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immunization with plasmid dna encoding the hemagglutinin and the nucleoprotein confers robust protection against a lethal canine distemper virus challenge.we have investigated the protective effect of immunization of a highly susceptible natural host of canine distemper virus (cdv) with dna plasmids encoding the viral nucleoprotein (n) and hemagglutinin (h). the combined intradermal and intramuscular routes of immunization elicited high virus-neutralizing serum antibody titres in mink (mustela vison). to mimic natural exposure, we also conducted challenge infection by horizontal transmission from infected contact animals. other groups received a l ...200415315843
serologic survey for selected viral pathogens in free-ranging endangered european mink (mustela lutreola) and other mustelids from south-western france.to investigate the possible role of selected pathogens in the decline of endangered european mink (mustela lutreola) populations and the potential for these pathogens to affect mink survival, a serologic survey was conducted using serum samples collected from march 1996 to march 2003 in eight departments of south-western france. in total, 481 free-ranging individuals of five mustelid species (including the european mink) were tested. sympatric mustelids can serve as sentinels to determine the pr ...200818957635
pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks.canine distemper virus (cdv) infects a broad range of carnivores and causes a highly contagious disease with severe immunosuppression. the disease severity markedly varies in different species. to investigate the pathogenesis of cdv in raccoon dog (nyctereutes procyonoides), fox (vulpes vulpes) and mink (neovison vison) species, three groups of cdv sero-negative animals were infected with cdv strain ln(10)1. this cdv strain belongs to the asia-1 genotype, which is epidemiologically predominant i ...201526210812
invasive american mink: linking pathogen risk between domestic and endangered carnivores.infectious diseases, in particular canine distemper virus (cdv), are an important threat to the viability of wild carnivore populations. cdv is thought to be transmitted by direct contact between individuals; therefore, the study of species interactions plays a pivotal role in understanding cdv transmission dynamics. however, cdv often appears to move between populations that are ecologically isolated, possibly through bridge hosts that interact with both species. this study investigated how an ...201424604545
wildlife reservoirs of canine distemper virus resulted in a major outbreak in danish farmed mink (neovison vison).a major outbreak of canine distemper virus (cdv) in danish farmed mink (neovison vison) started in the late summer period of 2012. at the same time, a high number of diseased and dead wildlife species such as foxes, raccoon dogs, and ferrets were observed. to track the origin of the outbreak virus full-length sequencing of the receptor binding surface protein hemagglutinin (h) was performed on 26 cdv's collected from mink and 10 cdv's collected from wildlife species. subsequent phylogenetic anal ...201424454897
dna vaccines encoding proteins from wild-type and attenuated canine distemper virus protect equally well against wild-type virus challenge.immunity induced by dna vaccines containing the hemagglutinin (h) and nucleoprotein (n) genes of wild-type and attenuated canine distemper virus (cdv) was investigated in mink (mustela vison), a highly susceptible natural host of cdv. all dna-immunized mink seroconverted, and significant levels of virus-neutralizing (vn) antibodies were present on the day of challenge with wild-type cdv. the dna vaccines also primed the cell-mediated memory responses, as indicated by an early increase in the num ...201222714870
transcript profiling of toll-like receptor mrnas in selected tissues of mink (neovison vison).toll-like receptors (tlrs) can recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses against invading infectious agents. the aim of this study was to assess the transcript profile of mink tlrs (mtlrs) in mink peripheral blood mononuclear cells (pbmcs) and a range of tissues, and to explore the potential role of mtlrs in the antiviral immune response process. the results indicated that the mtlr partial nucleotide sequences had a high degree of nu ...201627435536
canine distemper epizootic in everglades mink.four free-ranging mink, neovison vison, collected between june and september 2004 in the fakahatchee strand preserve state park (fspsp, florida, usa), were examined for canine distemper virus (cdv) infection. microscopic lesions and viral inclusions consistent with cdv infection were observed in three mink. virus isolation and reverse transcription-polymerase chain reaction performed on all mink were positive for cdv. anecdotal records of mink observations in fspsp suggest a postepizootic declin ...200919901388
serology and protein electrophoresis for evidence of exposure to 12 mink pathogens in free-ranging american mink (neovison vison) in argentina.basic pathologic characteristics for farmed minks were previously reported worldwide. however, its status in the wild has not been studied in detail.201728635524
naturally occurring influenza a virus subtype h1n2 infection in a midwest united states mink (mustela vison) ranch.influenza a virus (fluav) causes acute respiratory disease in humans and a variety of animal species. the virus tends to remain within the species of origin; nonetheless, naturally occurring cross-species transmission of fluav has been periodically documented. multiple cross-species transmissions of fluav have been reported from companion animals and captive wild animals, neither of which is historically considered as natural hosts of fluav. in the fall of 2010, mink (mustela vison) inhabiting a ...201122362526
aleutian disease serology, protein electrophoresis, and pathology of the european mink (mustela lutreola) from navarra, spain.the european mink, mustela lutreola, has suffered a dramatic decline in europe during the 20th century and is one of the most endangered carnivores in the world. the subpopulation of european mink from navarra, spain, estimated to number approximately 420, represents approximately two thirds of the total number of mink in spain. aleutian disease virus (adv) is a parvovirus with a high degree of variability that can infect a broad range of mustelid hosts. the pathogenesis of this virus in small c ...200818816991
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