Publications

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effective, broad spectrum control of virulent bacterial infections using cationic dna liposome complexes combined with bacterial antigens.protection against virulent pathogens that cause acute, fatal disease is often hampered by development of microbial resistance to traditional chemotherapeutics. further, most successful pathogens possess an array of immune evasion strategies to avoid detection and elimination by the host. development of novel, immunomodulatory prophylaxes that target the host immune system, rather than the invading microbe, could serve as effective alternatives to traditional chemotherapies. here we describe the ...201020523903
frequency of detection of immunoglobulins of toxoplasma gondii, leptospira spp., and brucella abortus in livestock/farm and abattoir workers in trinidad.toxoplasma gondi, leptospira spp., and brucella abortus are all established parasitic and bacterial zoonoses that manifest themselves in several forms of human diseases. they have been associated with occupational exposures, particularly amongst workers associated with livestock farms. the primary objectives of this study were to determine the seroprevalence of t. gondii immunoglobulin m (igm) immunoglobulins (serum antibodies), leptospira igm immunoglobulins, and b. abortus igg immunoglobulins, ...201121728871
brucella abortus inhibits ifn-γ-induced fcγri expression and fcγri-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages.the strategies that allow brucella abortus to persist for years inside macrophages subverting host immune responses are not completely understood. immunity against this bacterium relies on the capacity of ifn-γ to activate macrophages, endowing them with the ability to destroy intracellular bacteria. we report here that infection with b. abortus down-modulates the expression of the type i receptor for the fc portion of igg (fcγri, cd64) and fcγri-restricted phagocytosis regulated by ifn-γ in hum ...201021070860
serological survey of pre-weaned new zealand fur seals (arctocephalus forsteri) for brucellosis and leptospirosis.to conduct a longitudinal serological survey for evidence of brucella spp and leptospira spp infection of pre-weaned new zealand fur seals in a colony on the otago peninsula.200516317444
brucellosis: the case for live, attenuated vaccines.the successful control of animal brucellosis and associated reduction in human exposure has limited the development of human brucellosis vaccines. however, the potential use of brucella in bioterrorism or biowarfare suggests that direct intervention strategies are warranted. although the dominant approach has explored the use of live attenuated vaccines, side effects associated with their use has prevented widespread use in humans. development of live, attenuated brucella vaccines that are safe ...200919837284
brucella abortus activates human neutrophils.human brucellosis is caused by infection with certain species of the genus brucella and is characterized by bacterial persistence and inflammation of many host tissues. neutrophils are one of the predominant cell types present in the infiltrate of these inflamed tissues, and due to their potential effect on the inflammatory response and tissue damage, direct activation of neutrophils by brucella abortus might contribute to the pathology associated with human brucellosis. b. abortus expresses out ...200919376263
bovine brucellosis.infection of cattle caused by brucella abortus (ie, bovine brucellosis) has been of political importance in the united states for many decades. the most common clinical manifestation of brucellosis in natural hosts is reproductive loss resulting from abortion, birth of weak offspring, or infertility. brucellosis regulatory programs were primarily developed as the most efficient way to prevent human infections. this article discusses cattle vaccination with b abortus strains 19 and rb51. other re ...201020117540
antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.iron maldistribution has been implicated in multiple diseases, including the anemia of inflammation (ai), atherosclerosis, diabetes, and neurodegenerative disorders. iron metabolism is controlled by hepcidin, a 25-amino acid peptide. hepcidin is induced by inflammation, causes iron to be sequestered, and thus, potentially contributes to ai. human hepcidin (hhepc) overexpression in mice caused an iron-deficient phenotype, including stunted growth, hair loss, and iron-deficient erythropoiesis. it ...201020053755
the role of innate immune receptors in the control of brucella abortus infection: toll-like receptors and beyond.research into intracellular sensing of microbial products is an up and coming field in innate immunity. toll-like receptors (tlrs) recognize brucella spp. and bacterial components and initiate mononuclear phagocyte responses that influence both innate and adaptive immunity. recent studies have revealed the intracellular signaling cascades involved in the tlr-initiated immune response to brucella infection. tlr2, tlr4 and tlr9 have been implicated in host interactions with brucella; however, tlr9 ...200818664388
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