Publications

structure and cytopathic effects of nelson bay virus.	a virus isolated from a flying fox (pteropus poliocephalus) has a morphology similar to that of reoviruses. however, unlike the reoviruses, this virus has a rapid cytopathic effect, causing cell fusion, vacuolization of the cytoplasm, and an unusual nuclear degeneration. immunofluorescence indicates that viral antigen is distributed through both nucleus and cytoplasm. viral maturation appears to take place in discrete cytoplasmic factories, and there is no apparent involvement of spindle tubules ...	1970	4097231
bats: important reservoir hosts of emerging viruses.	bats (order chiroptera, suborders megachiroptera ["flying foxes"] and microchiroptera) are abundant, diverse, and geographically widespread. these mammals provide us with resources, but their importance is minimized and many of their populations and species are at risk, even threatened or endangered. some of their characteristics (food choices, colonial or solitary nature, population structure, ability to fly, seasonal migration and daily movement patterns, torpor and hibernation, life span, roo ...	2006	16847084
pulau virus; a new member of the nelson bay orthoreovirus species isolated from fruit bats in malaysia.	after the outbreak of nipah virus (niv) in 1998-99, which resulted in 105 human deaths and the culling of more than one million pigs, a search was initiated for the natural host reservoir of niv on tioman island off the east coast of malaysia. three different syncytia-forming viruses were isolated from fruit bats on the island. they were nipah virus, tioman virus (a novel paramyxovirus related to menangle virus), and a reovirus, named pulau virus (puv), which is the subject of this study. puv di ...	2006	16205863
mouse fibroblast l929 cells are less permissive to infection by nelson bay orthoreovirus compared to other mammalian cell lines.	in recent years, bats have been identified as a natural reservoir for a diverse range of viruses. nelson bay orthoreovirus (nbv) was first isolated from the heart blood of a fruit bat (pteropus poliocephalus) in 1968. while the pathogenesis of nbv remains unknown, other related members of this group have caused acute respiratory disease in humans. thus the potential for nbv to impact human health appears plausible. here, to increase our knowledge of nbv, we examined the replication and infectivi ...	2015	25748429
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590