Publications

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stlv-1 infection of papio anubis: tax sequence heterogeneity and t cell recognition.natural infection of baboons with simian t lymphotropic virus (stlv) is a potentially useful model system for study of vaccination against the human virus htlv. here we expand the number of available full-length stlv-1 baboon sequences from one to three and relate t cell responses that recognize the immunodominant tax protein to the tax sequences present in two individual baboons. continuously growing t cell lines were established from two baboons, 12141 and 12752. next-generation sequencing (ng ...201728724769
cellular immune responses against simian t-lymphotropic virus type 1 target tax in infected baboons.there are currently 5 million to 10 million human t-lymphotropic virus type 1 (htlv-1)-infected people, and many of them will develop severe complications resulting from this infection. a vaccine is urgently needed in areas where htlv-1 is endemic. many vaccines are best tested in nonhuman primate animal models. as a first step in designing an effective htlv-1 vaccine, we defined the cd8(+) and cd4(+) t cell response against simian t-lymphotropic virus type 1 (stlv-1), a virus closely related to ...201626984729
spontaneous malignant lymphoma and leukemia in a simian t-lymphotropic virus type i (stlv-i) antibody positive olive baboon. 19902153868
molecular and phylogenetic analyses of 16 novel simian t cell leukemia virus type 1 from africa: close relationship of stlv-1 from allenopithecus nigroviridis to htlv-1 subtype b strains.a serological survey searching for antibodies reacting with human t-cell leukemia virus type 1 (htlv-1) antigens was performed on a series of 263 sera/plasma obtained from 34 monkey species or subspecies, originating from different parts of africa. among them, 34 samples exhibited a typical htlv-1 western blot pattern. polymerase chain reaction was performed with three primer sets specific either to htlv-1/stlv-1 or htlv-2 and encompassing gag, pol, and tax sequences, on genomic dna from periphe ...200111531406
prevalence of antibodies against simian immunodeficiency virus (siv) and simian t-lymphotropic virus (stlv) in a colony of non-human primates in kenya, east africa.sera (165 samples in 1988 and 66, follow-up samples in 1989) were collected from olive baboons, african green monkeys, syke's monkeys and grey mangabeys kept in a semi-free, breeding colony at the institute of primate research (ipr) in nairobi, kenya. the levels of antibodies to simian t-lymphotropic virus (stlv) or simian immunodeficiency virus (siv), and the reactivity patterns of positive sera to various lentivirus subgroup antigens, were then determined. the results of tests using enzyme-imm ...19968729629
high prevalence of simian t-lymphotropic virus type l in wild ethiopian baboons.simian t-cell leukemia viruses (stlvs) are the simian counterparts of human t-cell leukemia viruses (htlvs). a novel, divergent type of stlv (stlv-l) from captive baboons was reported in 1994, but its natural prevalence remained unclear. we investigated the prevalence of stlv-l in 519 blood samples from wild-living nonhuman primates in ethiopia. seropositive monkeys having cross-reactive antibodies against htlv were found among 22 out of 40 hamadryas baboons, 8 of 96 anubis baboons, 24 of 50 bab ...200211799159
molecular characterization and phylogenetic analyses of a new simian t cell lymphotropic virus type 1 in a wild-caught african baboon (papio anubis) with an indeterminate stlv type 2-like serology.stlv-1 viruses are closely related to htlv-1 and infect many african monkey species. seroreactivities of monkeys infected by stlv-1 are nearly identical to those of htlv-1-infected individuals. in some cases, stlv-1 are, sequence-wise, indistinguishable from htlv-1, and cannot be separated from them on the basis of phylogenetic analyses. htlv-2-related simian viruses have been rarely reported. such stlv-2 viruses, present in african bonobo (pan paniscus), possess a genomic organization related t ...200011153087
phylogenetic analysis of simian t lymphotropic virus type i from kenyan olive baboons (papio anubis), lowland sykes monkeys (cercopithecus mitis), and vervet monkeys (cercopithecus aethiops pygerythrus). 199910357474
evolutionary inferences of novel simian t lymphotropic virus type 1 from wild-caught chacma (papio ursinus) and olive baboons (papio anubis).a serological survey of 22 wild-caught south african (transvaal) chacma baboons (papio ursinus) and eight olive baboons (papio anubis) from kenya indicates that 13 p. ursinus and one p. anubis have antibodies reacting with human t cell leukemia/lymphoma virus type 1 (htlv-1) antigens, whereas three p. ursinus had a indeterminate reactivity on western blot analysis. with six primer sets specific to either htlv-1-simian t-cell leukemia virus type 1 (stlv-1) or htlv-2 and encompassing long terminal ...19989813204
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