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clinical features of human infection with scedosporium inflatum.we report on 17 australian cases of human infection or colonization with scedosporium inflatum. the spectrum of clinical manifestations was similar to that in infection caused by scedosporium apiospermum. the patients were classified into three groups. four immunocompetent patients who presented with localized infections of a joint, nail bed, eye, or sphenoidal sinus made up the first group. our first case, in a boy with posttraumatic septic arthritis, responded to surgical drainage with amphote ...19921534693
[scedosporium apiospermum infection in a patient with myelomonocytic leukemia presenting as lympho-cutaneous sporotrichosis].63 year old patient is presented with myelo-monocytic leukemia, in whom subcutaneous nodules developed at the lower limb, spreading along the lymph vessels, and partly ulcerating. by mycologic investigation scedosporium apiospermum was disclosed. attention is drawn to human infections brought about by opportunistic scedosporium species.19947970657
typing of scedosporium apiospermum by multilocus enzyme electrophoresis and random amplification of polymorphic dna.the genetic diversity among epidemiologically unrelated strains of the human pathogenic fungus scedosporium apiospermum or its teleomorph, pseudallescheria boydii, from different areas in europe, was investigated by multilocus enzyme electrophoresis (mlee) and random amplification of polymorphic dna (rapd). fourteen enzyme activities were analysed by starch gel electrophoresis, corresponding to 27 polymorphic loci and 43 iso-enzymes. among the enzymes studied, propionate esterase, carboxyl ester ...200111599744
amphotericin b lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against scedosporium prolificans and scedosporium apiospermum.scedosporium prolificans and scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. the combined effects of deoxycholate amphotericin b, amphotericin b lipid complex and liposomal amphotericin b with human polymorphonuclear leucocytes (pmns) in damaging hyphae of these fungi were evaluated by xtt assay. amphotericin b lipid complex displayed a significant additive effect with pmns against both scedosporium species (22% for s. ...200212461027
caspofungin-mediated beta-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against aspergillus and non-aspergillus hyphae.we investigated whether caspofungin and other echinocandins have immune-enhancing properties that influence human polymorphonuclear neutrophil (pmn)-mediated mold hyphal damage.200818500936
proteins and peptidases from conidia and mycelia of scedosporium apiospermum strain hlpb.the conidia-mycelia transformation is an essential step during the life cycle of the fungal human pathogens of the pseudallescheria boydii complex. in the present study, we have analyzed the protein and peptidase profiles in two distinct morphological stages, conidia and mycelia, of scedosporium apiospermum sensu stricto. proteins synthesized by the mycelia, migrating at the ranges of 62-48 and 22-18 kda, were not detected from the conidial extract. conidia produced a single cellular peptidase o ...200918726166
osteomyelitis and discospondylitis due to scedosporium apiospermum in a dog.a 6-year-old, 30-kg, female german shepherd dog, living in a leishmaniasis enzootic area, was presented with a severe rear limb motor disorder and a medical history of acute onset of fever. routine hematology indicated neutrophilia. spinal survey radiographs were consistent with osteomyelitis and discospondylitis. because of the poor clinical prognosis and the painful nature of the lesions, the dog was euthanized at the owners' request. at necropsy, t13-l1 vertebrae had large areas of necrosis w ...200919139512
human and animal isolates of pseudallescheria boydii and scedosporium species, from melbourne, australia, 1977-1995.from 1977 to 1995, 25 of the fungal cultures referred to the microbiological diagnostic unit public health laboratory at the university of melbourne, victoria, australia were identified as scedosporium apiospermum, pseudallescheria boydii, or scedosporium prolificans. these cultures had been isolated from 22 patients at metropolitan hospitals and three animals at veterinary institutes. eight of the human isolates were identified as p. boydii, 11 as s. apiospermum and three as s. prolificans. iso ...201020492531
[case of scedosporium apiospermum cutaneous soft tissue infection treated with voriconazole].a 69-year-old man treated with corticosteroids and immunosuppressive agents for acutely exacerbated interstitial pneumonia was found to have an ingrown nail in the left big toe and that suppurated despite treatment by dermatologists. culture of the pus expressed from the toe yielded scedosporium apiospermum. the patient suffered liver dysfunction a few days later when treated with intravenous voriconazole (vrcz), which was discontinued due to the high plasma vrcz concentration. discrete erythema ...200818411765
unusual pharmacokinetics of intravitreal and systemic voriconazole in a patient with scedosporium apiospermum endophthalmitis.in this paper, we report a case of a post-traumatic scedosporium endophthalmitis treated with a posterior vitrectomy, followed by intravitreal injections and systemic voriconazole. this is the second documented case of s. apiospermum endophthalmitis treated with voriconazole and the first case with intravitreal injections of voriconazole. a 29-year-old man developed endophthalmitis after being struck in the left eye by a chip from a swimming pool pump. despite 3 weeks of prophylactic antibiother ...200818370878
polycytella hominis is a mutated form of scedosporium apiospermum.pcr amplification and sequencing of two separate regions of the nuclear ribosomal repeat region revealed that polycytella hominis, a hyphomycete isolated from a human case of mycetoma, was genetically indistinguishable from scedosporium apiospermum (the anamorph of pseudallescheria boydii). these organisms also exhibited remarkably similar susceptibility profiles to common antifungal agents. p. hominis is thus likely to be a mutant of s. apiospermum showing abnormalities of sporulation, for whic ...200616805091
human phagocytic cell responses to scedosporium apiospermum (pseudallescheria boydii): variable susceptibility to oxidative injury.scedosporium apiospermum (pseudallescheria boydii) is an emerging opportunistic filamentous fungus that causes serious infections in both immunocompetent and immunocompromised patients. to gain insight into the immunopathogenesis of infections due to s. apiospermum, the antifungal activities of human polymorphonuclear leukocytes (pmns), mononuclear leukocytes (mncs), and monocyte-derived macrophages (mdms) against two clinical isolates of s. apiospermum were evaluated. isolate sa54a was amphoter ...200314573669
antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to scedosporium prolificans and scedosporium apiospermum.scedosporium prolificans and scedosporium apiospermum (pseudallescheria boydii) cause pulmonary and disseminated infections refractory to most currently used antifungal agents in immunocompromised patients. we therefore investigated the potential antifungal activities of the triazoles itraconazole (itc), voriconazole (vrc), and posaconazole (psc) in combination with human polymorphonuclear leukocytes (pmns) against the hyphae of these fungal pathogens. a colorimetric assay with (2,3-bis[2-methox ...200212069979
[scedosporiosis of the brain with fatal outcome after traumatizatio of the foot. case report].a 33 year old german man suffered from a wound of his foot after an accident. he developed an osteomyelitis. from wound probes scedosporium apiospermum could be isolated for several times. some weeks later a cerebral lesion could be diagnosed. the lesion was extirpated and again s. apiospermum could be cultured from the cerebral probes. a few weeks later the patient died and some new cerebral lesions could be diagnosed by ct-scan.200011291574
amphotericin b responsive scedosporium apiospermum infection in a patient with acute myeloid leukaemia.a 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. scedosporium apiospermum was isolated from the lesion, which resolved rapidly on treatment with intravenous amphotericin b despite being resistant in vitro to this agent. this observation suggests that sensitivity testing of s apiospermum should be interpreted with caution and that clinical response may be a better indicator of outcome.19968666698
scedosporium inflatum, an emerging pathogen.the salient morphologic and physiologic characteristics of 18 isolates of scedosporium inflatum, a newly reported human pathogen, were compared with those of the morphologically similar fungi scedosporium apiospermum, scopulariopsis brevicaulis, and scopulariopsis brumptii. the formation by s. inflatum of annelloconidia in wet clumps at the apices of annellides with swollen bases was found to be the most useful characteristic in differentiating this potential pathogen.19883356789
[a case of lung scedosporiosis successfully treated with monitoring of plasma voriconazole concentration level].a 71-year-old man was referred because of fever and productive cough. his chest radiograph showed a large cavitary mass with an intracavitary mycetoma-like lesion in the left middle lung field. we undertook bronchoscopy and ct-guided biopsy, and both bronchial lavage fluid culture and ct-guided biopsy culture revealed scedosporium apiospermum. on a diagnosis of lung scedosporiosis, he was treated with 200 mg/day voriconazole for 2 months, but his symptoms did not improve. measurement of the plas ...201121688649
multiple scedosporium apiospermum brain abscesses after near-drowning successfully treated with surgery and long-term voriconazole: a case report.scedosporium apiospermum is an emerging fungal pathogen, increasingly recognised as a cause of infection not only in immunocompromised, but also in non-immunodeficient patients. we present the case of an immunocompetent 21-year-old thai man who experienced recurrent ruptured mycotic aneurysms and developed multiple s. apiospermum brain abscesses following aspiration of polluted water. a combination of surgery and voriconazole was effective in this difficult-to-treat case. voriconazole penetrated ...200717944716
inteferon gamma and granulocyte-macrophage colony-stimulating factor augment the antifungal activity of human polymorphonuclear leukocytes against scedosporium spp.: comparison with aspergillus spp.while aspergillus spp. have been the most frequent filamentous fungi causing infections in immunocompromised patients, scedosporium spp. are emerging as life-threatening pathogens. we studied the effects of interferon gamma (ifn-gamma) and granulocyte-macrophage colony-stimulating factor (gm-csf) alone or combined on the antifungal activities of human polymorphonuclear leukocytes (pmn) against scedosporium apiospermum and scedosporium prolificans. we paralleled these activities to those against ...200516010852
otitis caused by scedosporium apiospermum in an immunocompetent child.scedosporium apiospermum (pseudallescheria boydii) is a ubiquitous saprophytic mold. it is considered an infrequent but important and emerging human pathogen, mostly in immunocompromised hosts. otomycosis secondary to s. apiospermum is extremely rare. we report an 8-year-old immunocompetent male who developed otitis media and otitis externa from s. apiospermum, which was successful treated with combination of surgical debridement and topical clotrimazole therapy. a brief literature review of inf ...200415183592
an atypical isolate of scedosporium apiospermum from a purulent meningitis in man. 19817197398
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