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spiral organisms: what are they? a microbiologic introduction to helicobacter pylori.the stomach provides a hostile environment to most microorganisms owing to the antibacterial effect of gastric acidity. however, over the period of mammalian evolution a highly specialized group of bacteria has evolved to inhabit the gastric mucosa. the common features of these bacteria that allow survival in the stomach and colonization of their natural ecologic niche, mucus, are a specialized form of motility, microaerophilism, and very high activity of the enzyme urease. other important adapt ...19911775930
helicobacter felis gastritis in gnotobiotic rats: an animal model of helicobacter pylori gastritis.the gastric spirillum helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with h. felis. at 2 weeks postinoculation, the gastric mucosa of germfree rats had lymphocytes and eosinophils scattered in small foci throughout the subglandular region of the antrum. small numbers of lymphocytes were present in the subglandular portion of the an ...19911997430
characterization of feline helicobacter pylori strains and associated gastritis in a colony of domestic cats.twenty-four young adult domestic cats from a commercial vendor were found to be infected with helicobacter pylori. histopathologic analyses, selected electron microscopy, and urease mapping were performed on mucosal samples collected from the cardias and fundi, bodies, and antra of these cats' stomachs. h. pylori organisms were abundant in all areas of the stomach on the basis of histologic evaluation and urease mapping. h. pylori infection was associated with a moderate to severe lymphofollicul ...19957494015
production of acute gastric erosions in the cat by individual human pepsins.1. differing amounts of human pepsins 1, 3 (pepsin a) and 5 (pepsin c or gastriscin) in aqueous hcl/nacl at ph 1.3 were placed in perspex rings on the exposed luminal surface of the perfused cat stomach to test for mucolytic and erosive activity in vivo, with the acid medium in control rings. 2. after incubation at 37 degrees c for 60 or 120 min, the test and control solutions were replaced by the same volume of each test or control solution containing 18 mg of aspirin and incubated for a furthe ...19957705000
helicobacter pylori-induced gastritis in the domestic cat.helicobacter pylori has been cultured from the inflamed gastric mucosae of naturally infected cats; the lesions in h. pylori-infected cat stomachs mimic many of the features seen in h. pylori-infected human stomachs. to determine whether h. pylori-negative specific-pathogen-free cats with normal gastric mucosae were susceptible to colonization by this bacterium and whether gastritis developed after infections, four h. pylori-negative cats treated with cimetidine were orally dosed three times wit ...19957790084
animal model of human disease: lymphocytic gastritis.gastric specimens from 102 belonging to 11 different species were reviewed. of the 11 species, only the gastric mucosa of pigs contained a large number of lymphocytes in the surface and in the foveolar epithelium (mean 82 lymphocytes/1000 epithelial cells, range 62-128 lymphocytes. the gastric specimens of the remaining 10 species revealed none or occasional lymphocytes in the surface or the foveolar epithelium. the occurrence of intraepithelial lymphocytes in the gastric mucosa of pigs mimics t ...19938110991
acute gastritis associated with spiral organisms from cats.numerous studies implicated helicobacter pylori as one causative agent producing gastritis and dyspepsia. recent reports focus on another bacterium, gastrospirillum hominis, as a possible pathogen producing gastritis. we report a 30-year-old researcher who became acutely ill with epigastric pain indicative of esophagitis or peptic ulcer disease. gastritis and a gastric ulcer were observed endoscopically. histological examination of the gastric mucosa revealed an acute gastritis and large spiral- ...19948149839
helicobacter pylori isolated from the domestic cat: public health implications.helicobacter pylori has been directly linked with active chronic gastritis, peptic ulceration, and gastric adenocarcinoma in humans. although a substantial portion of the human population is colonized with h. pylori, the patterns of transmission of the organism remain in doubt, and reservoir hosts have not been identified. this study documents the isolation of h. pylori from domestic cats obtained from a commercial vendor. the isolation of h. pylori from these cats was confirmed by morphologic a ...19948188360
animal models and vaccine development.following the demonstration of helicobacter pylori as a major gastroduodenal pathogen there was a need to develop animal models in order to investigate mechanisms of pathogenesis and to be able to test new treatment strategies. helicobacter pylori will only colonize a limited number of hosts including non-human primates, germ-free or barrier raised piglets, germ-free dogs and recently laboratory raised cats. although these models have proved useful there is a need for more convenient small anima ...19958563056
how is helicobacter pylori transmitted?helicobacter pylori is one of the world's most common pathogens. it colonizes about 60% of the world's population, causes gastritis and peptic ulcer, and is strongly associated with gastric adenocarcinoma and lymphoma. however, most individuals never develop clinical disease. thirteen years after the culture of h. pylori by marshall and warren, we still do not know its major mode of transmission. childhood represents the major period of acquisition of infection in the third world, but infection ...19979394753
is helicobacter pylori transmitted from cats to humans?subsequent to the isolation of helicobacter pylori from domestic cats, it has been suggested that the organism might be transmitted from cats to humans. this hypothesis has already gained considerable media attention.19969398882
the helicobacter pylori urei protein is not involved in urease activity but is essential for bacterial survival in vivo.we produced defined isogenic helicobacter pylori urei mutants to investigate the function of urei, the product of one of the genes of the urease cluster. the insertion of a cat cassette had a strong polar effect on the expression of the downstream urease genes, resulting in very weak urease activity. urease activity, measured in vitro, was normal in a strain in which urei was almost completely deleted and replaced with a nonpolar cassette. in contrast to previous reports, we thus found that the ...19989712811
transcriptional regulation of the streptococcus salivarius 57.i urease operon.the streptococcus salivarius 57.i ure cluster was organized as an operon, beginning with urei, followed by ureabc (structural genes) and ureefgd (accessory genes). northern analyses revealed transcripts encompassing structural genes and transcripts containing the entire operon. a sigma70-like promoter could be mapped 5' to urei (purei) by primer extension analysis. the intensity of the signal increased when cells were grown at an acidic ph and was further enhanced by excess carbohydrate. to dete ...19989791132
cat owners' risk of acquiring a helicobacter pylori infection.in order to obtain information as to whether or not domestic cats are a significant reservoir for human helicobacter pylori infection, h. pylori antibodies were determined in 59 members of cat protection clubs and in an age- and sex-matched control group. using four different assay systems, the prevalence rates of h. pylori antibodies in the cat owner group compared to the control group were 29% and 34%, respectively (pyloriset dry), 27%/42% (pyloriset eia-g), 14%/29% (pyloriset eia-a), and 37%/ ...19959810653
peptic ulcer disease and exposure to domestic pets.this study assessed whether an association exists between household pets and peptic ulcer disease.19999987471
the design of vaccines against helicobacter pylori and their development.helicobacter pylori is a gram negative, spiral, microaerophylic bacterium that infects the stomach of more than 50% of the human population worldwide. it is mostly acquired during childhood and, if not treated, persists chronically, causing chronic gastritis, peptic ulcer disease, and in some individuals, gastric adenocarcinoma and gastric b cell lymphoma. the current therapy, based on the use of a proton-pump inhibitor and antibiotics, is efficacious but faces problems such as patient complianc ...200111244046
the 26-kilodalton, ahpc homologue, of helicobacter pylori is also produced by other helicobacter species.the 26 kda protein, which is an alkyl hydroperoxide reductase (ahpc) homologue, has earlier been described as specific for helicobacter pylori. the aims of this study were to analyse whether this protein, or the corresponding gene, could be identified in other helicobacter species.200111328365
identification and characterization of gdp-d-mannose 4,6-dehydratase and gdp-l-fucose snthetase in a gdp-l-fucose biosynthetic gene cluster from helicobacter pylori.in this study two open reading frames, namely hp0044 and hp0045 from h. pylori, were cloned and overexpressed in e. coli. the two recombinant proteins were demonstrated to have gdp-d-mannose 4,6-dehydratase (gmd) and gdp-l-fucose synthetase (gfs) activities, respectively. the recombinant gmd was a tetramer and had an optimum ph of 6.5. exogenous nadp(+) was essential for its activity. the k(m) and k(cat) for gdp-d-mannose were 117.3 microm and 0.27 s(-1), respectively. the recombinant gfs was a ...200111444851
sterilizing immunity against experimental helicobacter pylori infection is challenge-strain dependent.the development of a murine model of helicobacter pylori infection through serial in vivo passage of candidate strains has enabled a quantitative assessment of vaccine efficacy. in this study we compare infection with and protection against challenge from both caga(+) type i, and caga(-) type ii in vivo adapted isolates. in vivo passage of a type ii h. pylori isolate resulted in a highly infectious strain (x47-2al), capable of reproducibly infecting mice to high density (10(7) cfu/g of gastric t ...200111535342
helicobacter pylori infection in rural china: exposure to domestic animals during childhood and adulthood.little is known about the mode of transmission of helicobacter pylori, one of the most common human bacterial infections. some domestic animals, including the cat, have been suggested as a reservoir of h. pylori disease, but the data have been inconsistent. this paper evaluates the role of exposure to pets and other domestic animals in the etiology of h. pylori in a rural area of china with a high prevalence of h. pylori infection. in this double-blind, population-based, cross-sectional investig ...200111669227
gastric helicobacters in cats.the types of helicobacter which are found in the stomachs of carnivorous pets, especially cats, have been traditionally referred to as 'gastric helicobacter-like organisms' (ghlos). these are microaerophilic, gram-negative, spiral bacteria with multiple terminal flagellae and are endowed with high-level urease activity which allows them to survive in an acidic environment. certain species have one or more periplasmic fibrils. the two ghlos most commonly found in cats are helicobacter felis and a ...200011716588
cloning and characterization of an outer membrane protein (lip18) from helicobacter bizzozeronii.a recombinant lambda-zap ii phage was selected by screening a genomic library of helicobacter bizzozeronii (hb) using antibodies from a naturally infected cat. dna sequencing resulted an open reading frame containing 172 codons with a predicted molecular mass of 18 kda (lip18). the amino acid sequence showed 22.1, 55.2, 56.7 and 57.1% identity to peptidoglycan-associated lipoprotein of helicobacter pylori, agrobacterium tumefaciens, bartonella bacilliformis, respectively. a peptidoglycan associa ...200312825349
identification of non-helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats.tightly coiled bacteria are a rare cause of gastric pathology in humans and represent a mixture of species for which a zoonotic origin is suspected. similar organisms are common inhabitants of the gastric mucosae of carnivores and pigs. it was the goal of the present study to determine the actual occurrence of each individual helicobacter species in human, canine, and feline stomachs in order to better understand the possible zoonotic significance. gastric biopsy samples from humans with histolo ...200515872252
identification and characterization of neub3 from campylobacter jejuni as a pseudaminic acid synthase.campylobacter jejuni and campylobacter coli are the main causes of bacterial diarrhea worldwide, and helicobacter pylori is known to cause duodenal ulcers. in all of these pathogenic organisms, the flagellin proteins are heavily glycosylated with a 2-keto-3-deoxy acid, pseudaminic acid (5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno-nonulosonic acid). the presence of pseudaminic acid is required for the proper development of the flagella and is thereby necessary for motility in, and invasi ...200516120604
carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from helicobacter pylori.a library of sulfonamides/sulfamates has been investigated for the inhibition of the carboxyterminal truncated form of the alpha-carbonic anhydrase (ca, ec 4.2.1.1) isolated from the gastric pathogen helicobacter pylori (hpca). this enzyme, incorporating 202 amino acid residues, showed a catalytic activity similar to that of the full length hpca, with k(cat) of 2.35 x 10(5)s(-1) and k(cat)/k(m) of 1.56 x 10(7)m(-1)s(-1) at 25 degrees c and ph of 8.9, for the co(2) hydration reaction. all types o ...200616459077
helicobacter and digestive malignancies.important new data were published during the past year on the relationship of helicobacter infection and gastric neoplasias. in the pathogenesis of gastric cancer, a thrilling new hypothesis was put forward based on animal experiments. helicobacter infection induces gastric mucosal damage and bone marrow-derived cells (mobilized into peripheral blood and attracted to the inflamed mucosa) replace the areas of damaged gastric tissue and turn into neoplastic proliferation. several studies focused o ...200616925609
factors associated with h. pylori epidemiology in symptomatic children in buenos aires, argentina.to determine prevalence of h pylori infection in symptomatic children in buenos aires, argentina, and to investigate factors associated with h pylori positivity.200616981273
allergic sensitization and microbial load--a comparison between finland and russian karelia.epidemiological data have indicated that some infections are associated with a low risk of allergic diseases, thus supporting the idea (hygiene hypothesis) that the microbial load is an important environmental factor conferring protection against the development of allergies. we set out to test the hygiene hypothesis in a unique epidemiological setting in two socio-economically and culturally markedly different, although genetically related, populations living in geographically adjacent areas. t ...200717302731
gastric tissue oxidative changes in portal hypertension and cirrhosis.gastric mucosal lesions are very common in portal hypertension and cirrhosis. the aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. the study included 30 patients with cirrhosis and 30 controls. each patient's history, physical examination, and laboratory findings were recorded, and multiple biopsies of the gastric antrum were obtained at endoscopy. a set of antral biopsies was also collected ...200717345161
flavodoxin:quinone reductase (fqrb): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to nadph production in helicobacter pylori and campylobacter jejuni.pyruvate-dependent reduction of nadp has been demonstrated in cell extracts of the human gastric pathogen helicobacter pylori. however, nadp is not a substrate of purified pyruvate:ferredoxin oxidoreductase (pfor), suggesting that other redox active enzymes mediate this reaction. here we show that fqrb (hp1164), which is essential and highly conserved among the epsilonproteobacteria, exhibits nadph oxidoreductase activity. fqrb was purified by nickel interaction chromatography following overexpr ...200717468253
enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from helicobacter pylori.cystathionine gamma-synthase (cgs) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human. in this report, we identified a new metb gene from helicobacter pylori strain ss1, and the recombinant h. pylori cystathionine gamma-synthase (hpcgs) was successfully cloned, expressed and purified in escherichia coli system. enzymatic study of hpcgs indicated that the k(m) and k(cat)/k(m) values against the s ...200817981822
chronic autoimmune thyroiditis (hashimoto's thyroiditis) in patients with malt lymphoma.autoimmune diseases have been implicated in the genesis of malt lymphoma of various localizations. the development of thyroidal malt lymphoma has been described as an adverse event in patients suffering from long-standing chronic autoimmune thyroiditis (cat, hashimoto's thyroiditis). the percentage and possible association between cat and extrathyroidal malt lymphoma, however, have not been assessed so far.200818334510
the nonhuman primate model for h. pylori infection.helicobacter pylori establishes chronic infections in the human gastric mucosa that can last for decades, and that are a major cause of gastritis and peptic ulcer disease (pud) and a risk factor for gastric cancer. the importance of h. pylori as a human pathogen has led to major efforts to understand its interactions with its human host, including the development and use of various animal models. several heterologous models have been developed, including: 1. gnotobiotic newborn piglets, which ar ...199721351038
enterohepatic helicobacter speciesmost of the members of the genus helicobacter do not normally colonize the gastric mucosa, but instead thrive in the mucosal surfaces of the intestinal tract and/or the liver of humans, other mammals, and birds. these enterohepatic helicobacter species have features of ultrastructure and physiology in common with helicobacter pylori and the other gastric helicobacter species, and have been the subject of several recent ...200121290746
draft genome sequence of strain x47-2al, a feline helicobacter pylori isolate.helicobacter pylori is a human-specific pathogen that exclusively inhabits the human gastric mucosa. however, occasionally, humans transmit h. pylori to susceptible animal hosts bred in colonies. here, we report the genome sequence of strain x47-2al, isolated from a domestic cat and used in anti-h. pylori immunization studies.201324356847
the other helicobacters.the last year has seen an interesting and important collection of evidence presented in the field of the "other" than helicobacter pylori helicobacters. associations with adult ulcerative colitis and biliary/hepatic disease have been described. new insights into the immune response and subsequent pathogenesis associated with infection have also been published. genomic advances include description of new and unique species and the complete genome description for both helicobacter felis and helico ...201121896089
helicobacter spp. other than helicobacter pylori.over the last 12 months, new insights into the association of non-helicobacter pylori helicobacters with a range of human diseases in children and adults, including hepatobiliary disease, crohn's disease, sepsis, and gastric disease were published. studies investigating the presence of non-h. pylori helicobacters in domestic animals reinforce previous findings that cats and dogs harbor gastric helicobacter species and thus may be an important source of these organisms in humans. the confounding ...201021054656
kinetic and structural properties of triosephosphate isomerase from helicobacter pylori.triosephosphate isomerase (tim) catalyzes the interconversion between dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate in the glycolysis-gluconeogenesis metabolism pathway. the helicobacter pylori tim gene (hptim) was cloned, and hptim was expressed and purified. the enzymatic activity of hptim for the substrate gap was determined (k(m) = 3.46 +/- 0.23 mm and k(cat) = 8.8 x 10(4) min(-1)). the crystal structure of hptim was determined by molecular replacement at 2.3 a resolution. the ...200817957775
helicobacter felis and helicobacter bizzozeronii induce gastric parietal cell loss in mongolian gerbils.non-pylori helicobacter infections are associated with gastritis, gastric ulcers and malt lymphomas in man. approximately 50% of these are caused by helicobacters commonly found in dogs and cats, including helicobacter felis, helicobacter bizzozeronii and h. salomonis. in contrast to helicobacter pylori, the virulence mechanisms of these species are unknown. in this study the virulence of h. felis, h. bizzozeronii and h. salomonis was investigated in mongolian gerbils. female spf gerbils were in ...200616311055
an overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research.four types of experimental chronic ulcer models, named acetic acid ulcer models, have been developed to examine the healing process of peptic ulcers, screen anti-ulcer drugs, and better evaluate the adverse effects of various anti-inflammatory drugs on the gastrointestinal mucosa. the model easily and reliably produces round, deep ulcers in the stomach and duodenum, allowing acetic acid ulcer production in mice, rats, mongolian gerbils, guinea pigs, cats, dogs, miniature pigs, and monkeys. these ...200516079471
molecular cloning and functional expression of a novel helicobacter pylori alpha-1,4 fucosyltransferase.helicobacter pylori is an important human pathogen which causes both gastric and duodenal ulcers and is associated with gastric cancer and lymphoma. this microorganism synthesizes fucosylated oligosaccharides, predominantly the galb-1,4glcnac (type ii) blood group antigens lewis x and y, whereas a small population also expresses the galb-1,3glcnac (type i) blood group antigens lewis a and b. these carbohydrate structures are known to mimic host cell antigens and permit the bacteria to escape fro ...200516000696
restriction of dna encoding selectable markers decreases the transformation efficiency of helicobacter pylori.helicobacter pylori populations recovered from the human stomach display extensive recombination and quasispecies development, and this suggests frequent exchange of dna between different strains in vivo. in vitro, however, most h. pylori strains display restriction to the uptake of non-self dna, as measured using selectable markers, regardless of their competency for transformation with self dna. we have examined the effect of different selectable markers on double-crossover recombination effic ...200515866218
animal models of helicobacter pylori infection and disease.the acceptance of helicobacter pylori as a major human pathogen has necessitated the development of animal models to help elucidate the pathogenic mechanisms of this bacterium and aid in the development of improved strategies for the treatment of gastric disease. appropriate models, utilising a range of animal species, have been developed to examine factors such as the influence of host responses and bacterial factors in disease development and the success of new therapeutic regimens, including ...200312814775
helicobacter pylori: epidemiology and routes of transmission.h. pylori is a common bacterium, and approximately 50 percent of the world's population has been estimated to be infected (198). humans are the principal reservoir. the prevalence of h. pylori infection varies widely by geographic area, age, race, ethnicity, and ses. rates appear to be higher in developing than in developed countries, with most of the infections occurring during childhood, and they seem to be decreasing with improvements in hygiene practices. h. pylori causes chronic gastritis a ...200011218379
helicobacter infection in dogs and cats: facts and fiction.the discovery of the spiral bacterium helicobacter pylori and its causative role in gastric disease in humans has brought a dramatic change to gastroenterology. although spiral bacteria have been known for more than a century to infect the stomachs of dogs and cats, recent research has been conducted mainly in the wake of interest in h. pylori. h. pylori has not been found in dogs and only very rarely in cats and zoonotic risk is minimal. a variety of other helicobacter spp. can infect the stoma ...200010772482
helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease.a natural infection with helicobacter pylori (h. pylori) in domestic cats (felis cattus) less than 2 years of age has been well described in a closed colony of animals. six cats from this colony that were serially evaluated by culture, polymerase chain reaction, and light and electron microscopy for a period of 3 years demonstrated persistent gastric colonization with a single cag(-) vac(+) strain of h. pylori. in these cats, as well as five other 5- to 6-year-old cats that were examined, a long ...200010666399
[helicobacter heilmannii in the pathology of the stomach and duodenum].historical aspects of the discovery of the spiral-like non-spirochetal bacteria belonging to helicobacter and called helicobacter heilmannii (hh)--previous name gastrospirillum hominis--and producing under some conditions, like helicobacter pylori, analogous gastroduodenal pathology (chronic gastritis, gastric ulcer, malt-lymphoma and stomach cancer) are presented. microbiological and structural features of this agent are considered as well as its relations with an apical surface of epitheliocyt ...199910476352
routes of transmission of helicobacter pylori infection.helicobacter pylori is an important gastroduodenal pathogen, which has been recognized as a class i carcinogen factor for gastric cancer and gastric mucosa associated lymphoid tissue lymphomas. in spite of the world-wide spread of the infection, the route of transmission is still not known. we reviewed data from several sero-epidemiological studies and aimed to identify potential sources of helicobacter pylori infection. available evidence strongly suggests an inverse correlation between socio-e ...199810077755
[anti-helicobacter vaccination: very far away or very close?]. 19989549203
[the modes of transmission of helicobacter pylori infection].helicobacter pylori plays an essential role in the development of several both acid-related and neoplastic gastroduodenal pathologies. there are still uncertainties about the transmission routes and the sources of h. pylori infection. man is the only well established "reservoir" of h. pylori, while the role of other mammalians (cat, pig, primates), as sources of infection, is still controversy. literature data suggest four different modalities of transmission of the infection: faeco-oral, oro-or ...19979244959
scientific information document helicobacter pylori. 19968981285
helicobacter pylori and stomach ulcers. 19968873407
use of pcr and culture to detect helicobacter pylori in naturally infected cats following triple antimicrobial therapy.helicobacter pylori causes gastritis and peptic ulcers and is linked to gastric cancer. domestic cats from a commercial source were found to be naturally infected with h. pylori, and studies were undertaken to eradicate h. pylori from infected cats by using triple antimicrobial therapy. eight cats infected with h. pylori were used in the study. six cats received a 21-day course of oral amoxicillin, metronidazole, and omeprazole, and two cats served as controls. two weeks and 4 weeks posttreatmen ...19968726024
aflagellated mutants of helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesis.three out of 10 helicobacter pylori clinical isolates were found to be naturally competent for genetic transformation to streptomycin resistance by chromosomal dna extracted from a spontaneous streptomycin-resistant h. pylori mutant. the frequency of transformation varied between 5 x 10(-4) and 4 x 10(-6), depending on the h. pylori isolate used. transposon shuttle mutagenesis based on this natural competence was established using the flagellin gene flaa as the target. the cloned flaa gene was i ...19938332066
use of a mouse model to examine anti-helicobacter pylori agents.a mouse model of helicobacter infection of the gastric mucosa was evaluated for in vivo screening of new anti-helicobacter pylori therapies. the aim of the study was to test antimicrobial agents with known anti-h. pylori effects in humans to validate that similar results were obtained in the mouse model. specific pathogen-free mice were colonized with h. felis, a cat stomach isolate that has been shown to induce chronic gastritis in gnotobiotic mice. in h. felis-inoculated mice 4 weeks after tre ...19911947781
evaluation of gastric lesions based on helicobacter pylori and helicobacter-like organisms (hlos) in cats; a histopathological and bacteriological study.the lesions induced by helicobacter pylori in a candidate animal model should always be examined thoroughly. the resemblance of these lesions to those observed in humans can indicate whether the usage of this model will contribute to the understanding of the various pathogenic mechanisms involved in the development of human h. pylori-associated diseases.201425371810
a mixed population of helicobacter pylori, helicobacter bizzozeronii and "helicobacter heilmannii" in the gastric mucosa of a domestic cat.the presence of helicobacter within the gastric mucosa is responsible for producing pathology in many animal species, including man. since humans have been shown to harbour many of the same bacterial species as domestic carnivores, concern over their zoonotic potential has been growing. helicobacter pylori, a class 1 carcinogen responsible for cases of gastritis and gastric cancer in humans, produces similar pathology in pet carnivores and is considered an example of anthroponosis. the case here ...201425905013
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