Publications

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serosurvey of ex situ giant pandas (ailuropoda melanoleuca) and red pandas (ailurus fulgens) in china with implications for species conservation.conservation strategies for the giant panda (ailuropoda melanoleuca) include the development of a self-sustaining ex situ population. this study examined the potential significance of infectious pathogens in giant pandas ex situ. serologic antibody titers against canine distemper virus (cdv), canine parvovirus (cpv), canine adenovirus (cav), canine coronavirus (ccv), canine herpesvirus, canine parainfluenza virus (cpiv), toxoplasma gondii, neospora caninum, and leptospira interrogans were measur ...200718229861
impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota.the recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. between december 2014 and march 2015, five captive giant pandas died due to canine distemper virus (cdv) infection in china. cdv has taken a heavy toll on tigers and lions in recent years. here, we describe the first gut microbiome diversity study of cdv-infected pandas. by investigating the influence of cdv infection on gut bacte ...201728051146
fatal canine distemper virus infection of giant pandas in china.we report an outbreak of canine distemper virus (cdv) infection among endangered giant pandas (ailuropoda melanoleuca). five of six cdv infected giant pandas died. the surviving giant panda was previously vaccinated against cdv. genomic sequencing of cdv isolated from one of the infected pandas (giant panda/sx/2014) suggests it belongs to the asia-1 cluster. the hemagglutinin protein of the isolated virus and virus sequenced from lung samples originating from deceased giant pandas all possessed ...201627310722
adjuvant effects of recombinant giant panda (ailuropoda melanoleuca) il-18 on the canine distemper disease vaccine in mice.canine distemper virus (cdv) is a morbillivirus known to cause morbidity and mortality in a broad range of animals. giant pandas (ailuropoda melanoleuca), especially captive ones, are susceptible to natural infection with cdv. interleukin-18 (il-18) is a powerful adjuvant molecule that can enhance the development of antigen-specific immunity and vaccine efficacy. in this study, a giant panda il-18 gene eukaryotic expression plasmid (pcamil-18) was constructed. female balb/c mice were muscularly ...201525399820
phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from giant panda and raccoon dogs in china.canine distemper virus (cdv) infects a variety of carnivores, including wild and domestic canidae. in this study, we sequenced and phylogenetic analyses of the hemagglutinin (h) genes from eight canine distemper virus (cdv) isolates obtained from seven raccoon dogs (nyctereutes procyonoides) and a giant panda (ailuropoda melanoleuca) in china.201323566727
serologic survey of giant pandas (ailuropoda melanoleuca), and domestic dogs and cats in the wolong reserve, china.sera from captive and recently rescued giant pandas (ailuropoda melanoleuca) in the wolong reserve, china, were examined by serum neutralization or hemagglutination inhibition for antibodies to canine distemper virus (cdv), canine coronavirus (ccv), canine herpesvirus (chv), pseudorabies virus (prv), canine adenovirus type 2 (cav), and canine parvovirus (cpv). serum samples from village domestic dogs and cats, which run free throughout the reserve also were examined. antibodies against cpv were ...19948151830
serosurvey of selected viruses in captive giant pandas (ailuropoda melanoleuca) in china.serum samples from 92 giant pandas in three captive facilities were tested for antibodies against five viruses of carnivores. antibody titers against canine distemper virus (cdv) in two facilities in which giant pandas were vaccinated were variable. the canine adenovirus (cav-1) and canine parvovirus (cpv) titers in vaccinated group were both positive, but titers were not high and varied among individual except one vaccinated panda had extremely high cav-1 titer, indicating infection with the fi ...201019913371
cross-species recombination in the haemagglutinin gene of canine distemper virus.canine distemper virus (cdv) has high prevalence in the world dog population and poses an important conservation threat to many carnivore species. in this study, extensive phylogenetic and recombination analyses were performed on all available complete haemagglutinin gene sequences and a strain (af178038) isolated from giant panda was identified as putative recombinant. interestingly, the mosaic was produced by recombination between genotypes european wildlife and asia-1 and the recombination ev ...200818550189
serologic response to a canarypox-vectored canine distemper virus vaccine in the giant panda (ailuropoda melanoleuca).the giant panda (ailuropoda melanoleuca) is known to be susceptible to natural infection with canine distemper virus (cdv). vaccination of giant pandas with conventional modified live cdv vaccines has been avoided due to the numerous carnivore species known to have become infected with cdv after vaccination. serum-neutralizing antibodies to cdv were measured after s.c. and i.m. annual vaccination with a canarypox-vectored recombinant cdv vaccine in an adult male and female giant panda over the p ...200717679527
cross-species transmission of canine distemper virus-an update.canine distemper virus (cdv) is a pantropic morbillivirus with a worldwide distribution, which causes fatal disease in dogs. affected animals develop dyspnea, diarrhea, neurological signs and profound immunosuppression. systemic cdv infection, resembling distemper in domestic dogs, can be found also in wild canids (e.g. wolves, foxes), procyonids (e.g. raccoons, kinkajous), ailurids (e.g. red pandas), ursids (e.g. black bears, giant pandas), mustelids (e.g. ferrets, minks), viverrids (e.g. civet ...201528616465
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