Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a restriction endonuclease from staphylococcus aureus. | a specific endonuclease, sau 3ai, has been partially purified from staphylococcus aureus strain 3a by deae-cellulose chromatography. the enzyme cleaves adenovirus type 5 dna many times, sv40 dna eight times but does not cleave double-stranded phi x174 dna. it recognizes the sequence (see article) and cleaves as indicated by the arrows. evidence is presented that this enzyme plays a role in the biological restriction-modification system of staphylococcus aureus strain 3a. | 1976 | 1005115 |
| epizootic staphylococcal infections in subhuman primates after surgical operation. | in late october, 1974, staphylococcus aureus postoperative wound infection was recorded in a nonhuman primate (macaca mulatta) which had recently undergone surgical operation. infection in a second monkey appeared approximately 2 weeks later, and a clustering of 6 cases appeared over the next 3-week period. the clinical spectrum included septicemia in 2 monkeys and skin infection at the surgical incision site of several others. investigation revealed a uniform and consistent association of a pha ... | 1976 | 132881 |
| neonatal staphylococcal scalded skin syndrome: massive outbreak due to an unusual phage type. | a massive outbreak of the staphylococcal scalded skin syndrome due to an organism with an unusual phage pattern, occurred during a 115-day period and involved 68 newborns. generalized exfoliative dermatitis was seen in 24 babies, and staphylococcus aureus was isolated from 23. fourteen isolates were phage typed, with 13 reported as the epidemic strain 29/79/80/3a/3c/54/75. eight babies had generalized scarlatiniform eruption without exfoliation (staphylococcal scarlet fever). cultural data were ... | 1980 | 6447271 |
| purification of liver microsomal cytochrome p-450 isozymes 3a and 6 from imidazole-treated rabbits. evidence for the identity of isozyme 3a with the form obtained by ethanol treatment. | two forms of cytochrome p-450 have been purified to electrophoretic homogeneity from hepatic microsomes of rabbits treated with imidazole. several criteria indicate that the cytochrome of higher electrophoretic mobility is identical with ethanol-inducible isozyme 3a. "imidazole-3a" and "ethanol-3a" exhibit the same chromatographic characteristics and have identical electrophoretic mobilities upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis. furthermore, the two protein preparations ... | 1984 | 6427601 |
| [restriction endonuclease sau 6782]. | data are described on identification, isolation and purification of restricting endonuclease sau 6782 as well as on estimation of the enzyme recognition site. conditions were developed for growing of staphylococcus aureus 6782 strain, which enabled to produce a maximal yield of the restricting activity containing minimal level of nucleases. the procedure for isolation and purification of restrictase sau 6782 involved affinity chromatography on blue sepharose and cation exchange chromatography on ... | 1985 | 3004036 |
| bacteriophages in l form of staphylococcus aureus. | lysogenicity and phage typability of staphylococcus aureus l-form cells are described. spontaneously produced phages were found in thin sections of s. aureus l colonies. the dimensions of the tail and head resemble those of the morphological group biii2 (t. krzywy, i. durlakowa, a. kucharewcz-krukowska, s. krynski, and s. slopek, zentralbl. bakteriol. mikrobiol. hyg. abt. 1 orig. reihe a 250:287-295, 1981). phages 3a and 3c of the international typing set lysed both the bacillary and l form of s ... | 1985 | 2931422 |
| outbreak of staphylococcal infection in two hospital nurseries traced to a single nasal carrier. | in late january and early february 1983, an outbreak of skin infections (7 of 145 infants) caused by a penicillin/erythromycin resistant strain of staphylococcus aureus (sa), phage type 3a/3c, occurred in our newborn nursery. a week following the first cluster of infections, another nursery outbreak due to sa with the same antibiogram occurred in a nearby community hospital (11 of 114 infants). subsequently, a second cluster of infections with the same sa was identified at our nursery. the epide ... | 1986 | 3640736 |
| immunoultrastructural studies of human nk cells: ii. effector-target cell binding and phagocytosis. | the binding of nk cells to a target cell appears to be a necessary step for nk cell-mediated cytolysis. in this report, we demonstrated effector-target binding by immunoelectron microscopy by using monoclonal antibodies against nk cells (leu-7, leu-11a) and t-cell subsets (leu-2a/t8, leu-3a/t4). the surfaces of nk and k562 cells were characterized by antitransferrin receptor antibody and various lectins. in addition, the controversial phagocytic activity of nk cells was studied by incubation of ... | 1987 | 3578843 |
| can the association of athymic mice (han:nmri-nu) with staphylococcus sciuri prevent infection with staphylococcus aureus? experiences from a field study. | an attempt was made to prevent the introduction of staphylococcus aureus into a newly established colony of han:nmri-nu mice by means of preassociation with the rodent-specific staphylococcus sciuri. despite the successful colonization of the mice with s. sciuri the establishment of s. aureus into the colony was not impeded, and abscesses were observed with an increasing frequency until the end of the study. random samples revealed the phage pattern 3a/3c/55/71 or very similar ones. a caretaker ... | 1989 | 2523626 |
| nontypeable bacteriophage patterns of methicillin-resistant staphylococcus aureus involved in a hospital outbreak. | of 93 strains of staphylococcus aureus isolated from inpatient wards of ismailia general hospital, 48 (51%) were proven to be methicillin resistant (mr). of these mr s. aureus strains, 44 were isolated from patients and 4 were isolated from healthy carriers, who were newly arrived interns working in the same wards. bacteriophage patterns of mr s. aureus were identified by using routine test dilution (rtd) and 100-fold dilutions (100 rtd) of phages. of these 48 strains, 37 (75%) (33 from patients ... | 1989 | 2531157 |
| [studies on reaction and antibacterial activity of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazole with several electrophilic reagents]. | upon treatment of 1-aryl-4-ethoxycarbonyl-5-amino-1,2,3-triazoles (1) with excess acetic acid, acetic anhydride, acetyl chloride, benzoyl chloride, formamide, etc., fourteen new derivatives of 1 were obtained in good yields, such as, 1-h-4-ethoxycarbonyl-5-arylamino-1,2,3-triazoles (2b-d), 1-rco-4-ethoxycarbonyl-5-arylamino-1,2,3-triazoles (3a-d), 1-aryl-4-ethoxycarbonyl-5-acetylamino-1,2,3-triazoles (4a-d) and 1-formoyl-4-ethoxycarbonyl-5-p-nitrophenylamino-1,2,3-triazole (5a), 1-benzoyl-4-etho ... | 1991 | 1823974 |
| changing patterns among the subgroups of strains of staphylococcus aureus of phage group ii in danish hospitals from 1961-91. | during the period 1961-91 a total of 567,635 strains of staphylococcus aureus from hospitalized patients in denmark have been characterized according to their antibiotic resistance, site of isolation and phage type. strains of phage group ii (typed by the phages 3a, 3c, 55 and 71) have been analysed further. the occurrence of group ii strains was relatively constant (approximately 16%) from 1961 until 1983. since then the frequency of group ii strains increased; in 1991 they accounted for 22.7% ... | 1994 | 8119367 |
| pyridonecarboxylic acids as antibacterial agents. vii. synthesis and structure-activity relationship of amino- and hydroxyl-substituted 7-cycloalkyl and 7-vinyl derivatives of 1-cyclopropyl-6-fluoro-4-quinolone-3- carboxylic acid. | novel c(7)-derivatives of 1-cyclopropyl-6-fluoro-4-quinolone carboxylic acid (3a-o) have been synthesized and evaluated for in vitro antibacterial activity. compounds 3e (3-aminocyclobutyl), 3g (1-aminocyclopropyl), 3m ((2-aminomethyl)vinyl), and 3o ((1-aminomethyl)vinyl) showed significant inhibitory activity, comparable to that of ciprofloxacin, against gram-negative bacteria including p. aeruginosa. a good pharmacokinetic profile (serum and brain concentrations and urinary recovery) was obtai ... | 1994 | 7805130 |
| colonization of rabbits with staphylococcus aureus in flocks with and without chronic staphylococcosis. | rabbits of 19 rabbitries were examined for the presence of staphylococcus aureus in nine different body sites. seven rabbitries experienced epidemically spreading signs of staphylococcosis while the other 12 rabbitries did not. s. aureus was isolated in all seven flocks that suffered from chronic problems of staphylococcosis and in 11 of the 12 clinically healthy flocks. the mean percentage of infected animals in these two groups was 90 and 43.3%, respectively. s. aureus was isolated from all bo ... | 1999 | 10392776 |
| evolution and function of the neisserial dam-replacing gene. | phase variation through slippage-like mechanisms involving homopolymeric tracts depends in part on the absence of dam-methylase in several pathogenic isolates of neisseria meningitidis. in dam-defective strains drg (dam-replacing gene), flanked by pseudo-transposable small repeated elements (sres), replaced dam. we demonstrate that drg encodes a restriction endonuclease (nmebii) that cleaves 5'-gmeatc-3'. drg is also present in 50% of neisseria lactamica strains, but in most of them it is inacti ... | 2001 | 11334887 |
| neonatal staphylococcal scalded skin syndrome complicating ileal atresia. | staphylococcal scalded skin syndrome is a toxin mediated staphylococcal infection, the toxin produced by staphylococcus aureus type 2 phage types (55,71,3a,3b,3c). there is a generalized tender erythema which commences on the head and neck, accompanied by fever, irritability, continuous cry and miserable look. the erythema is followed by cleavage of the upper epidermis in a large sheets mainly in the head, neck and the flexures, with formation of bullae (nikolsky sign). it is most common in infa ... | 2003 | 12847634 |
| synthesis of certain substituted quinoxalines as antimicrobial agents (part ii). | several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5h)-thione (6), 4-(arylidenehydrazino)1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives wer ... | 2003 | 12643584 |
| synthesis and evaluation of the antibacterial and antitubercular activity of some n1-aral-n4-(3-chloro-4-fluorophenyl)thiosemicarbazones and their copper(i) complexes. | new n1-aral-n4- (3-chloro-4-fluorophenyl)thiosemicarbazones (2a-h) and their cu(i) complexes (3a-h) have been prepared and characterized by elemental analysis and spectral methods (ir and 1h-nmr). thiosemicarbazones 2a-h bind to copper(i) as bidentate ligand via nitrogen and thione sulphur centers to afford 3a-h. both ligands and their complexes are screened against escherichia coli (national collection of type culture 10418) and staphylococcus aureus (national collection of type culture 5571) t ... | 2005 | 15787278 |
| synthesis and biological evaluation of some pyrazolinylpyridines and pyrazolylpyridines. | various new 2-(1'-acetyl-5'-substituted-aryl-2'-pyrazolin-3'-yl)aminopyridines (3a-3e) and 2-(1'-phenyl 5'-substituted aryl-2'-pyrazol-3'-yl)aminopyridines (4a-4e) have been derived from 2-(substituted benzylidenylacetyl)aminopyridines (2a-2e). the structure of these compounds have been elucidated by elemental and spectral (ir, 1h-nmr, mass) analysis. furthermore, above said compounds were evaluated for their insecticidal, antifungal, and antibacterial activities. compound 4b 2-[1'-phenyl-5'-(o- ... | 2006 | 16411173 |
| antibacterial galloylated alkylphloroglucinol glucosides from myrtle (myrtus communis). | an investigation of the polar glycosidic fraction from the leaves of myrtle afforded four galloylated nonprenylated phloroglucinol glucosides (3a-d) related to the endoperoxide hormone g3 (4) in terms of structure and biogenesis. despite their close similarity, significant antibacterial activity was shown only by one of these compounds (3b, gallomyrtucommulone b), while the g3 hormone (4) was inactive. | 2006 | 16499325 |
| rapid synthesis of sulfone derivatives as potential anti-infectious agents. | an original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. this eco-friendly methodology conducted in 30min led to desired products with good yields. the sulfones (4a and 4b) were obtained via the reaction of 3a with the corresponding halo-derivatives in the presence of sodium hydride. all compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two gram positive, and two gram ne ... | 2007 | 17320245 |
| organoiodine(iii) mediated synthesis of 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines as antibacterial agents. | nine 3,9-diaryl- and 3,9-difuryl-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidines (3a-i) have been synthesized by the oxidation of bis-2,4-pyrimidinylhydrazones of various araldehydes and furfural with 2equiv of iodobenzene diacetate (ibd) in dichloromethane and tested in vitro for their antibacterial activity. three compounds, namely 3,9-di-(4'-fluorophenyl)-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidine (3f), 3,9-di-(4'-nitrophenyl)-bis-1,2,4-triazolo[4,3-a][4,3-c]pyrimidine (3g) and 3,9-di-(5'-nitro-2 ... | 2007 | 17222483 |
| an efficient synthesis and reactions of novel indolylpyridazinone derivatives with expected biological activity. | reaction of 4-anthracen-9-yl-4-oxo-but-2-enoic acid (1) with indole gave the corresponding butanoic acid 2. cyclocondensation of 2 with hydrazine hydrate, phenyl hydrazine, semicarbazide and thiosemicarbazide gave the pyridazinone derivatives 3a-d. reaction of 3a with pocl(3) for 30 min gave the chloropyridazine derivative 4a, which was used to prepare the corresponding carbohydrate hydrazone derivatives 5a-d. reaction of chloropyridazine 4a with some aliphatic or aromatic amines and anthranilic ... | 2007 | 17693951 |
| synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1h-pyrazoles. | 2-acetylbenzofuran 1 on treatment with substituted aldehydes affords the corresponding chalcones 2a-c. treatment of the chalcones with nitromethane under michael addition condition furnished the corresponding michael adducts 3a-c. cyclocondensation of the chalcones 2a and 2b with thiosemicarbazide under basic refluxing conditions gave 3-(benzofuran-2-yl)-5-(4-aryl)-4,5-dihydropyrazole-1-carbothioamides 4a,b. the pyrazolines 7a-d were synthesized by treating 4a,b with phenacyl bromides in refluxi ... | 2009 | 18995932 |
| novel benzyl-substituted n-heterocyclic carbene-silver acetate complexes: synthesis, cytotoxicity and antibacterial studies. | from the reaction of 1-methylimidazole (1a), 4,5-dichloro-1h-imidazole (1b(i)) and 1-methylbenzimidazole (1c) with p-cyanobenzyl bromide (2a), non-symmetrically substituted n-heterocyclic carbene (nhc) [(3a-c)] precursors, 5,6-dimethyl-1h-benzimidazole (1d) and 4,5-diphenyl-1h-imidazole (1e) with p-cyanobenzyl bromide (2a) and benzyl bromide (2b), symmetrically substituted n-heterocyclic carbene (nhc) [(3d-f)] precursors were synthesised. these nhc-precursors were then reacted with silver(i) ace ... | 2010 | 21135954 |
| synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents. | some new 3-acetyl-5-(3-chloro-1-benzo[b]thiophen-2-yl)-2-substituted phenyl-2,3-dihydro-1,3,4-oxadiazoles and 2-(3-chloro-1-benzo[b]thiophen-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles have been synthesized and evaluated for antimicrobial activity. initially, 3-chloro-1-benzo[b]thiophene-2-carbonyl chloride (1) was prepared from cinnamic acid in the presence of chlorobenzene and thionyl chloride. this compound (1) was treated with hydrazine hydrate to afford 3-chloro-1-benzo[b]thiophene-2-carbo ... | 2010 | 20524426 |
| purification, characterization, and crystallization of the adhesive domain of sdrd from staphylococcus aureus. | the adhesive domain of sdrd from staphylococcus aureus was solubly expressed in escherichia coli in high yield. after a series of purification steps, the purified protein was >95% pure, which was sdrd from s. aureus identified by sds-page and maldi-tof ms. crystals were grown at 18 degrees c using 25% polyethylene glycol 3350 as precipitant. diffraction by the crystal extends to 1.65a resolution, and the crystal belongs to the space group c2, with the unit cell parameters a=133.3, b=58.3, c=112. ... | 2010 | 19766722 |
| synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles. | novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1h-pyrazole-3-carboxamides (2a-e, 3, 3a-f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1h-pyrazole-3-yl)thiazoles (6a-c,7, 8, 9a-c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using ir, (1)h nmr, mass spectral data and screened for their antibacterial activity against escherichia coli (attc-25922), staphylococcus aureus (attc-25923), pseudomonas aeruginosa (attc-27853), ... | 2010 | 20053480 |
| synthesis, in-vitro antimicrobial and cytotoxic studies of novel azetidinone derivatives. | developing novel antimicrobial drugs is increasingly important in the modern pharmaceutical industry. a series of novel 3-chloro-4-[4-(2-oxo-2h-chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-ones 5a-o have been synthesized from 4-bromomethylcoumarins 1a-e and 4-aryliminomethyl-phenols 3a-c. these compounds were screened for their in-vitro antibacterial activity against two gram-positive (staphylococcus aureus and vancomycin resistant enteroccoccus) and two gram-negative (escherichia coli and shi ... | 2010 | 20205197 |
| A new triterpene from Barringtonia asiatica. | The freeze-dried bark of Barringtonia asiatica afforded a new triterpene: (3ß,11a)-11-hydroxyolean-12-en-3-yl palmitate (1). The bark also yielded mixtures of (3ß)-olean-12-en-3-yl palmitate (2a), (3ß)-urs-12-en-3-yl palmitate (2b) and (3ß)-olean-18-en-3-yl palmitate (2c) in a 2?:?1?:?4 ratio; ß-amyrin (3a), a-amyrin (3b) and germanicol (3c) in a 3?:?1?:?4 ratio; 22-O-tigloylcamelliagenin A (4a) and betulinic acid (4b) in a 2?:?1 ratio; olean-12-en-3ß,16ß,22a-triol (5), ß-sitosterol, spinasterol ... | 2011 | 21929282 |
| synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. | two series of compounds namely, dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadizines (9a-l & 11a-l) were synthesized by cyclocondensation between α-bromoindanones (7a-b) or/and α,α-dibromoindanones (8a-b) and various 3-alkyl/aryl-4-amino-5-mercapto-1,2,4-s-triazoles (3a-f) in methanol with an aim to explore their effect on in vitro growth of microorganism causing microbial infection. in vitro antibacterial activity was performed against four strains namely, staphylococcus ... | 2011 | 21899929 |