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a common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system.the m protein of streptococcus equi subsp. equi known as fibrinogen-binding protein (fgbp) is a cell wall-associated protein with antiphagocytic activity that binds igg. recombinant versions of the seven equine igg subclasses were used to investigate the subclass specificity of fgbp. fgbp bound predominantly to equine igg4 and igg7, with little or no binding to the other subclasses. competitive binding experiments revealed that fgbp could inhibit the binding of staphylococcal protein a and strep ...200818411272
development of an in vivo himar1 transposon mutagenesis system for use in streptococcus equi subsp. equi.streptococcus equi subsp. equi is the causative agent of the equine disease strangles. in this study we describe the development of an in vivo himar1 transposon system for the random mutagenesis of s. equi and, potentially, other gram-positive bacteria. we demonstrate efficient and random transposition of a modified mini-transposon onto the chromosome by southern blot analysis and insertion site sequencing. non-haemolytic mutants were isolated at a frequency of 0.2%, and acapsular mutants at a f ...200415358426
sfs, a novel fibronectin-binding protein from streptococcus equi, inhibits the binding between fibronectin and collagen.the obligate parasitic bacterium streptococcus equi subsp. equi is the causative agent of strangles, a serious disease of the upper respiratory tract in horses. in this study we have, using shotgun phage display, cloned from s. equi subsp. equi and characterized a gene, called sfs, encoding a protein termed sfs, representing a new type of fibronectin (fn)-binding protein. the sfs gene was found to be present in all 50 isolates of s. equi subsp. equi tested and in 41 of 48 s. equi subsp. zooepide ...199910225899
isolation of streptococcus equi subsp. equi from thoroughbred horses in a racehorse-breeding area of japan.for determination whether strangles has invaded the hidaka district of hokkaido, the main racehorse-breeding area of japan, a epizootiological survey with bacterial isolation was carried out during the breeding season in 1995. streptococcus equi subsp. equi, which is the causative agent of strangles, was isolated from two thoroughbred horses with submandibular lymphadenitis. isolates were identified by serological grouping, biochemical tests and analysis of cell surface proteins by western immun ...19979409520
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