Publications

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effective, broad spectrum control of virulent bacterial infections using cationic dna liposome complexes combined with bacterial antigens.protection against virulent pathogens that cause acute, fatal disease is often hampered by development of microbial resistance to traditional chemotherapeutics. further, most successful pathogens possess an array of immune evasion strategies to avoid detection and elimination by the host. development of novel, immunomodulatory prophylaxes that target the host immune system, rather than the invading microbe, could serve as effective alternatives to traditional chemotherapies. here we describe the ...201020523903
brucella abortus infection in man: report of a case. 192920774788
heat-killed and γ-irradiated brucella strain rb51 stimulates enhanced dendritic cell activation, but not function compared with the virulent smooth strain 2308.brucella spp. are gram-negative, facultative intracellular bacterial pathogens that cause abortion in livestock and undulant fever in humans worldwide. brucella abortus strain 2308 is a pathogenic strain that affects cattle and humans. currently, there are no efficacious human vaccines available. however, b. abortus strain rb51, which is approved by the usda, is a live-attenuated rough vaccine against bovine brucellosis. live strain rb51 induces protection via cd4(+) and cd8(+) t-cell-mediated i ...201020812951
comparative analysis of the early transcriptome of brucella abortus - infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis.brucellosis is a worldwide zoonotic infectious disease that has a significant economic impact on animal production and human public health. we characterized the gene expression profile of b. abortus-infected monocyte-derived macrophages (mdms) from naïve cattle naturally resistant (r) or susceptible (s) to brucellosis using a cdna microarray technology. our data indicate that (1) b. abortus induced a slightly increased genome activation in r mdms and a down-regulated transcriptome in s mdms, dur ...201020932540
granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with brucella abortus.osteoarticular complications are common in human brucellosis, but the pathogenic mechanisms involved are largely unknown. since matrix metalloproteinases (mmps) are involved in joint and bone damage in inflammatory and infectious diseases, we investigated the production of mmps by human osteoblasts and monocytes, either upon brucella abortus infection or upon reciprocal stimulation with factors produced by each infected cell type. b. abortus infection of the normal human osteoblastic cell line h ...201020956574
brucella abortus inhibits ifn-γ-induced fcγri expression and fcγri-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages.the strategies that allow brucella abortus to persist for years inside macrophages subverting host immune responses are not completely understood. immunity against this bacterium relies on the capacity of ifn-γ to activate macrophages, endowing them with the ability to destroy intracellular bacteria. we report here that infection with b. abortus down-modulates the expression of the type i receptor for the fc portion of igg (fcγri, cd64) and fcγri-restricted phagocytosis regulated by ifn-γ in hum ...201021070860
thioredoxin 80-activated-monocytes (tams) inhibit the replication of intracellular pathogens.thioredoxin 80 (trx80) is an 80 amino acid natural cleavage product of trx, produced primarily by monocytes. trx80 induces differentiation of human monocytes into a novel cell type, named trx80-activated-monocytes (tams).201121365006
proinflammatory response of human endothelial cells to brucella infection.although vascular pathologies such as vasculitis, endocarditis and mycotic aneurysms have been described in brucellosis patients, the interaction of brucella with the endothelium has not been characterized. in this study we show that brucella abortus and brucella suis can infect and replicate in primary human umbilical vein endothelial cells (huvec) and in the microvascular endothelial cell line hmec-1. infection led to an increased production of il-8, mcp-1 and il-6 in huvec and hmec-1 cells, a ...201121621633
frequency of detection of immunoglobulins of toxoplasma gondii, leptospira spp., and brucella abortus in livestock/farm and abattoir workers in trinidad.toxoplasma gondi, leptospira spp., and brucella abortus are all established parasitic and bacterial zoonoses that manifest themselves in several forms of human diseases. they have been associated with occupational exposures, particularly amongst workers associated with livestock farms. the primary objectives of this study were to determine the seroprevalence of t. gondii immunoglobulin m (igm) immunoglobulins (serum antibodies), leptospira igm immunoglobulins, and b. abortus igg immunoglobulins, ...201121728871
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