TitleAbstractYear(sorted ascending)
helicobacter acinonyx sp. nov., isolated from cheetahs with gastritis.four strains of a novel helicobacter species were isolated from the stomachs of cheetahs (acinonyx jubilatus) with gastritis. these isolates were phenotypically similar to helicobacter pylori. the isolates were gram-negative, spiral bacteria which grew under microaerophilic conditions at 37 degrees c, but not at 25 or 42 degrees c, and produced urease, catalase, oxidase, alkaline phosphatase, and gamma-glutamyl transpeptidase. the isolates did not ferment glucose, mannitol, inositol, sorbitol, r ...19938379970
genetic evidence for host specificity in the adhesin-encoding genes hxaa of helicobacter acinonyx, hnaa of h. nemestrinae and hpaa of h. pylori.gastric and non-gastric species of helicobacter were examined for the presence of the adhesin-encoding gene, hpaa, from the human-associated gastric helicobacter h. pylori (hp), and for adhesin subunit protein hpaa. amplification of a 375-bp internal dna fragment of hpaa by pcr demonstrated the presence of the gene in hp and in two closely related gastric helicobacters, h. nemestrinae (hn) and h. acinonyx (hx), but not in the more distantly related h. felis (hf) and h. mustelae (hm). the non-gas ...19957557486
treatment of gastritis in cheetahs (acinonyx jubatus).three cheetahs (acinonyx jubatus) had a clinical history of chronic spiral bacteria-associated gastritis and three cheetahs had no clinical history of gastritis. gastric biopsies were obtained from all six cheetahs prior to treatment for gastritis and 3 wk and 1 yr posttreatment. the cheetahs were treated with tetracycline hydrochloride 500 mg p.o. q.i.d., metronidazole 250 mg p.o. q.i.d., and bismuth subsalicylate 300 mg p.o. q.i.d. each drug was administered concurrently for 7 days. following ...19979365937
chronic gastritis in tigers associated with helicobacter acinonyx.helicobacter pylori-like organisms (hplos) were isolated from the gastric mucosa of two sumatran tigers and identified by polymerase chain reaction analysis as helicobacter acinonyx. at histological examination, both tigers revealed a chronic gastritis associated with hplos as demonstrated by immunolabelling and electron microscopy. this is the first isolation of h. acinonyx from tigers, in which, as previously reported in cheetahs, it may be a cause of gastritis.19989717128
systemic candidiasis in a cheetah (acinonyx jubatus).systemic candidiasis, with involvement of the spleen, liver, kidneys, and lymph nodes, was diagnosed in a geriatric captive cheetah (acinonyx jubatus). the animal had a long clinical history of intermittent chronic gastritis associated with helicobacter acinonyx and chronic renal failure, both of which were repeatedly treated with broad-spectrum antimicrobial therapy. following euthanasia, a postmortem examination showed numerous microabscesses and granulomas composed of degenerate eosinophils a ...199810065861
helicobacter acinonychis: genetic and rodent infection studies of a helicobacter pylori-like gastric pathogen of cheetahs and other big cats.insights into bacterium-host interactions and genome evolution can emerge from comparisons among related species. here we studied helicobacter acinonychis (formerly h. acinonyx), a species closely related to the human gastric pathogen helicobacter pylori. two groups of strains were identified by randomly amplified polymorphic dna fingerprinting and gene sequencing: one group from six cheetahs in a u.s. zoo and two lions in a european circus, and the other group from a tiger and a lion-tiger hybr ...200414702304
who ate whom? adaptive helicobacter genomic changes that accompanied a host jump from early humans to large felines.helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. a closely related species, helicobacter acinonychis, is specific for large felines, including cheetahs, lions, and tigers, whereas hosts more closely related to humans harbor more distantly related helicobacter species. this observation suggests a jump between host species. but who ate whom and when did it happen? in order to resolve this question, we determined the ...200616789826
characterization of α2,3- and α2,6-sialyltransferases from helicobacter acinonychis.genome sequence data were used to clone and express two sialyltransferase enzymes of the gt-42 family from helicobacter acinonychis atcc 51104, a gastric disease isolate from cheetahs. the deposited genome sequence for these genes contains a large number of tandem repeat sequences in each of them: hac1267 (rqkele)(15) and hac1268 (eekllefkni)(13). we obtained two clones with different numbers of repeat sequences for the hac1267 gene homolog and a single clone for the hac1268 gene homolog. both g ...201222504533
electron microscopic, genetic and protein expression analyses of helicobacter acinonychis strains from a bengal tiger.colonization by helicobacter species is commonly noted in many mammals. these infections often remain unrecognized, but can cause severe health complications or more subtle host immune perturbations. the aim of this study was to isolate and characterize putative novel helicobacter spp. from bengal tigers in thailand. morphological investigation (gram-staining and electron microscopy) and genetic studies (16srrna, 23srrna, flagellin, urease and prophage gene analyses, rapd dna fingerprinting and ...201323940723
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