| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| molecular cloning and functional characterization of porcine cyclic gmp-amp synthase. | cyclic gmp-amp synthase (cgas), which belongs to the nucleotidyltransferase family, recognizes cytosolic dna and induces the type i interferon (ifn) pathway through the synthesis of the second messenger cgamp. in this study, porcine cgas (p-cgas) was identified and its tissue distribution, subcellular localization, and functions in innate immunity were characterized. the coding sequence of p-cgas is 1494 bp long, encodes 497 amino acids, and is most similar (74%) to bos taurus cgas. p-cgas mrna ... | 2015 | 25765883 |