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production and characterization of monoclonal antibodies to cervine herpesvirus-1.fourteen hybridoma cell lines secreting monoclonal antibodies (mab) to cervine herpesvirus-1 (cerhv-1) produced following the fusion of nso myeloma cells with splenocytes of balb/c mice previously immunized with gradient purified cerhv-1 were selected using an indirect enzyme-linked immunosorbent assay (elisa) employing cerhv-1 antigen and tested by the elisa against four other ruminant alphaherpesviruses from cattle (bovine herpesvirus type 1.1 and 1.2) goat (caprine herpesvirus-2) and reindeer ...19921333671
monoclonal antibodies that distinguish between encephalitogenic bovine herpesvirus type 1.3 and respiratory bovine herpesvirus type 1.1.seven mouse hybridoma cell lines producing monoclonal antibodies (mab) against an encephalitogenic strain of bovine herpesvirus type 1.3 (bhv-1.3) were established. the clones producing mab were selected to be specific for bhv-1.3 by enzyme-linked immunosorbent assay. only l1b neutralized virus without complement. with the addition of complement, five of the mab neutralized bhv-1.3 but not the respiratory strain bhv-1.1. the anti-bhv-1.3-specific mab q10b, l6g, and l1b precipitated glycoproteins ...19947496928
antigenic differences between the major glycoproteins of bovine herpesvirus type 1.1 and bovine encephalitis herpesvirus type 1.3.differences in the antigenic structure of the major glycoproteins, gi, giii and giv, of bovine herpesvirus type 1.1 (bhv1.1) and the neurovirulent bhv1.3 were demonstrated with a panel of monoclonal antibodies (mabs) prepared against the bhv1.1 glycoproteins. glycoprotein giii of bhv1.3 was the most dissimilar, reacting with only four of 15 giii-specific mabs. glycoproteins gi and giv of bhv1.3 reacted with eight of 11 and eight of 12 specific mabs, respectively. monospecific bovine antisera to ...19937688409
cellular expression of bovine herpesvirus 1 gd inhibits cell-to-cell spread of two closely related viruses without blocking their primary infection.alphaherpesviral glycoprotein d (gd) is a critical component of the cell membrane penetration system. cells that express gd of herpes simplex virus type 1 (hsv1), pseudorabies virus (prv), or bovine herpesvirus type 1.1 (bhv1.1) resist infection by the homologous virus due to interference with viral entry at the level of penetration. bhv1.1 gd interferes with the distantly related viruses hsv1 and prv despite only a 30-40% sequence similarity and the complete absence of antigenic cross-reactivit ...19999927571
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