Publications

succinyl-coa:3-ketoacid coa transferase (scot): cloning of the human scot gene, tertiary structural modeling of the human scot monomer, and characterization of three pathogenic mutations.	the activity of succinyl-coa:3-ketoacid coa transferase (scot; locus symbol oxct; ec 2.8.3.5) is the main determinant of the ketolytic capacity of tissues. hereditary scot deficiency causes episodic ketoacidosis. here we describe the human scot gene, which spans more than 100 kb and contains 17 exons, on chromosome 5p13. we report pathogenic missense mutations in three scot-deficient patients designated gs04, 05, and 06. gs04 is a g219e/g324e compound; gs05 is a v221m homozygote, and gs06 is a g ...	2000	10964512
comparative in vitro activities of ertapenem (mk-0826) against 1,001 anaerobes isolated from human intra-abdominal infections.	by using an agar dilution method, the comparative in vitro activities of ertapenem (mk-0826) were studied against 1,001 anaerobes isolated from human intra-abdominal infections in 17 countries worldwide. mk-0826 was uniformly active against all isolates, including all bacteroides fragilis group species isolates, with the exception of 12 of 61 (20%) strains of bilophila wadsworthia, 3 strains of lactobacilli, and 1 isolate of acidaminococcus fermentans. geographical variation in activity was not ...	2000	10952584