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endogenous intraocular nocardia asteroides in hodgkin's disease.a 60-year-old man receiving antituberculous and corticosteroid therapy for a granulomatous disease of uncertain etiology was found to have a chorioretinal mass in his right eye. fluorescein angiography showed blockage of fluorescence by the mass and late leakage. autopsy findings were compatible with hodgkin's disease with disseminated nocardiosis caused by nocardia asteroides. organisms typical of nocardia were found in the choroid and subretinal space. the patient's history, ophthalmic examina ...1978362928
human pulmonary nocardiosis.the involvement of nocardia species in human pulmonary infections was investigated. pulmonary nocardiosis mimics pulmonary tuberculosis in both clinical symptoms and radiological characteristics. in third world countries where diagnosis is based solely on such findings, anti-tuberculosis regimens may indicate chronic tuberculosis when in fact pulmonary nocardiosis should have been treated. differential diagnosis is recommended for efficient health care and cost-effective drug use.19921593965
mycobacterial and nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus infection: a prospective, cohort study.a prospective observational study was done to describe nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus (hiv) infection.200111602023
posttraumatic exogenous nocardia endophthalmitis.to report a case of posttraumatic exogenous nocardia endophthalmitis.200312788146
head actinomycetoma with a double aetiology, caused by nocardia brasiliensis and n. asteroides.we describe a 64-year-old man with an actinomycetoma of the frontal region of the head caused simultaneously by two aetiological agents, nocardia brasiliensis and n. asteroides. this case is presented due to the unusual body site affected and, above all, because two aetiological agents were isolated.200010886160
[nocardiosis in patients with human immunodeficiency virus infection in spain].nocardia usually infects immunosuppressed patients, particularly with cellular immunity deficiency. nevertheless, despite severe immunosuppression in patients infected with hiv, nocardiosis is rare among these patients. we report here two cases of nocardiosis in patients with hiv infection and review spanish literature up to 1993, with an analysis of the characteristics of this infection in our country.19957667522
effects of human neutrophils and monocytes on nocardia asteroides: failure of killing despite occurrence of the oxidative metabolic burst.to study mechanisms of resistance to nocardia asteroides in vitro, suspensions of human neutrophils and monocytes were challenged with n. asteroides in the presence of autologous serum. at 4 hr, numbers of viable n. asteroides incubated with neutrophils and monocytes averaged only 10% and 21% less, respectively, than numbers of n. asteroides incubated without phagocytes. in contrast, a mean of > 90% of listeria monocytogenes and staphylococcus aureus incubated with neutrophils and monocytes was ...19806777435
[cutaneous nocardiosis as an opportunistic infection].a 46-year-old man who had been treated with azathioprine and budesonide for crohn's disease for the past eight years developed a purulent skin condition on the right ring finger. despite surgical drainage and treatment with amoxicillin and flucloxacillin, the condition spread itself over the hand and lower arm, partly per continuum and partly in jumps. the patient did not feel ill and there were no systemic symptoms. ultimately, nocardia asteroides was cultured from the wound and complete cure w ...200415054953
nocardial osteomyelitis of the spine with epidural spinal cord compression--a case report.a 53-year-old man presented with complaints of back pain and weakness in his lower extremities. physical examination demonstrated a thoracic myelopathy with a sensory level at t-4. the diagnostic work-up revealed vertebral osteomyelitis of the thoracic spine with epidural compression at t-2-t-4 causing a nearly complete block on myelography. a decompressive laminectomy and debridement were performed, followed by anterior spinal fusion. nocardia asteroides was cultured from the epidural space. th ...19846384811
[human nocardia asteroides infection: apropos of 5 cases]. 19846369019
nocardia asteroides aortitis with perforation of the aorta.a 53-year-old man died of nocardial aortitis eight months after undergoing aortic valve replacement. autopsy revealed vegetation in the area of a previous aortotomy incision and a small perforation of the aorta enclosed by pericardium immediately above the prosthetic valve ring. prosthetic valve endocarditis was not present. multiple splenic infarcts, microabscesses of both kidneys, and myocarditis were identified. antemortem blood cultures and postmortem cultures of the aortic vegetation grew n ...19853891578
[nocardia brain abscess and ventriculitis--resistance of nocardia to sulfonamides and susceptibility to beta-lactams].a 31-year-old man had been healthy until the end of august, 1984 when he developed a sore throat, rhinorrhea, and high fever (39 degrees c). he was found to have hematuria and leukocytosis, though his complaints were not severe, and was not absent from his work. from the september 30, he experienced continuous pains on both temple regions and the neck. on october 6, he visited our hospital without any inflammatory signs. a screening ct scan demonstrated a ring-like enhancing mass with remarkable ...19863703132
[bronchopneumonia due to nocardia asteroides in a man with chronic obstructive pulmonary disease]. 200516324608
lymphocutaneous nocardiosis caused by nocardia asteroides. case report and literature review.a 22-year-old man developed erythematous nodules and an ulcer mimicking sporotrichosis on his right hand and forearm, which was subsequently diagnosed as lymphocutaneous nocardiosis caused by nocardia asteroides. to our knowledge, 21 cases of lymphocutaneous nocardiosis have been reported, with the majority of those cases, except for a few that remain uncertain, being due to nocardia brasiliensis. the case reported herein, the first known definitive case caused by n asteroides (to our knowledge) ...19863532961
isolation and some properties of beta-hemolysin produced by nocardia asteroides.an intracellular beta-hemolysin capable of lysing human, sheep and cow erythrocytes but not cells from some other animals was isolated from the cell walls of the three developmental cell-forms of nocardia asteroides and characterised. the spherical cell-forms contained the highest amounts of the hemolysin (100 h.u./mg protein) and the least ld50 for mice suggesting that this may be the cell-form most pathogenic to susceptible animals. the hemolysin has the properties of a protein, was ph stable ...19863531870
nocardia asteroides strain guh-2 induces proteasome inhibition and apoptotic death of cultured cells.many bacterial pathogens have the ability to induce apoptosis in their hosts. it was previously shown that nocardia asteroides strain guh-2, a gram-positive facultatively intracellular pathogen, is capable of inducing the apoptotic death of dopaminergic cells in the murine brain and in pc12 cells, a rat cell line. in this study, the apoptosis-inducing potential of n. asteroides guh-2 was further explored using hela cells, a human epithelial cell line. hela cells were incubated for 5h with live n ...200717258894
chest wall dissemination of nocardiosis after percutaneous transthoracic needle biopsy.we described a case of chest wall dissemination after percutaneous transthoracic needle biopsy. a 65-year-old man had a lung nodule which was suspected to be lung carcinoma. he underwent percutaneous transthoracic needle biopsy using an 18g semiautomated biopsy needle and pathologic diagnosis showed organizing pneumonia. two months after the biopsy, chest wall dissemination occurred. implantation of carcinoma along the biopsy route was suspected, but the mass was actually due to pulmonary nocard ...200717659426
case records of the massachusetts general hospital. weekly clinicopathological exercises. case 18-1988. a 30-year-old man with bilateral pulmonary consolidation and cavitation. 19883283550
[primary cutaneous nocardiosis and human immunodeficiency virus infection]. 19892666775
pleurocerebral nocardia in a patient with human immunodeficiency virus.to report a case of nocardia asteroides pneumonia and subsequent brain abscess in an immunocompromised host.19921554928
nocardia choroidal abscess.nocardia is a gram positive, aerobic, filamentous branching micro-organism that rarely causes human infection. when infection does occur it usually takes the form of a subcutaneous abscess or a pneumonia-like illness. we describe a case of a patient with chronic lymphocytic leukaemia who developed painless loss of vision in the right eye secondary to a choroidal abscess after a prolonged course of treatment on several immunosuppressive agents. the patient also complained of right shoulder pain t ...19921477051
an elderly man with nonresolving cough, leukocytosis and a pulmonary mass. 200312874165
intralobar and extralobar bronchopulmonary sequestration complicated by nocardia asteroides infection.pulmonary sequestration is a rare congenital or acquired pulmonary anomaly. pulmonary sequestration may be classified as intralobar, located within normal lung, or extralobar, in which it is separated by pleura. the coexistence of both forms is extremely rare. infection, mainly bacterial, is a major complication of sequestration. we report the case of a young man in whom a sequestration with both intralobar and extralobar components was complicated by nocardia asteroides infection.200312602723
pulmonary nocardiosis in a patient treated with corticosteroid therapy.we report a case of pulmonary nocardiosis in a 69-year-old man with rheumatoid arthritis who was receiving corticosteroid treatment. the patient received prednisolone for rheumatoid arthritis and antibiotics for his fever and pneumonia in another hospital, but the response to the therapy was poor. after admission to our hospital, he improved following treatment with imipenem/cilastatin for nocardia asteroides. pulmonary nocardiosis is difficult to diagnose and should be considered in the differe ...200211915862
complications associated with silicone intracanalicular plugs.to assess american society of ophthalmic plastic and reconstructive surgery (asoprs) member physicians' experiences with complications associated with silicone intracanalicular plugs and publicize risks associated with this device.200111766032
cavitary lung disease in aids: etiologies and correlation with immune status.to investigate the etiology and differential features of cavitary lung disease in patients with acquired immune deficiency syndrome (aids), chest computed tomography (ct) records from a 2-year period were reviewed to identify all human immunodeficiency virus (hiv)-positive patients with cavitary lung disease. medical records were reviewed for the documentation of specific causes of lung cavitation and the cd4 count at the time of imaging. of 25 hiv-positive patients with cavitary lung disease, 2 ...200111483162
nocardia asteroides native valve endocarditis.a 39-year-old man with a history of injection drug abuse was given a diagnosis of nocardia asteroides native aortic valve endocarditis, and he required valve replacement therapy, despite having received potent antimicrobial therapy. this is the first reported proven case of native valve endocarditis due to nocardia species.200111181135
chronic granulomatous pleuritis caused by nocardia: pcr based diagnosis by nocardial 16s rdna in pathological specimens.nocardiosis is an uncommon infection caused by the aerobic actinomycete nocardia. identification of the pathogen is essential for the definitive diagnosis and for an effective treatment. this report describes a case of chronic granulomatous pleuritis caused by nocardia. a 59 year old japanese man had a history of repeated pyothorax. right pleural decortication and thoracic drainage were performed. microbiological examinations of the drained fluid failed to identify a pathogen. pathological exami ...200314645361
phaeohyphomycosis from exphiala jeanselmei with concomitant nocardia asteroides infection in a renal transplant recipient: case report and review of the literature.a 59-year-old black man who received a cadaveric renal transplant 15 months earlier developed subcutaneous nodules on his right upper extremity that were identified as phaeohyphomycosis caused by exophiala jeanselmei. the man was admitted 4 weeks later with a swollen left arm and had nocardia asteroides in this area and in the apex of his left lung. he was treated with surgical excision, and itraconazole, imipenem-cilastatin, and trimethoprim-sulfamethoxazole. with the potential presence of more ...199910453973
[pulmonary nocardiosis associated with cushing's syndrome].a 54-year-old man was admitted for further investigation of multiple nodules disclosed by a chest roentgenogram. adrenocorticotropic hormone (acth)-dependent cushing's syndrome was diagnosed because serum acth and serum cortisol levels were elevated with a loss of diurnal rhythm. because several extensive examinations, including inferior petrosal sinus sampling, did not detest acth-producing tumors, the patient was also given a diagnosis of occult ectopic acth syndrome. the nodules disclosed on ...199910214041
[other infections (streptococcus pneumoniae, haemophilus influenzae, pseudomonas aeruginosa, salmonella spp., campylobacter spp., nocardia asteroides, rhodococcus equi and bartonella spp.)].people infected with human immunodeficiency virus (hiv) are at increased risk for bacterial infections due to hiv-associated immunologic defects. bacterial infections were found to be, both a predictor of progression to aids and a substantial cause of mortality in pre-aids stages. most bacterial infections are caused by streptococcus pneumoniae, haemophilus influenzae, salmonella spp. and pseudomonas aeruginosa. rhodococcus equi, nocardia spp., campylobacter spp. and bartonella spp. are less com ...19989859621
nocardia asteroides peritonitis in a patient with cirrhosis and human immunodeficiency virus infection. 19948086531
in situ hybridization for detection of nocardial 16s rrna: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in lewy body-containing human brain specimens.our previous studies found that experimental infection of balb/c mice with the gram-positive bacterium nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (sn) with an appearance similar to lewy bodies. in the present study, an in situ hybridization technique was developed to detect nocardial 16s ribosomal rna (rrna ...200314769363
exogenous nocardia asteroides endophthalmitis associated with malignant glaucoma.a 42-year-old man sustained a penetrating corneal wound with a soil-contaminated wire and developed nocardia asteroides endophthalmitis. a month delay in diagnosis occurred while topical and systemic steroids were prescribed for persistent anterior uveitis, but the diagnosis was finally established by separate aqueous and vitreous aspirates. the patient's course was complicated by a form of malignant glaucoma that was relieved by vitreous aspiration and reformation of the anterior chamber. surgi ...19817020550
nocardia keratitis in a human immunodeficiency virus patient.the development of nocardia keratitis in a patient with human immunodeficiency virus infection is rare, and we could find no cases reported in the literature.200415175921
concurrent sino-orbital aspergillosis and cerebral nocardiosis.a 79-year-old man with myelodysplastic syndrome developed a right optic neuropathy with optic disc edema and intractable periocular pain, one month after undergoing removal of a gangrenous gallbladder. although results of a temporal artery biopsy were negative, he was treated with prednisone for presumed temporal arteritis. attempts at tapering the prednisone dose led to recurrence of periocular pain. on neuro-ophthalmologic evaluation six months after the prednisone treatment was begun, he had ...200415179067
[necrotizing lymphadenitis caused by nocardia asteroides in a healthy girl].a case of a healthy girl with a trauma in her right leg is described. twelve hours later she developed fever and pain in the inguinal region. two days later, she was admitted to the hospital, and there, an aspiration of pus from the lymph node was performed, and this sample was sent for culture. the gram smear showed gram-positive filamentous bacilli and when kinyoun was used they were observed as weakly acid fast rods. after four days of incubation under aerobic conditions, white and hemolitic ...200415470865
[nocardiosis in patients with human immunodeficiency virus infection].nocardiosis is a bacterial disease that occurs in immunocompromised patients, including those infected by the human immunodeficiency virus (hiv).200516159542
nocardia abscess during treatment of brain toxoplasmosis in a patient with aids, utility of proton mr spectroscopy and diffusion-weighted imaging in diagnosis.we report the case of a 30-year-old man with known hiv-positive status who developed, 4 months prior to admission, recurrent left partial motor seizures followed by left hemiparesis. at another hospital, contrasted ct scan of the head revealed right frontal hypodense lesion with mass effect and focal contrast enhancement. a small left occipital lesion was also present. hiv-associated brain toxoplasmosis was considered and phenytoin, pyrimethamine, clindamycin and antiretrovirals were administere ...200616720224
pulmonary nocardiosis: an unusual cause of a solitary pulmonary nodule.nocardiosis is an infection caused by a soil-borne aerobic micro-organism. the pathogen is most commonly introduced in humans by inhalation into the respiratory tract. this infection may be transient and subclinical or may result in an acute or chronic bronchopulmonary process. although an unusual cause of pulmonary infection in immunocompentent individuals, human nocardiosis is now documented more often in patients whose cell-mediated immunity is compromised by immunosuppression from comorbid d ...200616734042
[a case of pulmonary nocardiosis diagnosed five years after hemoptysis].a 73-year-old man complaining of bloody sputum was admitted to our hospital in august 2000. his giant left lower lung field bulla had been removed in 1997, at which time atelectasis in left s10 was pointed out. production of bloody sputum was stopped by the emergency bronchial artery embolization, and nocardia species was found in the sputum. because of both spontaneous disappearance of nocardia species and no evidence of nocardia infection, he was followed carefully by chest radiography every f ...200718186241
middle cerebral artery aneurysm due to nocardia asteroides: case report of aneurysm excision and extracranial-intracranial bypass.nocardia asteroides is an uncommon human pathogen typically encountered in immunocompromised patients. primary central nervous system (cns) nocardiosis is rare and usually manifests as cerebritis or abscesses. the case of a young woman who presented with cns nocardia abscesses complicated by an infective middle cerebral artery aneurysm is reported. treatment, which included abscess aspiration, aneurysm excision, and end-to-end extracranial to intracranial bypass and prolonged antibiotic therapy, ...19883288900
nocardiosis at the turn of the century.nocardia species is an uncommon pathogen that affects both immunosuppressed and immunocompetent patients. the clinical and microbiologic spectrum of nocardiosis has changed recently due to the widespread use of cotrimoxazole prophylaxis, the emergence of new types of immunosuppressed patients, and the improved identification of isolates using molecular techniques. nocardia asteroides was traditionally considered the predominant organism, and prophylaxis with cotrimoxazole was considered almost u ...200919593231
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