inhibition of acid secretion from parietal cells by non-human-infecting helicobacter species: a factor in colonization of gastric mucosa?helicobacter pylori has been shown to produce a protein that inhibits acid secretion from parietal cells. we have examined other non-human-infecting helicobacter species for this property by measuring the uptake of [14c]aminopyrine into rabbit parietal cells as an indirect assessment of acid secretion. helicobacter felis and an isolate from a rhesus monkey were shown to inhibit acid secretion. isolates of helicobacter mustelae gave variable responses. whole bacteria and cell-free sonicates impai ...19911894369
experimental infection of rhesus monkeys with a human strain of campylobacter jejuni.young rhesus monkeys (macaca mulatta) were infected orally with a human strain of campylobacter jejuni. the disease induced was mild, with inappetence and diarrhoea of short duration, but prolonged intermittent excretion of the bacteria in the faeces occurred. bacteraemia was generally present for 2--3 days and later the organisms localized in the liver and gall bladder. recovered animals, when challenged with the same strain, showed no clinical symptoms, no bacteraemia, and excreted the organis ...19817016990
arcobacter (campylobacter) butzleri-associated diarrheal illness in a nonhuman primate population.after dna hybridization identified an isolate from an ill rhesus macaque (macaca mulatta) as arcobacter (campylobacter) butzleri, we initiated a study to determine whether a. butzleri was associated with diarrheal disease in nonhuman primates at the yerkes primate research center. by using campy-cva medium incubated at 35 degrees c, 15 a. butzleri isolates were obtained from 14 macaques; 7 macaques were coinfected with campylobacter coli and campylobacter jejuni. a. butzleri was not isolated fro ...19938478115
antimicrobial resistance and plasmid profiles of campylobacter jejuni and campylobacter coli from human and animal sources.the purpose of this study was to determine the susceptibility of campylobacter jejuni and campylobacter coli isolates to antimicrobial agents and to investigate the presence of plasmid dna.200211849513
detection of campylobacter jejuni in healthy monkeys and monkeys with enteric infections by pcr.campylobacter were detected by pcr in feces of monkeys of different species (clinically healthy, with diarrhea, and dead from acute enteric infections). high prevalence of these bacteria in monkeys was revealed. the incidence of c. jejuni dna in monkeys with acute enteric infections was higher than in healthy animals (69.6 and 51.3%, respectively). the highest percentage (92.3) of positive results was observed in macaca mulatta with enteric diseases and in macaque dead of these diseases. the pre ...200212512007
establishment of a non-human primate campylobacter disease model for the pre-clinical evaluation of campylobacter vaccine formulations.campylobacter jejuni is a common cause of enteritis worldwide. the mechanisms by which c. jejuni causes disease are unclear. challenge studies in humans are currently considered unethical due to the possibility of severe complications, such as guillain-barré syndrome. campylobacter infection in non-human primates closely mimics the disease and immune response, seen in humans. in this study, we attempted to determine the minimal dose of a pathogenic c. jejuni 81-176 strain required for clinical s ...200616098634
infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques.chronic enterocolitis is the leading cause of morbidity in colonies of captive rhesus macaques (macaca mulatta). this study's aim was to identify the common enteric pathogens frequently associated with chronic enterocolitis in normal, immunocompetent rhesus monkeys and to elucidate the influence of this clinical syndrome on the host immune system. we analyzed the fecal specimens from 100 rhesus macaques with or without clinical symptoms of chronic diarrhea. retrospective analysis revealed an inc ...200312819098
early colonic damage and invasion of campylobacter jejuni in experimentally challenged infant macaca mulatta.experimental challenge studies with campylobacter jejuni were conducted in 3.5-month-old infant macaca mulatta. one infant monkey (92-1) was challenged with 2.7 x 10(10) cfu of strain 78-37. a second infant was infected intentionally by natural transmission. the infants developed diarrhea 32 h after challenge of infant 92-1. electron microscopic observations indicate that cell invasion is the primary mechanism of colon damage and diarrheal disease caused by c. jejuni. intracellular c. jejuni wer ...19938515112
safety and immunogenicity of a prototype oral whole-cell killed campylobacter vaccine administered with a mucosal adjuvant in non-human primates.the safety and immunogenicity of two prototype oral campylobacter killed whole-cell (cwc) vaccines were tested in rhesus monkeys. animals were immunized with a primary two-dose series (days 0 and 14) of vaccine consisting of cwc (10(10) particles/dose) given alone or in combination with 0.5-1000 micrograms of the heat-labile enterotoxin of escherichia coli as an oral adjuvant (oa). a booster vaccination, 4 weeks after primary immunization, was given to animals receiving cwc alone or supplemented ...19957539199
isolation of campylobacter jejuni from experimental dogs and monkeys in japan.isolation of campylobacter jejuni (c. jejuni) from experimental dogs and monkeys was undertaken. c. jejuni was detected from 14.7% of the fecal samples obtained from beagles in a production colony, whereas 32% of newly imported beagles harbored the organisms. c. jejuni was isolated from 25% of the young and 3.9% of adult dogs in an animal center. the organisms were isolated from newly imported cynomolgus and rhesus monkeys at high frequencies (49.2% and 38.8%, respectively). almost all of the st ...19846468516
serologic host response to helicobacter pylori and campylobacter jejuni in socially housed rhesus macaques (macaca mulatta). 201222920270
isolation of a gastric campylobacter-like organism from the stomach of four rhesus monkeys, and identification as campylobacter pylori.campylobacter-like organisms, isolated from the gastric antrum of rhesus monkeys, were compared with campylobacter jejuni and c. pylori. they were similar to c. pylori by light microscopy, in ultrastructural morphology, in enzymic, fatty-acid-methyl-ester, and protein-profile analysis, and in antigenic reactivity with rabbit antisera to c. jejuni and c. pylori and with c. pylori-specific monoclonal antibody. because this natural infection of the rhesus monkey is associated with chronic gastritis ...19883172170
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