Publications

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seroprevalence of rickettsial infection in commensal rodents and shrews trapped in the bangkok metropolitan area.murine typhus and scrub typhus are important human rickettsial diseases in thailand. small mammals, including many species of rodents and shrews, serve as the reservoir host of rickettsial diseases. rickettsia typhi can be transmitted to humans by fleas causing murine typhus, while infection with orientia tsutsugamushi causing scrub typhus in humans is transmitted by chiggers. the prevalence of rickettsial infection depends on the geographic area. the seroprevalence of antibody to r. typhi and o ...200312924799
seroepidemiological survey of rodents collected at a u.s. military installation, yongsan garrison, seoul, republic of korea.a seroepidemiological study of selected rodent-borne diseases (hantavirus [seoul [seo] virus], scrub typhus [orientia tsutsugamushi], murine typhus [rickettsia typhi], and leptospirosis [leptospira interrogans]), as part of the u.s. military rodent surveillance and control program, was conducted from 2001 through 2005 at yongsan garrison, seoul, republic of korea. rodents were collected to determine the prevalence of rodent-borne diseases at a u.s. military installation in an urban environment. ...200717691691
rickettsia typhi infection in wild rodents from central spain.when sera from 218 rodents captured in two provinces of central spain were tested, by indirect immunofluorescence, for antibodies to rickettsia typhi, 46 (21.1%) were found to be positive, at titres between 1:20 and 1:320. the seropositives included rodents of each of the five species collected: mus musculus, mus spretus, apodemus sylvaticus, rattus rattus and rattus norvegicus. rickettsia typhi infection appears to be common and widespread among the rodents of central spain.200312831526
urban zoonoses caused by bartonella, coxiella, ehrlichia, and rickettsia species.the last half of the 20th century witnessed an increase in the occurrence and recognition of urban zoonoses caused by members of the genera bartonella, coxiella, ehrlichia, and rickettsia, all traditionally considered to be members of the family rickettsiaceae. in recent years, new human pathogens (bartonella elizabethae, bartonella henselae, and rickettsia felis) have been recognized in urban environments. other newly recognized pathogens (ehrlichia chaffeensis and ehrlichia phagocytophila in t ...200112653141
rickettsia-macrophage interactions: host cell responses to rickettsia akari and rickettsia typhi.the existence of intracellular rickettsiae requires entry, survival, and replication in the eukaryotic host cells and exit to initiate new infection. while endothelial cells are the preferred target cells for most pathogenic rickettsiae, infection of monocytes/macrophages may also contribute to the establishment of rickettsial infection and resulting pathogenesis. we initiated studies to characterize macrophage-rickettsia akari and -rickettsia typhi interactions and to determine how rickettsiae ...200211953398
prevalence of vectors of the spotted fever group rickettsiae and murine typhus in a bedouin town in israel.a survey of the vectors of spotted fever group rickettsiae and of murine typhus was carried out in rahat, a bedouin town in the negev desert, where the diseases are endemic. houses with known cases of spotted fever group rickettsiae or murine typhus were compared with those without reported clinical cases. a neighboring jewish community, lehavim, where no cases of spotted fever group rickettsiae and murine typhus were reported in recent years, was used as a control. in the houses of patients wit ...200111372975
detection of rickettsia felis and rickettsia typhi and seasonal prevalence of fleas collected from small mammals at gyeonggi province in the republic of korea.abstract fleas were collected from live-captured small mammals to identify flea-borne pathogens, host associations, and seasonal prevalence of flea species, as part of the 65th medical brigade rodent-borne disease surveillance program at 20 military installations and training sites, gyeonggi province, republic of korea, 2005-2007. a total of 1251 fleas were recovered from 2833 small mammals. apodemus agrarius, the striped field mouse, accounted for 93.1% (2,637/2,833) of all small mammals captur ...201121612536
detection of rickettsia typhi and seasonal prevalence of fleas collected from small mammals in the republic of korea.fleas were collected from live-captured small mammals to identify potential flea-borne pathogens, seasonal prevalence of flea species, and host preference as part of the us military rodent-borne diseases surveillance program conducted at one us military installation and 10 military training sites, northern gyeonggi province, republic of korea. during 2003-04, 948 fleas (563 females and 385 males) were recovered from 2,742 small mammals (seven rodent and one insectivore species). apodemus agrariu ...201020090029
the role of rodents as reservoirs for some diseases in new reclaimed areas in north sinai.in a trial to determine the role of sinai rodents as reservoirs to rickettsial diseases, the ifa technique was used to detect the presence of r. typhi and spotted fever group in blood of some commensal and wild rodent species collected in sinai during the last five years (1985-1989). out of 277 rattus spp. collected in el arish (47.3%) were positive to r. typhi and only (5.9%) of 35 mus musculus were positive to r. typhi. as for gerbillus spp. only (1.5%) of 206 animals were positive for r. typh ...19911908502
rickettsiae and hosts.protective immunity to rickettsia tsutsugamushi in a murine model is dependent upon the development of cell mediated immunity, as demonstrated by lymphocyte transfer, production of lymphokines and -interferon by thymus-derived lymphocytes, activation of macrophages by lymphokines and demonstration of delayed-type hypersensitivity response following exposure to these organisms. infection of mice with small numbers of rickettsia typhi inoculated by a peripheral route leads to a more complex patter ...19852408453
studies of the rickettsial plaque assay technique.a plaque assay system for pathogenic rickettsiae, which utilizes primary chick embryo tissue cultures, is described. it proved to be a highly reproducible measure of infectiousness for rickettsia rickettsi and r. typhi, which were employed in most studies; as well as for r. canada, r. prowazeki, r. sibirica, r. akari, r. conori, and coxiella burneti. plaque-forming units (pfu) were compared to direct rickettsial counts and to 50% infectious dose (id(50)) values for embryonated eggs, mice, and gu ...19724629250
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