fatal basilar vasculopathy complicating bacterial meningitis.bacterial meningitis complicated by thrombosis, vasculitis, and aneurysm formation affecting both small and distal branches of cerebral vessels has been well described. involvement of major cerebral vessels is rare and has only been documented late in the course of disease.19921636194
hyaluronidase production in streptococcus milleri in relation to hundred and seven (41%) of 262 isolates of streptococcus milleri, from human sources, produced hyaluronidase. hyaluronidase production was commoner in beta haemolytic isolates 32 of 39 (82%), many of which were of lancefield group f. but hyaluronidase was also found in alpha and non-haemolytic isolates, and in groups a, c, g, and non-groupable isolates. there was a strong association between hyaluronidase production and isolation from known internal abscesses (48/58, 83%) compared with isola ...19892732345
pig bite injuries and infection: report of seven human cases.six patients developed local infection after being bitten or gored by swine. wounding was often deep and occurred characteristically on the posterior aspect of the thigh. severity of infection varied from simple wound infection with discharge and slough to cellulitis and abscess formation; pathogens included haemolytic streptococci, pasteurellae, bacteroides sp., proteus sp. and escherichia coli and were usually isolated in mixed culture. a patient with pasteurella aerogenes infection appears to ...19883215292
the effect of indigenous bacterial populations on buccal epithelial cells on subsequent microbial adhesion in vitro.despite the numerous investigations on the adhesion of microorganisms to buccal epithelial cells, it is difficult to correlate different results, as disparate adherence values have been reported for a given organism. as one reason for this disparity may be the indigenous or natural bacterial populations on human buccal epithelial cells, the effect of the latter on subsequent microbial adherence in vitro was examined. there was a highly significant correlation between the degree of natural bacter ...19947478764
characterization of glucosyltransferaseb, gtfc, and gtfd in solution and on the surface of hydroxyapatite.glucosyltransferaseb, gtfc, and gtfd were purified by hydroxyapatite column chromatography, followed by ultrafiltration from the culture supernatant fluids of three streptococcus milleri constructs (gift from dr. h.k. kuramitsu) which harbored individual gtf genes of streptococcus mutans gs5. gtfb, gtfc, and gtfd were enzymatically active both in solution and in an experimental pellicle (ha-cws-gtf) formed by adsorbing gtf onto the surface of clarified human whole saliva (cws)-coated hydroxyapat ...19957499593
pathogenicity of the streptococcus milleri group in pulmonary infections--effect on phagocytic killing by human polymorphonuclear neutrophils.the pathogenicity of streptococcus constellatus in pulmonary infections was investigated in mice in correlation with the phagocytic killing of the microorganisms by human polymorphonuclear neutrophils (pmns). the histological inflammation score of the lungs in mice inoculated intratracheally with 10(8) cfu/mouse of the virulent strain s. constellatus rzyk001 obtained from bronchoalveolar fluid of a patient with pneumonia, was significantly higher than in mice inoculated with the avirulent strain ...19957745309
a mechanism of pathogenicity of "streptococcus milleri group" in pulmonary infection: synergy with an anaerobe.the relationship between streptococcus constellatus, one of the species of the "streptococcus milleri group", and prevotella intermedia was studied in a model of pneumonia in mice and in vitro to elucidate mechanisms of pathogenicity in "s. milleri group"-associated pulmonary infection. acute pneumonia with or without empyema and lung abscess in mice with mixed infection resulted in 60% mortality rate, but there was only 10% mortality and mild pneumonia in each separate infection. bacterial clea ...19948107060
intervertebral infection caused by streptococcus milleri. a case report.intervertebral infection caused by streptococcus milleri is described in a 45-year-old man. initially, a tuberculous infection was suspected; this diagnosis resulted in a considerable delay in correct diagnosis and treatment. the patient recovered well with combined medical-surgical treatment. streptococcus milleri, a common inhabitant of the gastrointestinal tract, comprises a variety of strains implicated in deep-seated purulent infections. although reports of this are rare, s. milleri can be ...19948168298
albumin-binding proteins on the surface of the streptococcus milleri group and characterization of the albumin receptor of streptococcus intermedius c5.members of the streptococcus milleri group (smg) that react with lancefield group c antisera were shown to bind large amounts of albumin although there was no direct relation between these two properties as polyclonal antisera to lancefield group c antigen did not prevent the binding of albumin. there was a specificity for albumin binding, with albumin from man, monkeys, cat, dog and mouse being bound to a greater degree than albumin from cow, horse, goat or rabbit. gold-labelled albumin was sho ...19938254315
phagocytosis of bacterial strains isolated from acute dentoalveolar abscess.the phagocytosis by human polymorphonuclear leucocytes of 37 bacterial strains identified as streptococcus milleri (10 strains), strictly anaerobic gram-positive cocci (10) prevotella intermedia (6), pr. oralis (5) and fusobacterium nucleatum (6) was investigated in vitro. the ingestion of s. milleri and strictly anaerobic gram-positive cocci was significantly greater (p < 0.001) than that of strains of prevotella spp. and f. nucleatum. the degree of uptake of capsulate and non-capsulate strains ...19938429541
[experimental studies of polymorphonuclear leukocyte on mandibular bone infection model in rabbit].polymorphonuclear leukocytes (pmn) play important roles in the prevention of infection at an early stage. we studied the function of these leukocytes using rabbit models of mandibular bone infection to evaluate the conditions which could not be reproduced in human beings streptococcus milleri nctc7331 and bacteroides fragillis nctc9343 were inoculated into the mandibular bone of rabbits using the satoh-heimdahl method, to produce supposed multiple infection models. rabbits inoculated with these ...19989642943
haemolytic activity of the streptococcus milleri group' and relationship between haemolysis restricted to human red blood cells and pathogenicity in s. intermedius.a collection of 297 clinically documented 'streptococcus milleri' strains, identified to the genotype level by 16s rrna gene hydridisation, was screened for haemolysis of human and animal red blood cells. forty-nine strains (65%) of the s. intermedius genotype displayed haemolysis restricted to human blood; they were named 'exclusive human haemolytic' (ehh) s. intermedius strains. the 26 remaining s. intermedius strains were named s. intermedius non-ehh strains. quantitative studies on the haemo ...200010628826
[meningitis and brain abscess caused by streptococcus intermedius in a patient infected with hiv-1].streptococcus milleri group have been recognized as an important pathogens for abscess formation in various organs. streptococci other than streptococcus pneumoniae are a rare cause of bacterial meningitis in adults and can be associated with the presence of an undiagnosed brain abscess. brain abscess is a focal collection within the brain parenchyma which can arise as a complication of a variety of infections. the most common etiologic organisms in clinical series have been microaerophilic stre ...200516011407
[a case of pulmonary abscess in which haemophilus parainfluenzae and streptococcus intermedius were isolated by percutaneous needle aspiration].some microbes, including the bacteroides species, staphylococcus aureus and streptococcus milleri groups, can cause pulmonary abscess. haemophilus parainfluenzae is usually categorized as one of the normal flora which colonizes in the ears and the nasopharynx, and it has been long considered that h. parainfluenzae has little pathogenicity in the lower respiratory tract and lung parenchymal. in this report, we present a case of pulmonary abscess caused by both h. parainfluenzae and streptococcus ...200616972613
[treatment of infected aortic arch aneurysm by in situ total arch replacement with omental wrapping; report of a case].we report a rare case of infected aortic arch aneurysm. 70-year-old man was admitted to our hospital for persistent high fever and blood culture demonstrated streptococcus milleri group. computed tomography revealed an aortic aneurysm. at the take off of the brachiocepharicartery. we performed a total aortic arch replacement with omental wrapping to prevent postoperative graft infection. the operative course was uneventful and discharged on postoperative day 65 with no signs of infection.200718018653
not all acute lower back pain is benign--paravertebral abscess and colonic cancer.low back pain with sciatica is one of the most common complaints of patients presenting to the ed, and it is usually managed on an outpatient basis. however, acute lower back pain not always derives from a benign cause. we report here the case of a 63-year-old diabetic man who presented to the ed complaining of acute low back pain with sciatica and fever. the cause was a large paravertebral abscess by streptococcus milleri, and this was the first presenting sign of an unknown underlying colonic ...200818410826
the cultural and biochemical characters of streptococcus milleri strains isolated from human sources.a collection of 346 strains of streptococcus milleri from a variety of human sources was examined culturally and biochemically, and for the presence of lancefield group antigens. most of the strains were non-haemolytic and ungroupable, but 25% were beta haemolytic and 19% were alpha haemolytic; 28% possessed a group antigen (a, 5%; c, 6%, f, 14%, g, 3%). these antigens were present in 69% of beta-haemolytic but in only 13% of alpha-haemolytic or non-haemolytic strains; beta haemolysis occurred i ...1979762404
osteoradionecrosis of the cervical spine complicated by pneumocephalus and meningitis in a nasopharyngeal cancer patient radically treated with radiotherapy 11 years ago.superimposed infection of osteoradionecrotic cervical spine with cranial extension is difficult to treat and potentially fatal. this report describes the case of a middle-aged chinese man 11 years post radical radiotherapy for nasopharyngeal cancer with no evidence of disease presenting initially with neck pain secondary to cervical osteoradionecrosis. he was re-admitted a month later with aspiration pneumonia associated with streptococcus milleri bacteraemia, complicated by septic shock. the la ...200921686429
lancefield group c streptococcus milleri group strains aggregate human platelets.lancefield group c streptococcus milleri group (smg) strains are the only smg types that are able to aggregate human platelets. complete aggregation occurred within 10 min of mixing bacterial cells and platelets together in the ratio 8:1. substances which (i) chelated cations; (ii) inhibited the cycloxygenase pathway in platelets; (iii) reduced the availability of adp and disrupted platelet membrane stability; (iv) reduced bacterial aggregation of platelets. the platelet-interacting substance on ...19947830532
the effects of aggregated human igg and igg-immune complexes on the agglutination of bacteria mediated by non-immunoglobulin salivary agglutinins.non-immunoglobulin salivary agglutinins (sba) for bacteria which bind to streptococcus milleri tj7 were isolated from parotid saliva and their interactions with human igg studied. purified sba showed a single band on sodium dodecyl sulphate-polyacrylamide gel electrophoresis with a molecular weight of approx. 500,000. heat aggregated human igg (63 degrees c, 30 min), but not native igg, interacted with sba and thereby interfered with the ability of the sba to agglutinate strep. milleri. immune c ...19873479095
emphysematous septic arthritis in multiple joints due to streptococcus milleri.a 26-year-old man with acute leukemia, treated with chemotherapy, developed emphysematous septic arthritis, due to streptococcus milleri, affecting the right knee and both shoulders. a review of the literature revealed that intraarticular gas formation is a rarely reported complication of septic arthritis. this could be the 2nd reported case of emphysematous septic arthritis due to s. milleri.19883164076
[taxonomic studies of the streptococcus intermedius strains isolated from human oral cavities].human oral isolates of streptococcus intermedius, which were biochemically identified, have been classified into 5-serogroups (i-v). selecting some representive stock cultures together with the type strain atcc 27335, comparisons were carried out between them in terms of cell extractable proteins, g + c mol% values, dna-dna homology and dna restriction fragments. since the taxon of s. intermedius has not been clarified, comparison was also made between the above strains and the type strains of t ...19892610299
beta-d-glucuronidase activity assay for rapid differentiation of species within beta-haemolytic group c and g streptococci.methylumbelliferyl-conjugated enzyme substrates were assessed for their ability to differentiate beta haemolytic streptococci in lancefield groups c and g. both streptococcus equisimilis (group c) and large colony human biotype group g strains were consistently differentiated from group c and g "streptococcus milleri group" bacteria by their ability to hydrolyse the beta-d-glucuronide substrate. the test was completed in less than one hour.19911960215
thoracic empyema due to streptococcus intermedius.with improved laboratory identification procedures, streptococcus milleri (intermedius) is becoming recognized as an important human pathogen with the potential to form abscesses in a wide range of organs. the occurrence of a rapidly progressive and toxic empyema due to this organism in an otherwise healthy young adult without a predisposing lower respiratory tract infection allows us to examine the possibility that this microbe may be a significant but frequently unrecognized cause of adult emp ...19911748832
differentiation of species in human beta-haemolytic group g streptococci using immunoglobulin fc fragment assess the ability of human immunoglobulin fc fragment binding activity to differentiate human biotype large colony group g streptococci from the group g "streptococcus milleri group".19921556232
an infected abdominal aortic aneurysm and hepatic abscesses due to streptococcus milleri.the case of a 78 year old man who presented with fever and hepatic abscesses is reported. he was found to have an infected abdominal aortic aneurysm and the organism cultured was streptococcus milleri. he was treated with an in situ dacron graft and high-dose intravenous penicillin. this may be suitable treatment when gram-positive organisms are involved and there is no gross peritoneal soiling.199220169713
[saprophytic pleuritis with candida parapsilosis].a 73-year-old man was admitted to our hospital with pneumonia in the right s6 induced by streptococcus milleri and with left pleural thickening. he had histories of diabetes mellitus for 30 years and pulmonary tuberculosis 35 years ago. the pneumonia resolved completely after administration of ceftazidime and clindamycin for 10 days, but the pleural thickening remained and computed tomography revealed that it was an encapsulated effusion without calcification. an aspirate was turbid yellow with ...19968778477
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