| [modification of the method of differential intracellular staining of living and dead mycobacteria]. | | 1975 | 54479 |
| sepcific tubercle antigen. | identification and isolation of the specific antigen of m. tuberculosis with the aid of an antiserum against the antigen antibody complex prepared by goudie's method from the serum of tberculous patients is described. the position of the specific antigen on the disc electrophoresis column comprising four protein bands has been identified and separated. the antibody has been identified as igg. more sophisticated techniques should enable the isolation of the specific antigen in practical amounts. ... | 1976 | 62437 |
| minimum structural requirements for encephalitogen and for adjuvant in the induction of experimental allergic encephalomyelitis. | | 1978 | 74289 |
| the correlation of bacteriophage types of mycobacterium tuberculosis with guinea-pig virulence and in vitro-indicators of virulence. | among 58 isoniazid-sensitive strains of mycobacterium tuberculosis from india, burma and east africa, 23 were of phage type a, 31 of type i (intermediate), 4 of type b and none of type c. type i strains differed from type a strains in being attenuated in the guinea-pig, susceptible to h2o2, sensitive to thiophen-2-carboxylic acid hydrazide and resistant to thiacetazone and p-aminosalicylic acid; the content of strongly acidic lipids and of sulphatide lipids was low and the attenuation indicator ... | 1978 | 80440 |
| basic mechanisms of chemotherapy. | | 1979 | 92392 |
| macrophage-lymphocyte clusters in the immune response to soluble protein antigen in vitro. viii. cinephotomicrographic studies. | t cells from immune guinea-pigs produce clusters in vitro with macrophages pulsed with soluble protein antigens. the formation of clusters is antigen-specific. time-lapse cinephotomicrography was used to study the sequence of events leading to cluster formation and the kinetics of already formed clusters. the central lymphocyte attaches through a broad base to the macrophage during the first few hours of incubation. after several hours, during which the central lymphocyte is situated alone on th ... | 1979 | 94460 |
| [virulence of h37rv cultures treated with mycobacteriophages]. | | 1978 | 97663 |
| antituberculous effect of some imidazole derivatives. | | 1978 | 102862 |
| [virulence of polyresistant strains of mycobacterium tuberculosis]. | | 1978 | 103091 |
| [adjuvant activity and antigenicity of maf3 determined by the lymphocyte blastogenesis (author's transl)]. | | 1978 | 105172 |
| [persisters and chemotherapy in tuberculous infection (author's transl)]. | | 1978 | 106180 |
| [a chemical structure in tuberculous bacilli responsible for epithelioid granuloma formation (proceedings)]. | | 1979 | 118786 |
| cytochemical and biological properties of mycobacterium bovis bcg. | it was the aim of the present communication to find a simple test for a reliable discrimination of mycobacterium bovis bcg from mycobacterium tuberculosis. a total of 26 bcg strains, out of them 10 czechoslovak strains (2 lyophilized cultures of bcg of different batch, 6 strains isolated from abscesses of children after bcg-vaccination and 2 strains from fatal cases after bcg-vaccination) and 16 strains obtained from foreign laboratories, were used. of the tested characteristics a combination of ... | 1977 | 330364 |
| suppression of cell-mediated immune responses by dextran sulphate. | the effect of high molecular weight dextran sulphate (ds) on cell-mediated immune responses was studied. two criteria were used to assess cell-mediated responses, skin graft rejection and intra-dermal (i.d.) skin tests. mice receiving allografts and ds displayed a significant increase in graft survival time compared with untreated control animals. similar results were obtained when the grafted animals differed at only the h-y locus. guinea-pigs sensitized with mycobacterium tuberculosis and trea ... | 1977 | 338479 |
| [experimental study on the effect of the immune lymphocytes on the growth of tubercle bacilli in macrophages (author's transl)]. | | 1977 | 402495 |
| macrophage-lymphocyte clusters in the immune response to soluble protein antigen in vitro. iv. synergy of lymphocytes in the formation of clusters. | | 1977 | 409505 |
| [effect of acridine compounds on stopping the development of drug resistance in mycobacterium tuberculosis (an experimental study)]. | | 1977 | 411125 |
| adjuvant activities of chemically modified water-soluble substances from mycobacterium tuberculosis. | water-soluble peptidoglycan fragments extracted from the cells of two strains of mycobacterium tuberculosis var. hominis were chemically conjugated with lauric or with palmitic acid. the coupling reaction was confirmed by physicochemical procedures. the native and the fatty acid-conjugated substances were studied for their adjuvant activity in the induction of delayed type hypersensitivity (dth) reactions in guinea-pigs and on the production of circulating antibodies in the rabbit. palmitic acid ... | 1977 | 411741 |
| lesions and tuberculin sensitivity in calves inoculated with group iii mycobacterial isolates from swine, pen soil, and cattle feed. | fifteen calves, 7 to 11 months of age, were inoculated intradermally with group iii mycobacteria ---6 isolates from swine, 1 isolate from cattle feed, and 2 isolates from soil of swine farrowing pens. calves were tuberculin tested at 50 days and killed approximately 60 days after inoculation. only 1 of the cultures, that of porcine origin (93c-0), produced any lesions. there were a caseo-calcareous granuloma 3mm in diameter in the regional lymph node (left prescapular) and a granuloma at the ski ... | 1975 | 806238 |
| [effect of cycloserine and terizidon on intracellular reproduction of mycobacterium tuberculosis]. | | 1975 | 806911 |
| the use of in-vitro and in-vivo experiments with mycobacterium tuberculosis in helping to plan chemotherapy regimens. | | 1975 | 806991 |
| infection of microtus arvalis (common vole) with mycobacterium tuberculosis and mycobacterium bovis. | the aim of the study has been to ascertain whether microtus arvalis (common vole) is strongly susceptible to m. bovis but resistant to m. tuberculosis, as is the case with other members of the vole family, or whether it is susceptible to both species as demonstrated by robert koch. groups of common voles have been injected subcutaneously or intraperitoneally with varying doses of finely dispersed suspensions of a virulent strain of m. bovis or m. tuberculosis. m. bovis multiplies strongly in the ... | 1975 | 808093 |
| modified eae as an assay for immunosuppressant drugs. | | 1975 | 809779 |
| [action of mycobacteriophages in experimental tuberculosis]. | | 1975 | 810793 |
| [chemistry and biological activities of the components of mycobacterium tuberculosis]. | | 1975 | 815693 |
| reevaluation of inguinal lymph node injection for production of adjuvant arthritis in the rat. | an experiment was designed to compare the efficiency of lymph node injection for the induction of adjuvant arthritis (aa) with that of conventional footpad injection in the rat. quantitative studies revealed that the minimal dose required for induction of aa by the lymph node route is one fifth of that by the footpad route. thus, the lymph node route was found to be more efficient than the footpad method in terms of higher incidence and earlier onset of aa. ppd in freund's incomplete adjuvant wa ... | 1976 | 819381 |
| a mycobacteriology proficiency testing program using simulated sputum specimens. | the new york state department of health proficiency testing program in mycobacteriology determines the ability of a laboratory to isolate the acid-fast bacillus present in a simulated specimen and to identify the strain. until 1964 the specimens were autoclaved normal sputa seeded with mycobacteria. when mandatory testing was introduced by law in 1964, more specimens were needed. these have been prepared in simulated sputum bases, first skimmed milk, then granulated hog gastric mucin. the bases ... | 1976 | 819397 |
| [characteristics of the action of ethambutol in experimental tuberculosis]. | | 1976 | 822418 |
| [koch's bacillus in the blood and muscle of tuberculous cattle]. | | 1976 | 822481 |
| [the present significance of animal experiment and bacterial cultivation for the diagnosis of tuberculosis (author's transl)]. | | 1976 | 823540 |
| [use of isoniazid with nitrofuran and 5-nhq derivatives in experimental tuberculosis]. | | 1976 | 826902 |
| immune responses in experimental tuberculosis after bacillus calmette-guerin vaccination and challenge with h37rv. | | 1976 | 828615 |
| [pharmacological and biochemical research on the antibiotic "substance m"]. | | 1975 | 829023 |
| studies on cell-wall deficient non-acid fast variants of mycobacterium tuberculosis. | while the host-parasite relationship in tuberculosis still remains incompletely understood, there has been recent renewed interest in indications that tubercle bacilli are converted into metabolically inactive, non-acid fast (naf) granular forms in the presence of host defence mechanisms and antituberculosis drugs. the present study investigates the mechanism of induction of these naf variants in vitro and in vivo, and their ultimate pathogenicity. evidence is provided that appears to clearly in ... | 1992 | 1493235 |
| a fastidious strain of mycobacterium tuberculosis in a patient with aids. | | 1992 | 1569993 |
| limiting-dilution analysis of the frequency of myelin basic protein-reactive t cells in lewis, pvg/c and bn rats. implication for susceptibility to autoimmune encephalomyelitis. | susceptibility to experimental autoimmune encephalomyelitis (eae), which is an autoimmune disease inducible by immunization with a brain-specific antigen in complete freund's adjuvant (cfa), is different among strains. in an attempt to resolve the immune mechanisms by which the difference in susceptibility to eae is regulated, we re-estimated susceptibility of several strains of rats, and the frequency of antigen-reactive t cells in each strain was determined by limiting-dilution analysis. eae w ... | 1990 | 1689693 |
| [the effect of silicon on the tuberculous infection and immune system]. | our study showed that silicon not only injured cell membrane, cytoplasm and nucleus membrane, but also inhibited the activity of succinic dehydrogenase in monocytes and lung tissue. in such condition, the tubercle bacilli became easier to grow. the tuberculous infection was worse in guinea-pigs infused with silicon. guinea-pigs immunized by dead bcg or non-toxic tubercle bacillus h37 ra strain were shown to have some effect against pulmonary tuberculosis. | 1991 | 1819382 |
| isolation and partial characterization of major protein antigens in the culture fluid of mycobacterium tuberculosis. | five actively secreted proteins (mpt32, mpt45, mpt51, mpt53, and mpt63) and the mpt46 protein were purified to homogeneity from mycobacterium tuberculosis culture fluid and compared with proteins previously purified by ourselves and other investigators. antisera were obtained by immunization of rabbits with all of the newly isolated proteins identified to be immunogenic. two-dimensional electrophoresis of culture fluids obtained each week for 2 to 10 weeks of culturing of m. tuberculosis reveale ... | 1991 | 1898899 |
| guinea-pig alveolar macrophages kill mycobacterium tuberculosis in vitro, but killing is independent of susceptibility to hydrogen peroxide or triggering of the respiratory burst. | alveolar macrophages from the lungs of guinea-pigs that had been vaccinated, boosted and then intravenously challenged with mycobacterium microti or mycobacterium bovis bcg killed tubercle bacilli phagocytosed in vitro. the killing was modest, about 40% of phagocytosed bacilli were killed in a day, but alveolar macrophages from animals that had been vaccinated and boosted but had not received the intravenous challenge did not kill bacilli. different strains of tubercle bacilli had different degr ... | 1991 | 1910142 |
| malnutrition-induced impairment of resistance against experimental pulmonary tuberculosis. | | 1990 | 1967840 |
| lack of diagnostic value of guineapig test for tuberculosis. | | 1990 | 1978886 |
| [the value and need for a diagnostic animal experiment within the framework of tuberculosis diagnosis]. | the comparison of the results of culture and animal test for finding of mycobacteria in selected specimens, obtained in two laboratories between 1981 and 1988 shows a superiority of the animal test. taking into account adequate literature recommendations are given as well for a possible improvement of culture methods as for the indication of animal tests. | 1990 | 2124761 |
| intracisternal administration of mycobacterium tuberculosis potentiates the delayed type hypersensitivity in guinea-pigs. | the delayed type hypersensitivity (dth) was studied in guinea-pigs using the skin test. the mycobacterium tuberculosis (m. tbc)--was applied by various routes. the control group received ovalbumin in freund's incomplete adjuvant (fia) into the footpad. the first experimental group received ovalbumin in freund's complete adjuvant (fca) into the footpad. the other experimental groups always received, in addition to ovalbumin plus fia into the footpad, the m. tbc. 1. intracisternally, 2. intramuscu ... | 1990 | 2145596 |
| a carrier method for the assessment of the effectiveness of disinfectants against mycobacterium tuberculosis. | a method for testing the effect of disinfectants against mycobacterium tuberculosis was developed using glass slide carriers contaminated with myco. tuberculosis from spleens of guinea-pigs. the method was found to be useful although a greater number of colony forming units, permitting calculation of a reduction factor in the range of 10(5), is desirable. in tests with various disinfectants, alcohols were the most effective agents against myco. tuberculosis. | 1986 | 2870110 |
| an evaluation of the polyacrylamide gel electrophoresis fractionation method for the production of mycobacterium tuberculosis skin test preparations. ii. comparative skin testing on guinea-pigs. | as part of a cooperative inter-laboratory who supported project for the fractionation of mycobacterium tuberculosis skin test preparations, four fractions (designated 15, 7, 4.75 and 3.5%) were evaluated by comparative skin tests on sensitized guinea-pigs. the 7% fraction was the most potent in both homologously and heterologously sensitized animals, and the 4.75% and 3.5% gel fractions showed the lowest activity. significant levels of cross-reactivity in guinea-pigs immunized with m. bovis bcg, ... | 1986 | 3093487 |
| [biological properties of drug-sensitive mycobacterium tuberculosis]. | | 1986 | 3094003 |
| [bacteriological diagnosis within the scope of tuberculosis control]. | | 1986 | 3097969 |
| [comparative effectiveness of different methods for the microbiological study of resected pulmonary tuberculomas]. | wide-range microbiological study (bacterioscopy, inoculation, biological assays) of 114 lung tuberculomas excised from 107 patients has revealed a pronounced variability and sharply decreased viability of mycobacterial populations vegetating in caseous foci. differences in the frequency and character of the detection of mycobacterium tuberculosis and their altered forms, arising from the use of three above-mentioned methods of microbiological investigation, were noted. bacterioscopy proved to be ... | 1987 | 3115013 |
| [the role of broncho-alveolar lavage in the diagnosis of pulmonary diseases]. | | 1988 | 3141939 |
| [effect of x-ray irradiation on the biological properties of mycobacterium tuberculosis]. | | 1985 | 3933000 |
| [virulence of catalase positive mycobacterium tuberculosis with various characteristics of drug resistance]. | | 1971 | 4108217 |
| comparison between microscopical methods and cultivation for demonstration of tubercle bacilli in experimental tuberculous infection. | | 1973 | 4129857 |
| myelin basic proteins. | | 1974 | 4141035 |
| experimental allergic encephalomyelitis and cellular immunity in the lewis rat. | | 1974 | 4142415 |
| influence of heparin and protamine on enlargement of the draining lymph node during induction of eae. | | 1974 | 4142421 |
| bacterial antigens and aggregated gamma globulin in the lesions of nodular vasculitis. | | 1967 | 4164006 |
| tissue reactions in experimental animals caused by atypical mycobacteria--evaluation of pathogenicity. i. early reactions. | | 1967 | 4166170 |
| experimental skeletal tuberculosis in the guineapig. a method for producing local lesions and an autoradiographic study of their accessibility to tritium-labelled dihydrostreptomycin. | | 1967 | 4166198 |
| [effect of hypothyroidism on the course of experimental tuberculosis. i. infection with tubercle bacilli resistant to inh]. | | 1968 | 4175705 |
| [inhibitory action of mycobacterium tuberculosis immune serums on atypical strains]. | | 1966 | 4177254 |
| [immunologic and cytochemical studies of peritoneal exudate cells during phagocytosis of mycobacterium tuberculosis]. | | 1969 | 4193060 |
| the relative immunogenicity of virulent and attenuated strains of tubercle bacilli. | | 1973 | 4197231 |
| [specificity and activity of p.p.d. tuberculin from human and bovine type strains]. | | 1973 | 4197455 |
| the diagnosis of tuberculosis in cattle with special reference to bovine ppd tuberculin. | | 1973 | 4197735 |
| immunology in cutaneous leishmaniasis. | | 1973 | 4200332 |
| isolation of tuberculin skin test reactive proteins from heated culture filtrate of mycobacterium tuberculosis h37rv. | | 1974 | 4203286 |
| [forms of persistance of tuberculosis mycobacteria in healthy subjects with regard to human tuberculosis]. | | 1973 | 4205254 |
| [preparation of sputum for the demonstration of tubercle bacilli in cultures and animal tests (author's transl)]. | | 1974 | 4205732 |
| mycobacterium tuberculosis strains showing positive iron uptake. | | 1973 | 4205981 |
| [methods and value of the microbiological diagnosis of urogenital tuberculosis]. | | 1973 | 4206319 |
| relationship of delayed-type hypersensitivity and acquired cellular resistance in experimental airborne tuberculosis. | | 1974 | 4209864 |
| pulmonary tuberculosis in free-living lechwe antelope in zambia. | | 1972 | 4210442 |
| [question of bactericidal effect of a combination of maximally tolerable doses of inh, myambutol and rifadin on experimental tuberculosis]. | | 1973 | 4210992 |
| [effect of streptomycin glycyrrhizinate on vestibular function and some other pharmacologic activities]. | | 1974 | 4211075 |
| protection of rats from experimental allergic encephalomyelitis with antiserum to guinea-pig spinal cord. | | 1974 | 4212280 |
| [effect of a steady magnetic field on mycobacterium tuberculosis]. | | 1974 | 4212632 |
| the experimental induction of localised skeletal tuberculous lesions and their accessibility to streptomycin. | | 1974 | 4213894 |
| [purification and application of tuberculosis adjuvants]. | | 1974 | 4215911 |
| [morphological aspects of the infection and re-infection with m.t. (mycobacterium tuberculosis) resistant to chemo-antibiotics]. | | 1972 | 4219269 |
| [lysosome response to tuberculosis infection, evaluated on the basis of their cathepsic activity and the degradation of tuberculoproteins]. | | 1974 | 4219733 |
| [on mesenchymal metabolism in tuberculin type allergy]. | | 1966 | 4228420 |
| [studies on the specificity and antigenic composition of fractions of mycobacterium tuberculosis, bovine type, and mycobacterium fortuitum. 2. antigen-antibody reactions]. | | 1966 | 4229105 |
| [on the immunobiological effectiveness of the tuberculin parent substance (tms)]. | | 1967 | 4231356 |
| immunological adjuvants. vi. an acetylated mycobacterial adjuvant lacking competing antigenicity. | | 1971 | 4257657 |
| the restorative effect of peritoneal macrophages on delayed hypersensitivity following ionizing radiation. | | 1971 | 4273598 |
| studies on the mitogenic activity of subcellular lymphocyte fractions. | | 1972 | 4282928 |
| [research on immunity and proteinemia in silicosis. ii. effects of silica on anaphylaxis]. | | 1967 | 4298429 |
| studies on mycobacterial sensitizing fractions. iv. fractionation of components of unheated m. tuberculosis and bcg culture filtrates by successive precipitation with ch3cooh, hclo4 and ccl3cooh. | | 1969 | 4312909 |
| site ii-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of mycobacterium tuberculosis. | | 1970 | 4319595 |
| [characteristics of the mechanism of transmission of the pathogen in respiratory infections (review of the literature)]. | | 1974 | 4372804 |
| [induction of mycobacterium infection by introduction of the organisms into the lung through an intratracheal vinyl tube]. | | 1972 | 4374362 |
| further studies with isocitric dehydrogenase in experimental tuberculosis: influence of isoniazid on metabolic damage. | | 1967 | 4381693 |
| the lethal effect of long-chain fatty acids on mycobacteria. | | 1972 | 4625006 |
| experimental cutaneous leishmaniasis. ii. effects of immunosuppression and antigenic competition on the course of infection with leishmania enriettii in the guinea-pig. | | 1972 | 4625799 |
| [experimental mycobacterial infections and reinfections]. | | 1972 | 4626197 |
| [experimental study on the antitubercular activity of butomelide]. | | 1972 | 4626206 |
| tuberculin sensitization with an acidic residual protein and purified wax of tubercle bacillus. | | 1972 | 4627022 |
| helper activity of tuberculin-reactive cells on anti-hapten antibody response. | | 1972 | 4631385 |
| mycobacterium tuberculosis infection in a parrot (amazona farinosa). | | 1974 | 4814697 |
| the attenuated w-115 strain of m. tuberculosis hominis and its isoniazid-resistant variant. | | 1965 | 4954268 |