adjuvant properties of micropolyspora faeni.the adjuvant properties of micropolyspora faeni, an important source of antigenic material in the production of farmer's lung, were evaluated by comparing antibody- and cell-mediated immune responses of rabbits to bovine serum albumin (bsa) incorporated in complete freund's adjuvant (cfa), incomplete freund's adjuvant (ifa) and incomplete freund's adjuvant with 5-10 mg/ml homogenized m. faeni (mfa). rabbits immunized with bsa in cfa or mfa developed significantly increased antigen-induced macrop ...1977338504
mitogenicity of cell wall fractions of micropolyspora faeni.cell wall fractions of micropolyspora faeni, a causative agent of hypersensitivity pneumonitis, have been shown to possess non-specific mitogenic activity for guinea pig, rabbit and human lymphocytes. this activity was unrelated to endotoxin and may not be associated with peptidoglycan. this lymphocyte proliferation stimulus may play a role in the adjuvant properties of this organism and in the etiology of hypersensitivity lung disease.1978623390
isolation of lipopolysaccharide from the walls of micropolyspora faeni: chemical composition and serological reactivity.extraction of mycelium or walls of micropolyspora faeni with cold or hot aqueous phenol yielded a lipopolysaccharide consisting of lipid a, phosphate, galactose, arabinose, glucose, glucosamine, and a dideoxy sugar. extraction with trichloroacetic acid (tca) yielded an incomplete molecule lacking lipid a. part of an o-chain was secreted into the culture medium. phenol and tca extracts gave three lines of precipitation with human serum from cases of farmer's lung disease, and one of these was giv ...1975803548
[the serial changes of antibody production, macrophage migration inhibition test (mit) and histopathologic examination in an experimental hypersensitivity pneumonitis in rabbits].we developed a hypersensitivity pneumonitis model by sensitizing rabbits intratracheally (it) twice after two subcutaneous sensitizations (ss), and investigated the serial changes in the production of antibody against micropolyspora faeni (mf), macrophage migration inhibition test (mit), and histopathologic features. on the third day after the last it, the proportions of neutrophils in bronchoalveolar lavage fluid (balf) increased. the antibody levels of mf specific-antigen in balf decreased tra ...19902355672
"haysickness" in icelandic horses: precipitin tests and other studies.blood samples were taken from 18 healthy horses (group a), 15 horses clinically diagnosed to have "haysickness" ("farmer's lung") (group b), 10 closely related horses (group c) and 14 inbred horses (group d). precipitins in sera were measured by double gel diffusion test against micropolyspora faeni, thermoactinomyces vulgaris, aspergillus fumigatus, alternaria, penicillium and rhizopus species. in group a, all the horses were precipitin negative except one with a faint reaction to rhizopus spec ...19836411460
viral infection enhances lung response to micropolyspora faeni.farmer's lung is an important form of hypersensitivity pneumonitis. it is believed to represent a delayed type allergic reaction to microorganisms found in moldy hay dust. the disease is prevalent in farmers from countries where, because of high humidity in the summer, molding of stored hay is unavoidable.19948116658
modulation of experimental hypersensitivity pneumonitis by sendai evaluate the potential role of viruses in the pathogenesis of hypersensitivity pneumonitis (hp), we looked at the effect of challenging normal versus sendai-injected mice with saccharopolyspora rectivirgula (sr). in this model of hp, mice are nasally instilled with sr antigen three consecutive days per week of study. for this study virus was given after 3 weeks of sr. two positive (sr alone, virus alone) and a negative (saline) control groups were done in parallel with the viral plus sr group ...19938386739
serum kl-6 concentrations in dairy farmers.serum kl-6 (krebs von den lungen-6) has been recognized to be a marker for the activity of diffuse interstitial lung diseases. the purpose of the study is to evaluate serum kl-6 measurement as a marker for farmer's lung disease (fld).200010936139
cd34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.rationale: although recent work has shown that cd34 plays an important role in the trafficking of inflammatory cells during th2-biased inflammatory responses, its role in th1/th17-biased disease as well as dendritic cell (dc) trafficking is unknown. objectives: we used cd34-deficient mice (cd34-/-) to investigate the role of cd34 in the th1/th17-biased lung inflammatory disease, hypersensitivity pneumonitis (hp). methods: hp was induced in wild type and cd34-/- mice by repeated intranasal admini ...201121642249
antibody-independent complement consumption by micropolyspora faeni.micropolyspora faeni is an etiologic agent of hypersensitivity pneumonitis, a disease with an ill-defined mechanism of pathogenesis. many reports have suggested an immunologic mechanism. a number of laboratories have demonstrated a nonantibody-mediated activation of the complement cascade. this study was undertaken to define the pathway of the complement consumption induced by m. faeni. we utilized an extract of m. faeni grown on synthetic media rather than the more common double dialysis extrac ...19806768678
transforming growth factor-beta is generated in the course of hypersensitivity pneumonitis: contribution to collagen synthesis.mice of the c57bl/6 strain were instilled with optimal doses (150 micrograms/day for 3 days/wk) of the thermophilic actinomycete faeni rectivirgula (also known as saccharopolyspora rectivirgula or micropolyspora faeni) to induce a hypersensitivity pneumonitis inflammation that mimics the human disease affecting certain occupational groups. this mouse model was characterized by a very significant alveolitis (3-fold increase in bronchoalveolar lavage [bal] cell number at 48 h and a 10-fold increas ...19921497904
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