| vaccinia recombinant virus expressing the rabies virus glycoprotein: safety and efficacy trials in canadian wildlife. | twenty-six meadow voles (microtus pennsylvanicus), ten woodchucks (marmota monax), thirteen grey squirrels (sciurus carolinensis), thirteen ring-billed gulls (larus delawarensis), six red-tailed hawks (buteo jamaicensis) and eight great horned owls (bubo virginianus) received vaccinia virus recombinant expressing the rabies virus glycoprotein (v-rg) by direct instillation into the oral cavity. each of ten coyotes (canis latrans) received the virus in two vaccine-laden baits. several voles and mo ... | 1990 | 2249183 |
| observations on the pathogenesis of rabies: experimental infection with a virus of coyote origin. | | 1974 | 4844503 |
| rabies surveillance in the united states during 1994. | in 1994, 48 states, the district of columbia, and puerto rico reported 8,224 cases of rabies in nonhuman animals and 6 cases in human beings to the centers for disease control and prevention. nearly 93% (7,632 cases) were wild animals, whereas 7% (592 cases) were domestic species. the total number of reported cases decreased 13.4% from that of 1993 (9,498 cases), with most of the decline resulting from 19.2% fewer cases of rabies in raccoons. two previously described epizootics of rabies involvi ... | 1995 | 7493894 |
| translocation of coyote rabies--florida, 1994. | translocation of a rabies variant from one area to another has been identified increasingly in the united states. during november and december 1994, rabies was diagnosed in five dogs from two associated kennels in florida; in addition, two other dogs being kept at one of the kennels died with suspected, but unconfirmed, rabies. rabies virus recovered from the five dogs was identified as a variant not previously found in florida but endemic in coyotes (canis latrans) in south texas. the suspected ... | 1995 | 7623760 |
| rabies surveillance in the united states during 1993. | in 1993, 49 states, the district of columbia, and puerto rico reported 9,495 cases of rabies in nonhuman animals and 3 cases in human beings to the centers for disease control and prevention. greater than 93% (8,889 cases) were wild animals, whereas 6.4% (606 cases) were domestic species. the total number of reported cases increased 9.9% over that of 1992 (8,645 cases), with most of the increase resulting from continued spread of rabies in raccoons (37.1% increase in reported cases over 1992). t ... | 1994 | 7744643 |
| characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in north america. | the silver-haired bat variant of rabies virus (shbrv) has been identified as the etiological agent of a number of recent human rabies cases in the united states that are unusual in not having been associated with any known history of conventional exposure. comparison of the different biological and biochemical properties of isolates of this virus with those of a coyote street rabies virus (cosrv) revealed that there are unique features associated with shbrv. in vitro studies showed that, while t ... | 1996 | 8643632 |
| rabies surveillance in the united states during 1995. | in 1995, 49 states, the district of columbia, and puerto rico reported 7,877 cases of rabies in nonhuman animals and 4 cases in human beings to the centers for disease control and prevention. nearly 92% (7,247 cases) were wild animals, whereas 8% (630 cases) were domestic species. the total number of reported cases decreased 4.2% from that of 1994 (8,230 cases). most of the decline was the result of 17.1% fewer reported cases of rabies in raccoons in areas of the northeast, where rabies is now e ... | 1996 | 8960176 |
| field use of a vaccinia-rabies recombinant vaccine for the control of sylvatic rabies in europe and north america. | during recent years, most research on the control of sylvatic rabies has concentrated on developing methods of oral vaccination of wild rabies vectors. to improve both the safety and the stability of the vaccine used, a recombinant vaccinia virus, which expresses the immunising glycoprotein of rabies virus (vrg), has been developed and tested extensively in the laboratory as well as in the field. from 1989 to 1995, approximately 8.5 million vrg vaccine doses were dispersed in western europe to v ... | 1996 | 9025144 |
| molecular epidemiology of rabies epizootics in texas. | texas is in the midst of two independent epizootics of rabies, involving coyotes (canis latrans) and domestic dogs (canis familiaris) in southern texas and grey foxes (urocyon cinereoargenteus) in west central texas. the domestic dog/coyote (ddc) and grey for (tf) rabies virus variants cannot be differentiated by antigenic typing with currently available monoclonal antibodies. these two variants also cannot be distinguished from a third variant, sonora dog (sd) rabies, that is not enzootic in te ... | 1997 | 9406651 |
| rabies surveillance in the united states during 1996. | in 1996, 49 states, the district of columbia, and puerto rico reported 7,124 cases of rabies in non-human animals and 4 cases in human beings to the centers for disease control and prevention. nearly 92% (6,550 cases) were wild animals, whereas 8% (574 cases) were domestic species. the total number of reported cases decreased 9.6% from that of 1995 (7,881 cases). although much of the decline was the result of fewer reported cases of rabies in raccoons, fewer cases were also reported among most g ... | 1997 | 9412679 |
| rabies surveillance in the united states during 1997. | in 1997, 49 states, the district of columbia, and puerto rico reported 8,509 cases of rabies in nonhuman animals and 4 cases in human beings to the centers for disease control and prevention. nearly 93% (7,899) were wild animals, whereas 7% (610) were domestic species. the total number of reported cases increased 19.4% from that of 1996 (7,128 cases). increases were apparent in each of the major species groups, with the exception of cattle. the relative contributions of these groups to the total ... | 1998 | 9861958 |
| use of anti-glycoprotein monoclonal antibodies to characterize rabies virus in formalin-fixed tissues. | seventy anti-rabies virus monoclonal antibodies (mabs) were tested for reactivity with rabies and rabies-related viruses in formalin-fixed (ff) tissues. forty-three of the mabs were directed against the glycoprotein and 27 were directed against the nucleocapsid as determined by enzyme immunoassays and neutralization tests. twenty of the anti-glycoprotein mabs and one of the anti-nucleocapsid mabs reacted with the rabies challenge virus strain (cvs) in ff tissue. these 21 mabs were screened again ... | 1999 | 10029326 |
| typing of rabies virus isolates by dna enzyme immunoassay. | alternatives to antigenic typing are needed for epidemiologic surveys of the rabies virus associated with translocated coyotes and foxes, especially in areas where a closely related rabies virus is transmitted by striped skunks. | 1999 | 10073409 |
| serological responses of coyotes to two commercial rabies vaccines. | between august 1993 and september 1994 we documented serological responses of coyotes (canis latrans) vaccinated with two commercial rabies vaccines licensed for use in domestic dogs. serologic responses were documented by testing for rabies virus neutralizing antibodies with the rapid fluorescent focus inhibition test (rffit) at 30, 90, 180, 270, and 365 days post-vaccination. all coyotes vaccinated with imrab 3 (rhone-merieux, inc.), and 75% of those vaccinated with dura-rab 3 (immunovet, inc. ... | 2001 | 11763743 |
| rabies surveillance in the united states during 2000. | during 2000, 49 states, the district of columbia, and puerto rico reported 7,364 cases of rabies in nonhuman animals and 5 cases in human beings to the centers for disease control and prevention, an increase of 4.3% from 7,067 cases in nonhuman animals reported in 1999. ninety-three percent (6,855 cases) were in wild animals, whereas 6.9% (509 cases) were in domestic species (compared wth 91.5% in wild animals and 8.5% in domestic species in 1999). compared with cases reported in 1999, the numbe ... | 2001 | 11767918 |
| oral efficacy of an attenuated rabies virus vaccine in skunks and raccoons. | raccoons and skunks are major rabies reservoirs in north america. oral vaccination is one method to consider for disease control in these carnivores. under field conditions in the usa, only one oral rabies vaccine has been used. it is efficacious in wildlife such as raccoons (procyon lotor), coyotes (canis latrans), and foxes (vulpes vulpes) but not in skunks (mephitis mephitis). the objectives of this study were to evaluate an attenuated sag-2 rabies virus vaccine for safety, immunogenicity, an ... | 2002 | 12038142 |
| rabies surveillance in the united states during 2001. | during 2001, 49 states and puerto rico reported 7,437 cases of rabies in nonhuman animals and 1 case in a human being to the centers for disease control and prevention, an increase of < 1% from 7,364 cases in nonhuman animals and 5 human cases reported in 2000. more than 93% (6,939 cases) were in wild animals, whereas 6.7% (497 cases) were in domestic species (compared with 93.0% in wild animals and 6.9% in domestic species in 2000). the number of cases reported in 2001 increased among bats, cat ... | 2002 | 12494966 |
| rabies surveillance in the united states during 2002. | during 2002, 49 states and puerto rico reported 7,967 cases of rabies in nonhuman animals and 3 cases in human beings to the centers for disease control and prevention, an increase of 7.2% from the 7,436 cases in non-human animals and 1 case in a human being reported in 2001. more than 92% (7,375 cases) were in wild animals, whereas 7.4% (592) were in domestic species (compared with 93.3% in wild animals and 6.7% in domestic species in 2001). compared with cases reported in 2001, the numbers of ... | 2003 | 14690203 |
| rabies surveillance in the united states during 2003. | during 2003, 49 states and puerto rico reported 7,170 cases of rabies in nonhuman animals and 3 cases in human beings to the cdc. this represents a 10% decrease from the 7,967 cases in nonhuman animals and 3 cases in human beings reported in 2002. more than 91 (n = 6,556) were in wild animals, and 8.6% (614) were in domestic species (compared with 92.5% in wild animals and 74% in domestic species in 2002). the relative contributions of the major groups of animals were as follows: 2,635 raccoons ... | 2004 | 15643834 |
| status of oral rabies vaccination in wild carnivores in the united states. | persistence of multiple variants of rabies virus in wild chiroptera and carnivora presents a continuing challenge to medical, veterinary and wildlife management professionals. oral rabies vaccination (orv) targeting specific carnivora species has emerged as an integral adjunct to conventional rabies control strategies to protect humans and domestic animals. orv has been applied with progress toward eliminating rabies in red foxes (vulpes vulpes) in western europe and southern ontario, canada. mo ... | 2005 | 15896404 |
| evaluation of oral rabies vaccination programs for control of rabies epizootics in coyotes and gray foxes: 1995-2003. | to evaluate the effectiveness of intervention efforts to halt 2 wildlife rabies epizootics from 1995 through 2003, including 9 oral rabies vaccination campaigns for coyotes and 8 oral rabies vaccination campaigns for gray foxes. | 2005 | 16178403 |
| [epidemiology of rabies virus and other lyssaviruses]. | rabies is a zoonosis that infects domestic and wild animals through close contacts with saliva from infected animals. the annual number of deaths worldwide caused by rabies is estimated approximately 55,000 by world health organization (who). there has been no indigenous rabies case in japan since 1957; however, there was only one imported case, a traveler who was bitten by a stray dog in nepal and died in 1970. dogs in asia and africa remain the main reservoir and transmitter of rabies to human ... | 2005 | 16363690 |
| rabies surveillance in the united states during 2004. | during 2004, 49 states and puerto rico reported 6,836 cases of rabies in nonhuman animals and 8 cases in human beings to the cdc, representing a 4.6% decrease from the 7,170 cases in nonhuman animals and 3 cases in human beings reported in 2003. approximately 92% of the cases were in wildlife, and 8% were in domestic animals (compared with 91% and 9%, respectively, in 2003). relative contributions by the major animal groups were as follows: 2,564 raccoons (37.5%), 1,856 skunks (27.1%), 1,361 bat ... | 2005 | 16379626 |
| rabies surveillance in the united states during 2005. | during 2005, 49 states and puerto rico reported 6,417 cases of rabies in nonhuman animals and 1 case in a human being to the cdc, representing a 6.2% decrease from the 6,836 cases in nonhuman animals and 8 cases in human beings reported in 2004. approximately 92% of the cases were in wildlife, and 8% were in domestic animals. relative contributions by the major animal groups were as follows: 2,534 raccoons (39.5%), 1,478 skunks (23%), 1,408 bats (21.9%), 376 foxes (5.9%), 269 cats (4.2%), 93 cat ... | 2006 | 17173527 |
| rabies surveillance in the united states during 2006. | during 2006, 49 states and puerto rico reported 6,940 cases of rabies in animals and 3 cases in humans to the cdc, representing an 8.2% increase from the 6,417 cases in animals and 1 case in a human reported in 2005. approximately 92% of the cases were in wildlife, and 8% were in domestic animals. relative contributions by the major animal groups were as follows: 2,615 raccoons (37.7%), 1,692 bats (24.4%), 1,494 skunks (21.5%), 427 foxes (6.2%), 318 cats (4.6%), 82 cattle (1.2%), and 79 dogs (1. ... | 2007 | 17696853 |
| rabies surveillance in the united states during 2007. | summary: during 2007, 49 states and puerto rico reported 7,258 cases of rabies in animals and 1 case in a human to the cdc, representing a 4.6% increase from the 6,940 cases in animals and 3 cases in humans reported in 2006. approximately 93% of the cases were in wildlife, and 7% were in domestic animals. relative contributions by the major animal groups were as follows: 2,659 raccoons (36.6%), 1,973 bats (27.2%), 1,478 skunks (20.4%), 489 foxes (6.7%), 274 cats (3.8%), 93 dogs (1.3%), and 57 ca ... | 2008 | 18795848 |
| economic evaluation of an oral rabies vaccination program for control of a domestic dog-coyote rabies epizootic: 1995-2006. | to conduct a benefit-cost analysis of the results of the domestic dog and coyote (ddc) oral rabies vaccine (orv) program in texas from 1995 through 2006 by use of fiscal records and relevant public health data. | 2008 | 19046031 |
| oral rabies vaccination in north america: opportunities, complexities, and challenges. | steps to facilitate inter-jurisdictional collaboration nationally and continentally have been critical for implementing and conducting coordinated wildlife rabies management programs that rely heavily on oral rabies vaccination (orv). formation of a national rabies management team has been pivotal for coordinated orv programs in the united states of america. the signing of the north american rabies management plan extended a collaborative framework for coordination of surveillance, control, and ... | 2009 | 20027214 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| global mammal parasite database version 2.0. | illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy, and human health. extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods, and fungi). here we present an updated version of the global mammal parasite database, a database of the parasites of wild ungulates (artioda ... | 2017 | 28273333 |
| serologic survey for cross-species pathogens in urban coyotes (canis latrans), colorado, usa. | abstract as coyotes (canis latrans) adapt to living in urban environments, the opportunity for cross-species transmission of pathogens may increase. we investigated the prevalence of antibodies to pathogens that are either zoonotic or affect multiple animal species in urban coyotes in the denver metropolitan area, colorado, usa, in 2012. we assayed for antibodies to canine parvovirus-2, canine distemper virus, rabies virus, toxoplasma gondii, yersinia pestis, and serotypes of leptospira interrog ... | 2014 | 25121408 |
| animal rabies in massachusetts, 1985-2006. | in this study, we review annual rabies data from massachusetts from 1985 to 2006, spanning the introduction of raccoon strain rabies in 1992. of 52,034 animals tested, 9.7% (5,049/52,034) were rabid, representing 26 of over 67 species submitted. bats were the most common rabid animals prior to 1992 (50 of 52), but raccoons (procyon lotor) became the most common rabies-positive species upon arrival of raccoon strain rabies virus (38.2%, 2,728 of 7,138 tested), followed by striped skunks (mephitis ... | 2009 | 19395747 |
| efficacy of rabies biologics against new lyssaviruses from eurasia. | new causative agents of rabies continue to emerge as shown by the recent description of four novel lyssaviruses from bats in eurasia, aravan (arav), khujand (khuv), irkut (irkv), and west caucasian bat virus (wcbv). the effect of rabies vaccination prior to exposure to these new lyssaviruses was investigated in two animal models (i.e., syrian hamsters and ferrets). the hamsters were vaccinated intramuscularly with a commercial human or veterinary vaccine or with an experimental vaccinia-rabies g ... | 2005 | 15896401 |
| oral vaccination of wildlife against rabies: opportunities and challenges in prevention and control. | rabies is an acute, progressive, fatal encephalitis caused by viruses in the family rhabdoviridae, genus lyssavirus. rabies virus is the representative member of the group. warm-blooded vertebrates are susceptible to experimental infection, but major primary hosts for disease perpetuation encompass bats and mammalian carnivores. the dog is the global reservoir, and important wild carnivores include foxes, raccoons, skunks, and mongoose, among others. traditionally, reliance upon long-term, wides ... | 2004 | 15742629 |
| rabies among infrequently reported mammalian carnivores in the united states, 1960-2000. | most cases of rabies reported annually in the united states occur among three groups of carnivores--raccoons (procyon lotor), skunks (mephitis, spilogale, and putorius), foxes (vulpes, urocyon, and alopex)--and among bats (numerous species). however, between 1960 and 2000, a total of 2,851 cases of rabies in 17 other carnivore taxa were reported to the centers for disease control and prevention, atlanta, georgia (usa), from 49 states, the district of columbia, and puerto rico. three species of t ... | 2003 | 12910751 |
| new approaches to the development of live attenuated rabies vaccines. | in the united states, extensive reservoirs of the rabies virus exist in many diverse wild animal species, which continue to pose a serious risk of lethal infection of humans and cause an economic burden exceeding $1 billion annually. previous experience with rabies control in foxes in europe has clearly demonstrated that oral immunization with live vaccines is the only practical approach to eradicate rabies in free-ranging animals. however, unlike europe where vulpine rabies was the only major r ... | 2002 | 12031103 |
| mucosal adjuvants to improve wildlife rabies vaccination. | raboral v-rg(®)a is a recombinant vaccine used in oral rabies vaccination (orv) programs for wildlife in the united states. vaccination rates for raccoons are substantially lower than vaccination rates for gray foxes and coyotes. research suggests that the low viscosity of the oral vaccine may preclude animals from receiving an effective dose when biting into the vaccine bait delivery system. we evaluated the possibility of using two benign compounds, chitosan and n,n,n-trimethylated chitosan (t ... | 2012 | 23060506 |
| management and modeling approaches for controlling raccoon rabies: the road to elimination. | rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. in the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. however, in north america, where several rabies virus variants currently circulate in wildlife, human contact with the raccoon rabies variant leads to the highest per capita population administration of post-exposure prophylaxis (pep) annually. previous ra ... | 2017 | 28301480 |
| the history of rabies in the western hemisphere. | before the introduction of control programs in the 20th century, rabies in domestic dogs occurred throughout the western hemisphere. however, historical records and phylogenetic analysis of multiple virus isolates indicate that, before the arrival of the first european colonizers, rabies virus was likely present only in bats and skunks. canine rabies was either rare or absent among domestic dogs of native americans, and first arrived when many new dog breeds were imported during the period of eu ... | 2017 | 28365457 |