| rickettsialpox. | rickettsialpox is a member of the spotted-fever group of the rickettsioses and results from an infection with rickettsia akari. this microbe is transmitted by the bite of the house-mouse mite liponyssoides sanguineus. patents experience fevers, sweats, headaches, and a vesicular eruption over the trunk and extremities. the palms and soles are spared. an eschar results at the spot of the mite bite. tetracycline is the treatment of choice. | 1997 | 9098640 |
| rickettsia-macrophage interactions: host cell responses to rickettsia akari and rickettsia typhi. | the existence of intracellular rickettsiae requires entry, survival, and replication in the eukaryotic host cells and exit to initiate new infection. while endothelial cells are the preferred target cells for most pathogenic rickettsiae, infection of monocytes/macrophages may also contribute to the establishment of rickettsial infection and resulting pathogenesis. we initiated studies to characterize macrophage-rickettsia akari and -rickettsia typhi interactions and to determine how rickettsiae ... | 2002 | 11953398 |
| house mouse mites infesting laboratory rodents. | liponyssoides sanguineus, principal vector of rickettsia akari, infested mongolian gerbils (meriones unguiculatus) mice (mus musculus) and laboratory-reared egyptian gerbils (meriones libycus). only a few mites were present on each animal and no manifestations of disease were observed. numerous mites were present in the bedding. | 1984 | 6482381 |
| rickettsiae and hosts. | protective immunity to rickettsia tsutsugamushi in a murine model is dependent upon the development of cell mediated immunity, as demonstrated by lymphocyte transfer, production of lymphokines and -interferon by thymus-derived lymphocytes, activation of macrophages by lymphokines and demonstration of delayed-type hypersensitivity response following exposure to these organisms. infection of mice with small numbers of rickettsia typhi inoculated by a peripheral route leads to a more complex patter ... | 1985 | 2408453 |
| macrophages in resistance to rickettsial infections: genetic analysis of susceptibility to lethal effects of rickettsia akari infection and development of activated, cytotoxic macrophages in a and b10.a mice. | susceptibility to lethal effects of rickettsia akari varies among mouse strains. although most strains are resistant, a/j mice are extremely sensitive (10,000-fold difference in ld50 between resistant and sensitive strains). in contrast to most strains of mice, a/j mice also fail to develop activated, tumoricidal macrophages after any of several in vivo or in vitro treatments. are susceptibility to r. akari and inability to develop activated, cytotoxic macrophages in the a/j strain causally rela ... | 1982 | 6896718 |
| macrophages in resistance to rickettsial infection: susceptibility to lethal effects of rickettsia akari infection in mouse strains with defective macrophage function. | | 1980 | 6893426 |
| rickettsialpox; a newly recognized rickettsial disease; recovery of rickettsia akari from a house mouse (mus musculus). | | 1947 | 20342271 |
| serologic evidence of a rickettsia akari-like infection among wild-caught rodents in orange county and humans in los angeles county, california. | we detected antibodies reactive with rickettsia akari, the etiologic agent of rickettsialpox in humans and in 83 of 359 (23%) rodents belonging to several species, collected in orange county, ca. reciprocal antibody titers >1:16 to r. akari were detected in native mice and rats (peromyscus maniculatus, p. eremicus, and neotoma fuscipes) and in old world mice and rats (mus musculus, rattus rattus, and r. norvegicus), representing the first time that antibodies reactive with this agent have been d ... | 2007 | 18260508 |
| hepatitis in association with rickettsialpox. | rickettsialpox is an acute, self-limited, febrile illness caused by rickettsia akari and transmitted by liponyssoides sanguineus, a mite that infests the common house mouse, mus musculus. liver involvement in rickettsialpox has received little attention, although hepatitis has been reported in several other rickettsial infections. in this report, we describe two patients with rickettsialpox who had acute hepatitis that resolved completely. in the appropriate clinical setting, rickettsialpox shou ... | 2008 | 18171106 |
| effect of interferon and interferon inducers on infections with a nonviral intracellular microorganism, rickettsia akari. | the effect of mouse interferon (if) on the multiplication of rickettsia akari in homologous (l-929) cell cultures and the effect of if inducers on r. akari infection in mice were investigated. there was a reduction in the proportion of cells containing rickettsiae in if-treated cultures and in the yield of rickettsiae from these cultures, as compared with those from infected cultures without if. trypsin treatment and heating for 1 hr at 65 c destroyed this antirickettsial activity of the if prep ... | 1971 | 16558061 |
| urban zoonoses caused by bartonella, coxiella, ehrlichia, and rickettsia species. | the last half of the 20th century witnessed an increase in the occurrence and recognition of urban zoonoses caused by members of the genera bartonella, coxiella, ehrlichia, and rickettsia, all traditionally considered to be members of the family rickettsiaceae. in recent years, new human pathogens (bartonella elizabethae, bartonella henselae, and rickettsia felis) have been recognized in urban environments. other newly recognized pathogens (ehrlichia chaffeensis and ehrlichia phagocytophila in t ... | 2001 | 12653141 |
| host defenses in experimental rickettsialpox: genetics of natural resistance to infection. | the genetic basis for natural resistance to lethal infection with rickettsia akari was studied in over 25 inbred strains, inbred hybrids, and outbred stocks of mice. inbred mice infected intraperitoneally with the kaplan strain of r. akari demonstrated three levels of response, susceptible (c3h/hej), intermediate (a/hej, a/j, a/wysn, balb/cdub, balb/cj, and sjl/j), and resistant (akr/j, al/n, balb/cann, balb/cncr1br, c3h/hen, c57bl/6j, c57l/j, cba/j, dba/2j, and swr/j). no correlation was eviden ... | 1980 | 7380561 |