence of the hepatitis c virus (hcv) was determined in the serum of a taiwanese patient with chronic community-acquired type c hepatitis. the cdna fragments synthesized with the hcv rna as a template were amplified by polymerase chain reaction using specific oligonucleotide primers. the amplified fragments represented the regions coding for the putative core, matrix and envelope proteins as well as the n-terminal amino acid sequence of the nonstructural protein ns1, the par ... | 1994 | 7866053 |
| transfusion-transmitted human t-cell lymphotropic virus type i infection in taiwan: a true risk and occasional coinfection with hepatitis c virus shown in a prospective study. | to study the incidence of human t-cell lymphotropic virus (htlv) after blood transfusion in taiwan, serum samples from 699 patients in a prospective study were examined for seroreactivity of anti-htlv. by an enzyme immunoassay, 9 of the 699 recipients were repeatedly positive. serial serum samples of these 9 patients were then confirmed with a western blot analysis and with a polymerase chain reaction (pcr) assay for htlv-i genome. four were already positive for anti-htlv before transfusion, 1 c ... | 1994 | 7913844 |
| hepatitis c virus infection among patients with chronic liver disease in an area hyperendemic for hepatitis b. | the prevalence of hepatitis c virus (hcv) infection was assessed in patients with non-alcoholic chronic liver disease (cld). | 1994 | 8079115 |
| multiple viral infection as the most common cause of fulminant and subfulminant viral hepatitis in an area endemic for hepatitis b: application and limitations of the polymerase chain reaction. | we tested serum samples from 25 fulminant hepatitis and 7 subfulminant hepatitis patients for hepatitis a, b, c, d and e viral markers and nucleic acids by means of polymerase chain reaction to determine the role of each virus on such catastrophic events in an area endemic for hepatitis b. of these 32 patients, 14 (44%) were hepatitis b virus carriers with hepatitis d virus superinfection (1 with hepatitis c virus infection), 3 others had coexisting hepatitis b virus and hepatitis c virus infect ... | 1994 | 8138254 |
| seroprevalence of antibody to hepatitis e virus among chinese subjects in taiwan. | recently, with an available serological hepatitis e virus diagnostic kit, the prevalence of igg antibody to hepatitis e virus among chinese subjects in taiwan was evaluated by means of a solid-phase enzyme-linked immunoassay based on two recombinant hepatitis e virus antigens. the overall prevalence of hepatitis e virus antibody was 10.7% among 384 healthy subjects older than 20 yr but only 0.3% among 600 schoolchildren and young adolescents younger than 20 yr (p < 0.0001). serial serum samples ... | 1994 | 8138258 |
| possible role of high-titer maternal viremia in perinatal transmission of hepatitis c virus. | to study perinatal transmission of hepatitis c virus (hcv), 15 anti-hcv-positive carrier mothers without human immunodeficiency virus coinfection were recruited. at delivery, maternal blood was taken and anti-hcv titer was determined and hcv rna measured in each serum sample by reverse transcription polymerase chain reaction (pcr). a competitive pcr was used in selected samples to quantitate hcv concentration. the 15 neonates were followed regularly for 1 year and their sera were also assayed fo ... | 1994 | 8158040 |
| comparison of three different immunoassays and pcr for the detection of hepatitis c virus infection in pregnant women in taiwan. | to compare different hepatitis c virus (hcv) immunoassays and hcv-rna in pregnant women, we investigated two independent groups: 1,687 cases without screening for serum alanine aminotransferase (alt) (group a) and 333 cases with elevated alt (> 45 iu/l) (group b), after screening 21,459 pregnant women. in group a, 11 (0.65%) and 21 (1.24%) were anti-hcv-positive by first- and second-generation tests, respectively, while in group b 8 (2.40%) and 19 (5.71%) were positive, respectively. the results ... | 1993 | 8212666 |
| gb virus-c/hepatitis g virus infection in an area endemic for viral hepatitis, chronic liver disease, and liver cancer. | gb virus-c/hepatitis g virus (gbv-c/hgv) is a newly identified flavivirus, and little is known about its clinical significance. gbv-c/hgv was investigated in different populations, and its coinfection was investigated in patients with liver disease in taiwan where hepatitis b and c are endemic. | 1997 | 9098011 |
| hepatitis b and c virus infection as risk factors for hepatocellular carcinoma in chinese: a case-control study. | to assess whether hepatitis b and c virus infection were risk factors for hepatocellular carcinoma (hcc), antibody to hepatitis c virus (anti-hcv), hepatitis b surface antigen and e antigen (hbsag and hbeag) were tested in 150 hcc patients. another 150 case-control pairs matched individually by sex and age were also enrolled. univariate analysis demonstrated that both the anti-hcv and the carrier status of hbsag and hbeag were significantly associated with hcc. multi-variate analysis revealed th ... | 1994 | 8314335 |
| hepatitis c virus infection in volunteer blood donors in taiwan. evaluation by hepatitis c antibody assays and the polymerase chain reaction. | a total of 2671 plasma samples that were selected from 22,500 volunteer blood donors in taiwan were studied for hepatitis c virus (hcv) infection. the donors were stratified into three groups by serum alanine aminotransferase (alt) levels. of the donors, 20,768 (92.3%) had an alt level less than 30 iu/l (group 1), 1080 (4.8%) had an alt level between 31 and 45 iu/l (group 2), and 652 (2.9%) had an alt level greater than 45 iu/l (group 3). to study anti-c100-3 hepatitis c antibody, 2023 plasma sa ... | 1993 | 8381269 |
| elevated serum testosterone levels and risk of hepatocellular carcinoma. | serum samples of 9691 male adults had been collected and frozen for a prospective study of hepatocellular carcinoma in taiwan. after an average follow-up period of 4.6 years, testosterone levels in the stored serum were measured by radioimmunoassay using commercial kits for 35 cases of newly developed hepatocellular carcinoma, 63 hepatitis b surface antigen-negative and 77 hepatitis b surface antigen-positive matched controls. elevated testosterone levels were found to be associated with an incr ... | 1993 | 8381328 |
| prevalence of hepatitis c viral infection in a community in taiwan. detection by synthetic peptide-based assay and polymerase chain reaction. | the prevalence of antibodies to hepatitis c virus (anti-hcv) in a hepatitis b virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. a general population of 1500 from northern taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural protein region as the solid-phase antigen. a total of 37 subjects out of 1500 (2.5%) were positive, with no significant difference in distribution between hepatitis b antigenemic and no ... | 1993 | 8383160 |
| high incidence of hepatitis c virus infection in hemodialysis patients in taiwan. | a longitudinal follow up of 202 hemodialytic patients were conducted to evaluate the incidence of hepatitis c virus (hcv) infection in this high-risk group. a total of 113 patients were found to be seronegative for anti-hcv at the start of this study period. during the average follow-up period of 39 months, 51 patients developed anti-hcv later (group i), while the remaining 62 patients (group ii) were seronegative throughout the study period. the results showed that the incidence of hcv seroposi ... | 1993 | 8447305 |
| prevalence, infectivity, and risk factor analysis of hepatitis c virus infection in prostitutes. | a population of 622 prostitutes in taiwan was tested for antibodies to the hepatitis c virus (anti-hcv) using a synthetic peptide assay composed of representative determinants from capsid and nonstructural (ns) viral proteins. seventy-four (12%) were positive and the remaining 548 (88%) were negative. seventy-nine samples were retested by a second-generation anti-hcv assay composed of recombinant capsid and ns proteins of hcv. both assays had a nearly perfect agreement (kappa value = 0.91). of t ... | 1993 | 8492103 |
| effect of hepatitis c antibody screening in blood donors on post-transfusion hepatitis in taiwan. | a national screening programme for antibody to hepatitis c virus (hcv) in blood donors in taiwan began in july 1992 using a second-generation immunoassay. to study the impact of this screening on post-transfusion hepatitis in taiwan, a prospective study on post-transfusion hepatitis, that was started in 1987, was continued. as of june 1994, 245 patients who received a blood transfusion after july 1992 had completed a follow-up period for more than 6 months post-transfusion. of them, seven (2.8%) ... | 1995 | 8527713 |
| alcoholism, hepatitis b and c viral infections, and impaired liver function among taiwanese aboriginal groups. | viral hepatitis and alcoholism prevail in four major taiwanese aboriginal groups. to study the relative importance of the acquisition of hepatitis b virus or hepatitis c virus infection and alcoholism to the presence of impaired liver function in these groups, the authors conducted a semistructured clinical interview for alcoholism and test for seromarkers for viral hepatitis among 993 cohort members enrolled in 1990-1992 in an ongoing prospective study (taiwan aboriginal study project). the sub ... | 1996 | 8610707 |
| prevalence and manifestations of hepatitis c seropositivity in children in an endemic area. | according to our previous studies, paisha township in penghu islets is an endemic area for hepatitis b virus and hepatitis c virus (hcv) infection and for hepatocellular carcinoma. we conducted this study to understand the prevalence of anti-hcv seropositivity among children in this area and to observe clinical manifestations of anti-hcv-positive children. | 1998 | 9493811 |
| effects of gb virus-c/hepatitis g virus on hepatitis b and c viremia in multiple hepatitis virus infections. | we found that patients with dual hbv and gbv-c/hgv infection had comparable serum hbv dna positivity and mean virus concentration compared with age-matched hbv carriers, and those with triple infection had a significantly lower hbv dna positivity. serum hcv rna positivity and mean virus titer were similar between hcv carriers with or without gbv-c/hgv co-infection, and those with gbv-c/hgv co-infection seemed to have a lower serum alt level. these data suggest that gbv-c/hgv infection exerts no ... | 1998 | 9638149 |
| prevalence, genotypes and antibody titer of hepatitis c virus in pregnant women in taiwan. | to investigate the prevalence and genotypes of hepatitis c virus (hcv) in pregnant women in taiwan, as well as to examine whether any correlation occurs between hcv genotype and anti-hcv titer. | 1995 | 8640465 |
| additive effect modification of hepatitis b surface antigen and e antigen on the development of hepatocellular carcinoma. | to assess the role of hepatitis b e antigen (hbeag) and its interaction with hepatitis b surface antigen (hbsag) on the development of hepatocellular carcinoma (hcc), this case-control study included 361 age- and sex-matched pairs of patients with histologically proven hcc and healthy control subjects. hbsag, hbeag and antibody to hbeag (anti-hbe) were detected by radioimmunoassay. antibodies to hepatitis c virus (anti-hcv) were detected by second-generation enzyme immunoassay. the prevalences o ... | 1996 | 8664119 |
| [community-based hepatocellular carcinoma screening in seven townships in taiwan]. | the early detection and prompt treatment of hepatocellular carcinoma (hcc) may prolong life and improve the quality of life of affected patients. in order to compare sensitivity and specificity of various screening biomarkers, identify subjects with a high risk of developing hcc, and estimate prevalence and incidence of hcc among subjects, a community-based hcc screening program was implemented in sanchi, chutung, potzu, and kaohsu, taiwan island as well as makung, huhsi and paihsa in penghu isl ... | 1995 | 8672950 |
| serotyping of hepatitis c virus in chronic type c hepatitis in taiwan: correlation with genotypes. | to evaluate the usefulness of a new serologic assay to group hepatitis c virus (hcv), genotypes identified by this serotyping method were compared to those identified by a polymerase chain reaction (pcr) assay with type-specific primers in 71 taiwanese patients with chronic type c hepatitis. the group-specific antibodies against different hcv genotypes were detected by using an enzyme-linked immunosorbent assay (elisa) based on group-specific recombinant peptides (c14-1 and c14-2) within the ns4 ... | 1996 | 8680542 |
| clinical significance of portal lymphoid aggregates/follicles in chinese patients with chronic hepatitis c. | portal lymphoid aggregates/follicles (lymphoid a/f) is a characteristically histological finding in patients with chronic hepatitis c. we assessed the prevalence of lymphoid a/f in chinese patients with chronic hepatitis c and evaluated the correlation of this phenomenon with clinical, biochemical, immunological, virological, and other histological features of these patients. | 1999 | 10201474 |
| minimal role of gb virus-c/hepatitis g virus in fulminant and subfulminant hepatitis in taiwan. | the role of gb virus-c/hepatitis g virus (gbv-c/hgv) in fulminant hepatitis (fh) and subfulminant hepatitis (sfh) remains unclear. | 1999 | 10207785 |
| risk factors of hepatitis c virus infection in a taiwanese aboriginal community. | the aim of this study is to identify the risk factors associated with anti-hcv positive status in a bunun aboriginal community in taiwan. in a door-to-door survey we collected 712 blood samples, and employed an enzyme immunoassay for anti-hcv to detect the recombinant antigen of viral genome including one structural and two nonstructural proteins. the prevalence of anti-hcv was 16.9% for the whole community covering an age range of five years to 84 years, but it was 48% in individuals older than ... | 1996 | 8683646 |
| elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. | to elucidate the importance of aflatoxin in the etiology of hepatocellular carcinoma (hcc), a community-based cohort study combined with molecular dosimetry of aflatoxin exposure was performed in the penghu islets where the hcc mortality rate is highest in taiwan. a total of 6,487 residents aged 30 to 65 years were recruited in the two-stage screening survey and underwent regular follow-up examination. among 33 newly diagnosed hcc cases, 31 (94%) were chronic hepatitis b surface antigen (hbsag) ... | 1996 | 8707279 |
| serotypes, genotypes and levels of hepatitis c viremia in pregnant women in taiwan. | the correlation between a new serotyping method for grouping different genotypes of hepatitis c virus (hcv) and those identified by a polymerase chain reaction (pcr) assay with type-specific primers was investigated in 3,400 pregnant women. the correlation between hcv genotypes and serum hcv levels in hcv-positive pregnant women was studied as well. the new serologic assay used an enzyme-linked immunosorbent assay (elisa) based on highly group-specific recombinant peptides (c14-1 and c14-2) with ... | 1996 | 8772047 |
| superinfection with hepatitis c virus in hemodialysis patients with hepatitis b surface antigenemia: its prevalence and clinical significance in taiwan. | a survey of hepatitis b surface antigen (hbsag) and antibodies against hepatitis c virus (anti-hcv) in 173 patients undergoing hemodialysis in taiwan revealed that 15 (9%) patients were positive for both hbsag and anti-hcv, 106 (61%) were positive for anti-hcv alone, and 14 (8%) were positive for hbsag alone. most hbsag positivity was acquired before the onset of hemodialysis. anti-hcv positivity, however, was mainly acquired via the hemodialysis procedure. patients with dual markers were younge ... | 1996 | 8773337 |
| prevalence of tt virus dna in eastern taiwan aborigines. | we studied the prevalence of tt virus (ttv) dna in the general population of the eastern taiwan aborigine villages, about 11% (34 of 317). there is no association between the presence of hbsag and ttv dna or between the presence of hcv rna and ttv dna. therefore, the infection of hbv or hcv and the presence of ttv dna appear to be independent from each other. the association between the presence of ttv dna and the elevated alanine aminotransferase (and/or aspartate aminotransferase) activity was ... | 1999 | 10459156 |
| a prospective study of transfusion-transmitted gb virus c infection: similar frequency but different clinical presentation compared with hepatitis c virus. | to study the incidence and outcome of gb virus c (gbv-c) infection in blood recipients. serum samples collected in a prospective study were examined for gbv-c rna by a nested polymerase chain reaction assay. among the 400 adults who underwent cardiac surgery, 40 were positive for gbv-c rna, including six whose pretransfusion sera were already positive and seven coinfected with hepatitis c virus (hcv) during transfusion. the risk of transmission was estimated to be approximately 0.46% per donor. ... | 1996 | 8781448 |
| antibodies to hepatitis e and a viruses among patients with non-alcoholic chronic liver disease in taiwan. | the prevalence of hepatitis e virus (hev) and hepatitis a virus (hav) infection in patients with non-alcoholic chronic liver disease (cld) was assessed. | 1994 | 7939403 |
| a clinicopathologic study of chronic non-a, non-b (type c) hepatitis in taiwan: comparison between posttransfusion and sporadic patients. | to elucidate the clinicopathological course and the role of hepatitis c virus in posttransfusion and sporadic chronic non-a, non-b hepatitis in taiwan, we retrospectively studied 85 histologically confirmed patients with long-term follow up. antibodies against hepatitis c virus (anti-hcv) by a second-generation assay were positive in 81% of the patients: 88% in the posttransfusion group and 76% in the sporadic group. clinical manifestations were generally mild, and were noted in only half of the ... | 1994 | 7989717 |
| transmission of hepatitis c virus between spouses: the important role of exposure duration. | although interspousal transmission of hepatitis c virus (hcv) has been studied, the factors responsible for it remain unclear. | 1996 | 8855726 |
| incidence of post-transfusion hepatitis in taiwan before and after introduction of anti-hcv testing. | the effectiveness of second-generation anti-hepatitis c virus antibody (anti-hcv) screening of blood donations for the prevention of non-a, non-b post-transfusion hepatitis (nanb pth) was assessed. a prospective study of 192 transfusion recipients was performed to compare the incidence of nanb pth after the introduction of the second-generation anti-hcv test with the incidence before its introduction. we used a polymerase chain reaction to detect hcv-rna and hbv-dna in the sera of patients with ... | 1996 | 8873008 |
| hepatitis c virus in chronic liver disease and hepatocellular carcinoma in taiwan. | hepatitis b virus (hbv) has long been known to be the major etiologic factor of chronic liver diseases and hepatocellular carcinoma (hcc), and in taiwan 80-90% of chronic liver diseases and hcc are caused by hbv. assays for antibody to hepatitis c virus (hcv) and to detect its viral genome (hcv-rna) have revealed hcv as the next most common cause of these diseases in taiwan. the prevalence of antibody to hcv (anti-hcv) in hepatitis b surface antigen (hbsag)-negative patients is around 70-80%, an ... | 1995 | 8875606 |
| the genotypes of hepatitis c virus in patients with chronic hepatitis c virus infection in southern taiwan. | to investigate the genotype distribution of hepatitis c virus (hcv) in southern taiwan, the sera from 56 patients with chronic hcv infection were studied. twenty-nine patients were men and 27 were women. age ranged from 22 to 65 years (mean, 47.3 +/- 11.4). eighteen of them had chronic persistent hepatitis, 27 had chronic active hepatitis, and 11 had liver cirrhosis. hcv rna was detected by reverse transcription-nested polymerase chain reaction using primers derived from the 5'-noncoding region. ... | 1996 | 8953853 |
| seroprevalences of hepatitis b and c viruses and helicobacter pylori infection in a small, isolated population at high risk of gastric and liver cancer. | the objective of this study was to examine the seroprevalences of chronic infection with hepatitis b and c viruses and helicobacter pylori in matzu, a group of small islets with 5,566 civilian residents who have extremely high mortality from cancers of the stomach and liver. the standardized mortality ratios (smr) of all cancer sites combined, liver cancer and stomach cancer in 1984-1993 were calculated using the general population in taiwan as the referent (smr = 100). the smrs (95% confidence ... | 1997 | 9180145 |
| hepatitis c and g virus infections in polytransfused children. | the prevalence of hepatitis c virus (hcv) and a newly identified hepatitis g virus (hgv) and their clinical significance were studied in 42 polytransfused taiwanese children. serological assays for antibodies against hcv (anti-hcv) and polymerase chain reaction for serum hcv ribonucleic acid (rna) and hgv rna were performed. the prevalence of anti-hcv and hgv rna was 17% and 14%, respectively in 42 polytransfused children. anti-hcv seropositives had a significantly higher mean age, peak serum tr ... | 1997 | 9243238 |
| different viral aetiology of hepatocellular carcinoma between two hepatitis b and c endemic townships in taiwan. | in taiwan, we found two hepatitis b virus (hbv)- and hepatitis c virus (hcv)-endemic townships, paisha and tzukuan, with an anti-hcv prevalence of 19 and 37% in men, and 26 and 38% in women, respectively. the hepatitis b surface antigen (hbsag)-positive rates were 25 and 18%, for men and women in paisha, and 25 and 22% in tzukuan, respectively. according to the national death certification database (1982 to 1991), the annual age-adjusted mortality rates per 100,000 population for liver cancer am ... | 1997 | 9257249 |
| high rate of hepatitis c virus infection in an isolated community: persistent hyperendemicity or period-related phenomena? | we investigated underlying risks for hyperendemic hepatitis c virus (hcv) infection among the 1853 inhabitants of a mountainous village in eastern taiwan with high prevalence of hcv and hepatitis b virus (hbv). among the 80 selected adults, we found that having resided away from the village before 1985 was protective against hcv infection, while residing in the village after 1985 posed little risk for hcv infection to children and young adults < 30 years of age. among the 559 school children 7 t ... | 1997 | 9260682 |
| gb virus-c/hepatitis g virus infection in prostitutes: possible role of sexual transmission. | the modes of transmission of gb virus-c/hepatitis g virus (gbv-c/hgv) other than by blood transfusion are largely unknown. the prevalence of gbv-c/hgv viremia and the associated risk factors in 145 female prostitutes were examined. the seroprevalence of hepatitis b surface antigen (hbsag), antibodies to hepatitis c virus (anti-hcv), and gbv-c/hgv rna were 14%, 18%, and 11%, respectively. the demographic characteristics were similar between subjects with and without hbsag. in contrast, those with ... | 1997 | 9260684 |
| viral hepatitis in continuous ambulatory peritoneal dialysis patients in an endemic area for hepatitis b and c infection: the taiwan experience. | the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv), and their associations in 64 continuous ambulatory peritoneal dialysis (capd) patients (30 males and 34 females) were evaluated. a comparison was also made with 526 normal controls (266 males and 260 females). forty-seven (75%) capd patients were anti-hbc positive, with no significant difference to the control group (81.9%). this probably reflects acquisition of hbv infection by capd patients before initiation of chronic dialysi ... | 1997 | 9262846 |
| gb virus-c/hepatitis g virus infection in a hepatitis c virus endemic village: prevalence in residents with low educational attainment and frequent recovery in females. | gb virus-c/hepatitis g virus (hgv) is a newly identified flavivirus, which may share the same mode of transmission as hepatitis c virus (hcv). the aim of this study was to investigate associated factors of hgv infection and clearance in a hcv endemic village in southern taiwan. | 2000 | 10902972 |
| serotyping and genotyping of hepatitis c virus in taiwanese patients with type c chronic liver disease and uraemic patients on maintenance haemodialysis. | to evaluate a recombinant immunoblot hepatitis c virus (hcv) serotyping assay, which determines hcv serotypes 1, 2, and 3 by detecting type-specific antibodies to core-and ns-4-derived peptides. | 2000 | 10937687 |
| incidence of hepatitis c infection in a hepatitis c endemic township in southern taiwan. | to realize the incidence of hepatitis c virus (hcv) infection in an hcv endemic township, tzukuan, in taiwan, we conducted a follow-up community-based survey. a total of 173 adults, 82 males and 91 females, with mean age of 55.5 +/- 9.9 years received initial and follow-up anti-hcv tests with one-year interval. one (1.2%, 95% ci: 0%-5.5%) of 84 anti-hcv-positive subjects was negative-seroconversion, and 4 (4.5%, 95% ci: 0.2%-8.8%) of 89 anti-hcv-negative subjects were positive-seroconversion. th ... | 1997 | 9385776 |
| using the prevalence of an elevated serum alanine aminotransferase level for identifying communities with a high prevalence of hepatitis c virus infection. | antibody to hepatitis c virus (anti-hcv) is a widely accepted method for the diagnosis of hcv infection. however, it is too expensive to use in large-scale health surveys. | 2001 | 11176765 |
| distribution of hepatitis c virus genotypes among blood donors in taiwan. | the aim of this study was to investigate the prevalence and distribution of hepatitis c virus (hcv) genotypes of blood donors in taiwan. rna was extracted from the serum of anti-hepatitis c virus-positive carriers and this was followed by reverse transcriptase-polymerase chain reaction (rt-pcr) using type-specific primers for the presence of hcv genotypes, 1a, 1b, 2a, 2b, 3a and 6a. of the 604 anti-hcv-positive specimens, the pcr demonstrated that 93.0% (562/604) were positive for at least one h ... | 1997 | 9407323 |
| relationships between serum aminotransferase levels, liver histologies and virological status in patients with chronic hepatitis c in taiwan. | in patients with chronic hepatitis c, the relationships between serum alanine aminotransferase (alt) levels, histological liver injury and serum hepatitis c virus (hcv) rna titres remain controversial. to evaluate these relationships, 93 chinese patients with histological diagnosis of chronic hepatitis c were enrolled for this study. serum alt levels, hcv-rna titres and hcv genotypes were examined. the histology was evaluated according to a modified histological activity score based on the degre ... | 1998 | 9715418 |
| detection of serum hepatitis b, c, and d viral nucleic acids and its implications in hepatocellular carcinoma patients. | the association of viremia, elevated serum alanine aminotransferase (alt) levels, and hepatocyte inflammatory activity in hepatocellular carcinoma (hcc) patients was studied. serum samples from 114 hcc patients undergoing surgery were assayed for hepatitis b, c, and d viral nucleic acids by polymerase chain reaction (pcr) prior to surgery. of these patients, 65 had hbv infection alone, 15 had hcv infection alone, 4 had hdv infection, 20 had hbv and hcv superinfection, 1 had triple viral infectio ... | 1998 | 9719234 |
| risk factors associated with hepatitis c virus infection in taiwanese government employees. | this study evaluated the roles of multiple factors in hepatitis c virus (hcv) infection, with emphasis on the modification of various individual characteristics on the risk associated with percutaneous exposure to blood. serum samples taken from 4869 men in taiwan within a cohort study were tested for hcv antibody. the overall positive rate of anti-hcv was 1.6%. in a logistic regression, factors positively associated with anti-hcv positivity were previous blood transfusion (odds ratio [or] = 7.2 ... | 2001 | 11349980 |
| differences in risk factors for being either a hepatitis b carrier or anti-hepatitis c+ in a hepatoma-hyperendemic area in rural taiwan. | this is a study of the differences in the risk factors for being either hepatitis b surface antigen positive [hbsag(+)] or antibody to hepatitis c virus positive [anti-hcv(+)] in a-lein, a rural area in southern taiwan, an area which also has a high hepatoma mortality rate. three hundred eighty-five patients age > or =40 years participated in hepatoma screening at the a-lein community health center during 1995. those who were hbsag(-) and anti-hcv(-) or had coinfection of hbsag(+) and anti-hcv(+ ... | 1998 | 9731921 |
| seroepidemiology of hepatitis c virus infection among drug abusers in southern taiwan. | the purpose of this study was to determine the risk factors for hepatitis c virus (hcv) infection among drug abusers in southern taiwan. this survey included 935 drug abusers from kaohsiung narcotic abstention institute and kaohsiung prison. the prevalence of anti-hcv antibody was 29.1% among male drug abusers and 19.4% among female drug abusers. the seroprevalence of anti-hcv antibody was 66.4% among intravenous drug abusers and 14.4% among nonintravenous drug abusers. intravenous drug use, a h ... | 1998 | 9884484 |
| etiology of sporadic acute viral hepatitis in taiwan: the role of hepatitis c virus, hepatitis e virus and gb virus-c/hepatitis g virus in an endemic area of hepatitis a and b. | the etiology of sporadic acute hepatitis was studied in 334 consecutive patients from taiwan (237 men and 97 women, aged 16-81 years), with emphasis on the role of hepatitis c virus (hcv), hepatitis e virus (hev), and gb virus-c/hepatitis g virus (gbv-c/hgv) in acute non-a, non-b (nanb) hepatitis and in hbsag carriers with superimposed acute hepatitis. according to the conventional diagnostic criteria, there were 12 cases (3.6%) of acute hepatitis a, 17 cases (5.1%) of acute hepatitis b, 128 cas ... | 1999 | 10335863 |
| gb virus c infection in hemodialysis patients: molecular evidence for nosocomial transmission. | studies of the prevalence and clinical relevance of gb virus c (gbv-c) infection in 328 hemodialysis (hd) patients were done, and the possibility of nosocomial gbv-c transmission was explored by molecular epidemiology methods. for gbv-c viremic patients in a given hd unit, nucleotide sequences of the envelope region were analyzed by phylogenetic tree constructions. of 328 hd patients, active hepatitis b virus, hepatitis c virus (hcv), and gbv-c infection were detected in 13%, 23%, and 17%, respe ... | 1999 | 10353878 |
| gb virus-c/hepatitis g virus infection in taiwan: a virus that fails to cause a disease? | recently, an rna virus designated gb virus-c or hepatitis g virus (gbv-c/hgv) was identified; however, its clinical significance remains uncertain. this discovery prompted us to investigate the virological, epidemiological and clinical implications of gbv-c/hgv infection in taiwan where chronic liver diseases and liver cancer are endemic. our results showed that genetic heterogeneity of gbv-c/hgv isolates exists, and primers from the highly conserved 5' untranslated region of viral genome can ef ... | 1999 | 10420079 |
| gb virus c/hepatitis g virus infection in chronic hepatitis c patients with and without interferon-alpha therapy. | gb virus c/hepatitis g virus (gbv-c/hgv) rna, detected by polymerase chain reaction, and antibodies to the gbv-c/hgv envelope protein (anti-e2), detected by an enzyme-linked immunosorbent assay, were used to evaluate both the impact of gbv-c/hgv on the coexistent hepatitis c virus (hcv) infection and the course of gbv-c/hgv infection in chronic hepatitis c patients with and without interferon-alpha (ifn-alpha) treatment. of the 162 chronic hepatitis c patients treated with inf-alpha, 17.9% were ... | 2001 | 11675141 |
| plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection. | both experimental and epidemiologic studies have linked a low dietary intake of selenium with an increased risk of cancer. the authors examined the association between plasma selenium levels and risk of hepatocellular carcinoma (hcc) among chronic carriers of hepatitis b and/or c virus in a cohort of 7,342 men in taiwan who were recruited by personal interview and blood draw during 1988-1992. after these men were followed up for an average of 5.3 years, selenium levels in the stored plasma were ... | 1999 | 10453813 |
| paraneoplastic syndromes in patients with hepatocellular carcinoma in taiwan. | hepatocellular carcinoma (hcc) is the most common malignancy in taiwan. some patients may manifest paraneoplastic syndromes during the clinical course of the disease. in this study, the authors evaluated the clinical significance of these paraneoplastic syndromes, compared the prevalence of these syndromes between cases of hepatitis b virus (hbv)-related and hepatitis c virus (hcv)-related hcc, and estimated significant predictors associated with the syndromes. | 1999 | 10463978 |